Term
| What is Zollinger-Ellison syndrome? What can it be associated with? |
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Definition
Gastrin-secreting tumor of the pancreas or duodenum
Cann be assoc. with MEN type 1 |
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|
Term
| Give 3 results of Zollinger-Ellison syndrome |
|
Definition
Stomach shows rugal thickening with acid hypersecretion
Recurrent ulcers |
|
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Term
| What are the 3 general characteristics of MEN type 1? |
|
Definition
Tumors of the:
Parathyroid
Pituitary (prolactin or GH)
Pancreatic endocrine cells
(autosomal dominant inheritance) |
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|
Term
| What's the common presentation of someone with MEN type 1? |
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Definition
| kidney stones and stomach ulcers |
|
|
Term
| 4 types of pancreatic tumors that can occur in MEN type 1 |
|
Definition
Zollinger-Ellison syndrome
Insulinomas
VIPomas
Glucagonomas (rare) |
|
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Term
| What are the 3 general characteristics of MEN type 2A? |
|
Definition
Medullary thyroid carcinoma (secretes calcitonin)
Pheochromocytoma
Parathyroid tumors
(autosomal dominant inheritance) |
|
|
Term
| What are the 3 general characteristics of MEN type 2B? |
|
Definition
Medullary thyroid carcinoma (secretes calcitonin)
Pheochromocytoma
Oral/intestinal ganglioneuromatosis (marfanoid habitus)
(autosomal dominant inheritance) |
|
|
Term
| What gene are MEN 2A and MEN 2B associated with? |
|
Definition
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