Term
Shigellosis (Bacterial Dysentery) dysentery: |
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Definition
waves of intense cramps passage of frequent small-volume,
bloody, mucoid stools |
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Shigella species small gram –ve rods found primarily in primates |
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fecally contaminated food, water person-to person |
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2-3 days acid-resistant (as few as 10 CFU can cause disease) |
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mild diarrhea to fatal dysentery microbes penetrate intestine produce enterotoxins → water released from intestinal lining infection in small intestine → watery diarrhea infection in large intestine → dysentery usually lasts 1 week if no complications hemolytic uremic syndrome (HUS) Shigella dysenteriae produces Shiga toxin microvasculature damage and hemolytic anemia renal failure |
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antibiotics can be used; many strains resistant (R factors) excessive fluid loss requires electrolyte therapy, salt tablets or IV,
(most often in children and elderly) recovered are carriers for ~ 1 month |
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