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Voltage Potentials that are read by AERs come from... |
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Transmembrane ionic current flow |
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3 ways we look at transmembrane ionic current flow |
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1. Rest state - negative 2. Excited state - positive 3. Return to rest state - negative |
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Distribution of current flow in extracellular space. This creates an action potential (positive activity) |
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Transmembrane current flow |
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action potential- travels along the axon of the neuron |
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current flow between two or more neurons |
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negative polarity at one end and positive polarity at the other end. The positve end forms the transmission. This is how current travels |
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factors effecting surface recorded AERs |
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Location of recording electrodes in relation to electrical field/dipole i.e. Near field response v. far field response |
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invasive 1. intracraniel (pretty close to the potential field) 2. intraoperative monitoring (electrode directly on area that you are monitoring) 3. transtympanic membrane EcochG (needle thru TM ends near prominatory to measure at the cochlea) |
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non-invasive scalp recorded AER - reduces amplitude and special resolution (combo of several differfent waves) |
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Open potential fields vs. Closed potential fields |
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Open- where axons are parallel, enhance volume conduction Closed- where axons are orientated in different directions, may cancel electrical fields (++ or --) |
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Volume conduction increases for... |
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neurons with a wider area of neuron and extended duration voltage changes (longer transient voltage potential) |
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How many types of neuron make up the VIII craniel nerve and auditory brainstem response? |
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5 Each have its own characteristics, but not sure which are evoked in AER. |
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Evoked responses are a product of _____ transmembrane electrical activity for thousands of CNS neurons |
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Greater number of neurons = |
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= larger amplitude of AER |
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Afferent Auditory System = |
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Efferent Auditory System = |
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Electrocochleography (EcochG) - generated by? gives info. about? |
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- generated by Compound VIII Craniel nerve AP - gives info about OHC and really where evoked responses are generated |
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3 cochlear potentials evoked by sound: |
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1. Cochlear microphonics (CM) 2. Summating potential (SP) and Action Potential (AP) |
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Cochlear microphonics comes from... |
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- an alternating current (AC) potential that mimics the waveform of the stimulus (i.e. pure tone stimulus produces a sine wave of the same frequency) - CM has no latency (begins with the stimulus) - Arises from the OHCs and reflects activity from the basal portion of the basilar membrane |
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Where is CM measured from invasivley and noninvasivley? How is it best elicited by? What happens when there are alternating stimulus polarity? |
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1. promontory of the middle ear (invasive) 2. The external ear (tiptrode) (non-invasive) 3. it cancels the CM out! So you must use a single polairty. |
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movement in positve direction (positive polarity) |
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Pressure wave in a negative direction (negative polarity) f.y.i. alternating polarity switches between condensation and rarefaction polarities. |
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Summating Potential (SP) is a direct current potential. How is it recorded? Origin? Most prominent? |
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1. from a continuous tone or transient acoustic stimulus (click or tone burst) 2. unknown, but may be linked to innr and outer hair cell activity 3. prominent with high frequency tone burst stimuli |
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Action Potential (AP) aka? represents the compound AP (synchronous firings of many fibers) of the...____ due to_____ Largest for what type of stimuli? |
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- also referred to as N1 (i.e. wave 1 for ABR) ...VIII nerve due to...activity in the basal portion (first turn/high frequency portion of cochlea) - transient stimuli with increased intensity |
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What happens when you increase the intensity (for an ABR)?? |
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- the latency is decreased. i.e. you will see your wave earlier. High intensity stimuli produces mostly basal cochlear activity |
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N2 derives from... what happens when you increase amplitude? |
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- VIII nerve firing from the apical (second turn/lower frequency) regions of the cochlea. - equivalent to Wave II of ABR when click is presented at high intensity - amplitude increases with decreased intensity |
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distal portion of the VIII nerve (afferent activity of the VIII neve fibers as they leave the cochlea and enter the iternal auditory canal) |
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- proximal portion of the VIII nerve as it enters the brainstem (first order neurons) f.y.i. -non consistently rcorded in small children due to shorter VIII nerve length -reflects activity of the VIII nerve itself, not BS -reliable wave II can still be recorded in brain dead, this supports VIII nerve origin |
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- second order neuron, beyone the VIII nerve - possibly in or near the cochlear nucleus - negative trough generated from the trapezoid body |
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Wave IV - leading shoulder to wave V - comes from... |
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third order neurons located in the Superior Olivary Complex with help from the CN and LL. - referred to as Wave IV-V complex |
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- generated from end o the LL fibers entering the inferior colliculus (contra to stimulated ear) |
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Waves VI and VIII come from... |
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