Term
|
Definition
- Sickle Cell
- Thalassemia
- G6PD
- Spherocytosis |
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Term
| Acute idiopathic thrombocytopenic purpura is MC in __ __ and is equal b/w males and females. It usually resolves within __ to __ __. Symptoms include __ __ and __ __. |
|
Definition
- younger children
- 1 to 2 months
- easy bruising and gum bleeds, nose bleeds, blood in urine |
|
|
Term
| How can you distinguish acute ITP from erythema mulitforme? |
|
Definition
- acute ITP: painless purpura
- erythema multiforme: painful purpura |
|
|
Term
| Chronic ITP occurs in __ and lasts longer than __ __. It is more common in __. It will not resolve on own and requires tmt with __. |
|
Definition
- adults
- 3 months
- women
- steroids |
|
|
Term
|
Definition
| normal except decreased platelets |
|
|
Term
|
Definition
| - Prednisone 60-100 mg/day (taper once normal platelets over 2-3 months) |
|
|
Term
|
Definition
| - IV Mehtylprednisolone 1-2g/day for 2-3 days +/- IV immunoglobulins |
|
|
Term
| Thrmobotic Thrombocytopenic Purpura classic Pentad: |
|
Definition
1. Thrombocytopenia (<20,000, +schist/helmets)
2. Microangiopathic Hemolytic Anemia (MAH)
3. Fever
4. Renal Impairment
5. Neurological Impairment |
|
|
Term
|
Definition
|
|
Term
|
Definition
- Daily plasmaphoresis to get rid of vWF and infuse cryosupernatant
- Prednisone 1-2 mg/kg/day with plasma exchange |
|
|
Term
| If you see low platelets, you also need to order __ __ to rule out DIC. |
|
Definition
|
|
Term
|
Definition
- treat underlying cause
- Fibrinogen replacement with Fresh Frozen Plasma |
|
|
Term
| Hemolytic Uremic Syndrome is mostly issue in early childhood (6 months to 4 years). What are the 4 characteristics of this condition? |
|
Definition
- Thrombocytopenia
- Microangiopathic Hemolytic Anemia (MAHA)
- Fever
- Acute Renal Failure |
|
|
Term
|
Definition
- supportive care
- maybe steroids |
|
|
Term
|
Definition
|
|
Term
| With Antiphosphholipid Antibody Syndrome the __ __ interferes with clot dissolution. |
|
Definition
|
|
Term
| LUPUS ANTICOAGULANT IS NOT LUPUS. NOT EVERYONE WITH THE ANTICOAG HAS LUPUS, BUT PPLE WITH LUPUS HAVE THE ANTICOAG. |
|
Definition
|
|
Term
| tmt for : asymptomatic pts wiht lupus anticoagulant or anticardiolipin antiboides (both go along with antiphospholipid antibody syndrome) |
|
Definition
| no tmt needed if asymptomatic |
|
|
Term
| MC defect in Northern European descent: |
|
Definition
|
|
Term
| Pts with hereditary spherocytosis have increased risk for __ __ __. |
|
Definition
|
|
Term
| Lab findings with hereditary spherocytosis: |
|
Definition
- nml-low MCV
- increased MCH
- smear= spherocytes |
|
|
Term
| Hereditary spherocytosis tmt: |
|
Definition
|
|
Term
| G6PD is a dgenetic flaw in __. These pts have a low tolerance for __ __. They should avoid __ drugs, __ beans, and ___. |
|
Definition
- NADPH
- oxidative stress
- sulfa drugs
- fava beans
- antimalarials |
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