Term
|
Definition
phosphodiesterase 5 inhibitors (PDE5 I)
prostaglandin E-1
pellets |
|
|
Term
| phosphodiesterase 5 inhibitors (PDE 5 I) |
|
Definition
sildenafil
verdenafil
tadalafil |
|
|
Term
|
Definition
| 1 hr before sexual activity |
|
|
Term
|
Definition
taken 1 hr before sexual activity
decr. dose in >65 yrs |
|
|
Term
|
Definition
selectively inhibit PDE-5 -> incr cGMP levels
=makes erection last longer
***enhance normal response to sexual stimuli! |
|
|
Term
which PDE-5 I absorption
is NOT affected by food |
|
Definition
|
|
Term
| absorption of sildenafil and vardenafil is slowed by? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
HA
flushing
dyspepsia
nasal cong
hypoTN
priapism
color vision changes (NAION) |
|
|
Term
| how does vardenafil change EKG |
|
Definition
|
|
Term
| PDE-5 I cannot be used w/ what drugs |
|
Definition
nitrates->causes severe hypoTN
alpha blockers->postural hypoTN
|
|
|
Term
| how does PDE-5 I affect P3A4? |
|
Definition
| in inhibits the enzyme->suppress met. and incr levels |
|
|
Term
|
Definition
|
|
Term
|
Definition
injection
produces erection when injected directly into corpus cavernosum
relaxation of sm mm |
|
|
Term
| what is the max that alprostadil can be dosed |
|
Definition
| NOT to be used more than 3x/wk and more than 1x/24hrs |
|
|
Term
| how should the dose of alprostadil be determined? |
|
Definition
|
|
Term
|
Definition
burning
prolonged erection
penile fibrosis w/ contd used |
|
|
Term
|
Definition
| loaded into plastic applicator and inserted 1.5" into the urethra |
|
|
Term
| how quickly do pellets take effect |
|
Definition
5-10 mins (determined in office)
lasts 30-60 mins
NO MORE THAAN 2x/24 hrs |
|
|
Term
|
Definition
|
|
Term
|
Definition
5-alpha reductase inhibitors
alpha-1 adrenergic antagonists
saw palmetto |
|
|
Term
| 5-alpha reductase inhibitors |
|
Definition
|
|
Term
|
Definition
inhibit 5-alpha reductase
-> converts test to DHT (the active form in prostate) |
|
|
Term
| finasteride decr. DHT by _____% w/o reducing ______ |
|
Definition
|
|
Term
| finasteride is good at treating what type of obstruction? |
|
Definition
|
|
Term
| finasteride is most effective in what type of patients |
|
Definition
| pts w/ HIGH degree of enlargement |
|
|
Term
| do BPH pts on finasteride require lifelong or acute tx? |
|
Definition
|
|
Term
| how long does it take finasteride to take effect |
|
Definition
|
|
Term
|
Definition
decr. ejaculate vol. and libido
decr serum PSA
|
|
|
Term
| what test should be done when Rx finasteride |
|
Definition
PSA before Rx, and rechecked in 6mos
if no fall -> think CA |
|
|
Term
|
Definition
inhibit 5-alpha reductase
-> STOPS testosterone ->DHT |
|
|
Term
| where does dutasteride work |
|
Definition
| prostate, skin, and liver! |
|
|
Term
| which has a more complete reduction in DHT finasteride or dutasteride? |
|
Definition
|
|
Term
|
Definition
decr urinary s/sx
delay progression |
|
|
Term
|
Definition
harmful to male fetus
-> inhibit external male genitalia
(women DO NOT handle) |
|
|
Term
| CI/interactions dutasteride |
|
Definition
NO PREGO
cannot donate blood (during and 6 mos later) |
|
|
Term
| alpha-1 adrenergic antagonists |
|
Definition
terazosin
doxazosin
tamsulosin
alfuzosin |
|
|
Term
| MOA alpha-1 adrenergic antagonists |
|
Definition
| relax sm mm in bladder neck, prostate, urethra |
|
|
Term
| alpha 1 adrenergic antagonists work best on what type of obstruction |
|
Definition
| dynamic (expulsion) of the urethra |
|
|
Term
| which alpha 1 adr. ant. work on blood vessels |
|
Definition
|
|
Term
| which alpha 1 adr. ant. work best on prostate |
|
Definition
|
|
Term
| alpha 1 adrn. ant are preferred in what type of pts |
|
Definition
|
|
Term
|
Definition
terazosin, doxazosin -> decr BP
tamsulosin-> abn ejaculation |
|
|
