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Eicosanoids
Eicosanoids
13
Pharmacology
Professional
09/05/2011

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Cards

Term
Montelukast
Definition
-LT receptor antagonist
-asthma, seasonal allergies
-prevents normal LT bronchoconstriction and vasoconstriction
Term
Zafirlukast
Definition
-LT receptor antagonist
-asthma, oral
-prevents normal LT bronchoconstriction and vasoconstriction
Term
Zileuton
Definition
-5-LOX inhibitor -asthma, oral -needs to be taken prophylactically (before asthma attack)
Term
Epoprostenol
Definition
-PGI2 (prostacyclin) -IV -vasodilation to relieve pulmonary HTN
Term
Treprostinol
Definition
-PGI2 analog
-vasodilated to relieve pulmonary hypertension
-primary pulmonary hypertension
Term
Iloprost
Definition
-PGI2 analog
-Pulmonary arterial hypertension; inhalation
-primary pulmonary hypertension
Term
Dinoprostone
Definition
-Synthetic PGE2 preparation, administered vaginally for oxytocic use
-labor induction; vaginal suppositories, gel
-inducing abortion in second trimester
- for missed abortion
- for benign hydatidiform mole
- cervix ripening for labor induction (gel) in patients at or near term
-SE for PGE2 are moderate: including nausea, vomiting and diarrhea
Term
Misoprostol
Definition
-an oral oxytocic synthetic analog of PGE1
-stomach ulcers, labor induction; Oral
-used to prevent ulcers
- used to produce early abortion
- toxicities include: cramping pain and diarrhea
Term
Carboprost
Definition
-PGF2a analog
-labor induction, abortifacient in early pregnancy; IV
-used to induce second- trimester abortions and to control postpartum hemorrhage not responding to conventional methods of management
-SE include vomiting and diarrhea (from GI smooth muscle stimulation), bronchoconstriction may also occur
Term
Alprostadil
Definition
-PGE1
-erectile dysfunction; penile injection
-SE. Penile pain is a common occurrence, probably related to PGE algesic effects.
-prolonged erection and priapism occur in less than 4% of patients
Term
Latanoprost
Definition
-PGF2a analog
*glaucoma, ocular hypertension; ophthalmic solution
-Administered as drops into the conjunctival sac once or twice daily
-SE: irreversibly brown pigmentation of the iris and eyelashes, drying of the eyes and conjunctivitis
Term
Bimatoprost
Definition
-PGF2a analog
*glaucoma, ocular hypertension; ophthalmic drops
Term
Travoprost
Definition
-PGF2a analog
-glaucoma, ocular hypertension; ophthalmic solution
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