Term
| Issues with drug-receptor interaction for older adults in regards to metabolism of drugs: |
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Definition
| The brain receptors become more sensitive. |
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Term
| Nursing considerations about more sensitive brain receptors? |
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Definition
| Psychoactive drugs become very potent. |
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Term
| Metabolism issues related to the physical condition of the liver: |
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Definition
| The liver mass shrinks, hepatic blood flow reduced. |
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Term
| Enzyme issues related to the livers decreased function: |
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Definition
| Enzymes lose the ability to process some drugs, prolonging the half life |
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Term
| Rate of metabolism in older adults compared to younger adults. |
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Definition
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Term
| Absorption issues in older adults for metabolism of medications: |
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Definition
| Gastric emptying rate and GI motility is slowed. |
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Term
| Cellular issues in older adults in relation to absorption: |
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Definition
| Absorptive capacity and active transport mechanisms decline. |
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Term
| Circulation issues in older adults for medication metabolism: |
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Definition
| Vascular nerve control is less stable |
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Term
| What does Vascular Nerve Control less stable mean? |
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Definition
| Drug responses may have more than the expected response. Digoxin can slow the heart rate more than expected, antihypertensives may drop blood pressure too low. |
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Term
| What are excretion issues for older adults through the kidneys? |
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Definition
| Renal flow rate, glomerular filtratrion rate, renal tubular secretion & reabsorption and nephrons decline. |
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Term
| What are the primary concerns for the new issues in kidney and GI motility? |
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Definition
| The half life for drugs is lengthened, blood and waste is removed much more slowly, drugs stay in the body longer, increasing toxicity. |
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Term
| What are the distribution effects from aging in regards to metabolism of drugs in older adults? |
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Definition
| Lower lean body mass and increased adipose, lower total body water. |
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Term
| How do the body mass changes effect the distribution of medications? |
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Definition
| Water soluble medications have less water available. Plasma protein decreases. Drugs have less to bind to and "free" drug levels rise. |
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