Term
| Immediate transfusion rxn |
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Definition
1.MC - Febrile non-hemolytic transfusion rxn - interaction non-RBC
Si/Sx: fvr, chills, usually miltiparous, components & multiple transfusions - Not dangerous!
2.1.Acute hemolytic transfusion reaction - from RBC (ABO) indompatibility. DANGEROUS!
Si/Sx: fvr, chills, low back pain, burning site, decr tension bleed, ATN
3. Allergic Tx Rxn- plasma protein incompatibility |
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Term
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Definition
Factors VIII, IX, XI
Fact VII def
Hepatitis
Hemophilia A & B |
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Term
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Definition
Cyanosis
Chocolate blood
Asymptomatic
Fatigue, weakness, dizziness, HA
Lethargy, stupor, rep, depression |
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Term
| Clinical manifestations of sickle trait (HbAS) |
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Definition
Painless hematuria
Hyposthenuria (impaired ability to concentrate urine)
Vaso-occlusive crisis (i.e. extreme hypoxia)- rarely |
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Term
| Complications of massive PRBC's transfusions |
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Definition
Coagulopathies
Hypothermia
Microembolization -ARDS
Hypocalcemia (citrate tox)
Hyperkalemia/acidosis |
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Term
| Labs findings in vonWillebrand dz |
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Definition
| •Bleeding time, PTT •Normal: Plt, PT •Abnormal vWF or vWF Antigen or Factor VIII:C |
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Term
| WBC's & radiation (prognostic #'s) |
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Definition
| 48 hrs post exposure: >1200:very good; 300-1200 possibly lethal; <300 lethal |
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Term
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Definition
| Hemophilia B: sex-linked rec, factor XI def |
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Term
| PLT: transfusion contraindicated in? |
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Definition
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Term
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Definition
| ❑ 1st line tx: plasmapharesis (fresh frozen plasma exchange) ❑ Rx: Corticosteroids, plasmapharesis w/FFP, ASA, splenectomy, heparin, vancristine, gamaglobulin ❑88% mortality in 3mo if unTx; 17% w/Tx |
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Term
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Definition
| •Heparin or Coumadin o/d •Vit K def. & mod-severe liver dz •DIC •Dysfxn/def in fibrinogen •Massive transfusion of stored blood (def factors V & VIII) |
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Term
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Definition
| Vaso-occlusive, hemolytic (ill, jaundice) •Sequestration (kids 6 mo-6 y/o, abd pain, pallor, shock) •Aplastic crisis (usually 2ry to parvovirus) |
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