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Embryology
James Clark
42
Medical
Graduate
09/22/2011

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Term
Gametogenesis
Definition
conversion of germ cells into male (spermatozoa) and female (oocyte) gametes
Term
Oogenesis
Definition
production of oocytes in females
Term
Spermatogenesis
Definition
production of spermatozoa in males
Term
Mitosis
Definition
cell duplication, one cell divides into two identical cells with same number of chromosomes
used for growth and repair
Term
Meiosis
Definition
reduction division
division to produce a cell (or cells) with 1/2 original number of chromosomes
females: oocyte with 23 chromosomes and 3 polar bodies
males: 4 spermatids with 23 chromosomes (2 X and 2 Y)
Term
Disjunction
Definition
chromosomes separate
Term
Spermatocyte
Definition
male gamete, primary = 46 chromosomes at start of meiosis 1, secondary = 23 chromosomes at start of meiosis 2
Term
Spermatids
Definition
product of meiosis 2 from secondary spermatocytes, 23 single chromosomes
will develop into spermatozoa
Term
Spermiogenesis
Definition
spermatids develop into sperm (inactive) that are only activated during capacitation
Term
Capacitation
Definition
maturation of sperm within the female reproductive tract (active)
gives it head and tail for motility
Term
Oocyte
Definition
female gamete, primary = 46 chromsomes at start of meiosis 1,
one secondary forms at start of meiosis 2 = 23 chromosomes
Term
Zona pellucida
Definition
membrane surrounding the secondary oocyte
must be penetrated by sperm
Term
corona radiata
Definition
cluster of cells around zona pellucida that sperm must penetrate
Term
Fertilization
Definition
sperm must penetrate corona radiata,zona pellucida, and oocyte membrane
normally in ampulla of uterine tube
oocyte finishes meiosis 2 and forms female pronucleus, zona pellucida is impenetrable, and head of sperm detaches forming male pronucleus
Term
Cleavage
Definition
series of mitotic divisions after fertilization
Term
Blastomeres
Definition
cells formed during cleavage
Term
Morula
Definition
After 16 blastomeres form, morula enters uterus on 3rd/4th day
Term
Blastocyte
Definition
Morula that has developed blastocyst cavity and inner layer(develops into embryoblast) and outer layer (develops into trophoblast)
Term
Lining of uterus
Definition
perimetrium- outer lining
myometrium- middle muscular lining
endometrium- inner lining, sheds and regenerates
Term
Compaction
Definition
result of numerous cell divisions in a closed space
Term
Implantation
Definition
blastocyst uses trophoblast to implant in uterine cavity epithelium
Term
Trophoblast
Definition
develops from outer layer of morula
pipeworks for nutrients in and waste out
2 layers:
cytotrophoblast
synctiotrophoblast
Term
Cytotrophoblast
Definition
distinct cell boundaries
undergoes mitotic division to form synctiotrophoblast
burrows, forms yolk sac
will form chorionic villi
Term
Syncytiotrophoblast
Definition
grows into endometrium to connect with endometrial blood vessels and glands
produces hCG
forms primary chorionic villi, basis of placenta
Term
hCG
Definition
human Chorionic Gonadroptropin
hormone that is detectable in mother's blood and urine by day 8 and 10, respectively
Term
Ectopic pregnancy
Definition
implantation outside uterine cavity
uterine tube, abdominal cavity, peritoneal covering, interal opening of uterus
Term
Embryoblast
Definition
inner cell mass of blastocyst
epiblast- outer layer forming the extraembryonic somatic mesoderm
hypoblast- ventral, lower layer
Term
Extraembryonic mesoderm
Definition
2 layers:
somatopleure
splanchnopleure
Term
Bilaminar Disc
Definition
2 layers:
epiblast- forms amniotic cavity
hypoblast- line cytotrophoblast and forms yolk sac
Term
Week of twos
Definition
trophoblast forms cytotrophoblast and syncytiotrophoblast
embryoblast forms epiblast and hypoblast
extraembryonic mesoderm forms somatopleure and splanchnopleure
two cavities- amniotic and yolk sac
Term
Gastrulation
Definition
development of 3 layered disk of germ layers:
ectoderm
mesoderm
endoderm
all adult cells traceable to these 3 layers
Term
Primitive streak
Definition
forms during gastrulation
composed of primitive groove, the primitive node
cephalic end of streak surrounded by primitive pit
Term
Invagination
Definition
epiblast migrates and slips under primitive streak
forms endoderm
middle cells form mesoderm
remaining cells form endoderm
Term
Notochord
Definition
forms during mesoderm formation
lies between ectoderm and endoderm
instigates organ formation, first indication of an axial skeleton
Term
Somites
Definition
loaves of bread, collections of mesoderm
little bodies on either side of developing spinal chord
Term
Lateral folding
Definition
Forms body cavities
splanchnic mesoderm form smooth and cardiac muscle cells
Term
Neurulation
Definition
beginning of nervous system (third week)
ectoderm thickens into neural plate--> neuroectoderm which folds into spinal chord
neural crest forms
Term
Organs/structures from ectoderm
Definition
maintain contact with outside world
nervous system, sensory epithelium of ear, nose, eye, skin, and hair, nails, pituitary, mammary, and sweat glands, enamel of teeth
Term
Organs/structures from mesoderm
Definition
connective tissues, tendons, cartilage, everything else
bone, muscle, urogenital, blood cells, adrenal cortex
Term
Organs/structures from endoderm
Definition
GI tract, epithelium of respiratory tract, thyroid, liver, pancreas, tonsils, thymus, urinary bladder, urethra, tympanic cavity and auditory tube
Term
Mesoderm development
Definition
complicated, know:
paraxial
intermediate- will form urogenital structures
lateral plate
Term
Placenta
Definition
2 umbilical arteries, 1 umbilical vein
placental barrier is not totally FIRM
IgM and other nutrients cross
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