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Dr. V
Pharmacology Exam 3
28
Pharmacology
Professional
04/01/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
monoclonal antibodies
Definition
bind and kill tumor cells; binds to specific antigen on tumor cell, kills tumor by fixing complement, but ADCC, osonize, deliver cytotoxic or radioisotope drug to tumor
Term
Anti-CD20, Anti-Her2, Denileukin diftitox, Bretuximab vendotin, Trastuzumab (Herceptin)
Definition
monoclonal antibodies
Term
Anti-CD20 mAb
Definition
B cell specific; used for non-Hodgkin's lymphoma, other leukemias expressing antigen, malignant B cells
Term
Rituximab (Rituxan)
Definition
Anti-CD20 mAb
Term
Anti-Her2 mAb
Definition
Growth factor receptor, a member of epidermal growth factor receptor family, expressed at high levels on some breast cancers, Her2 is also overexpressed on Gastric cancer
Term
Trastuzumab (Herceptin)
Definition
Anti-Her2 mAb; drives apoptosis when binding to cancer cells and activating ADCC
Term
Bretuximab vendotin (Adcetris)
Definition
another andtibody conjugate, binding CD30 a protein found on surface of some lymphocytes, including a number of lymphomas. mAb is conjugated to a cytotoxic drug (auristatin).
Term
Denileukin diftitox (Ontak)
Definition
recombinant IL2 conjugated to diphtheria toxin. IL2 binds to CD25 = the high affinity proportion of the IL 2 receptor expressed on activated T cells; Diphtheria toxin kills the target cell; Used for leukemias and lymphomas where cancerous white blood cell expresses CD25
Term
Ipilimumab (yervoy); cellular immunotherapy and immunostimulants
Definition
Promote T cell activation by blocking CTLA4; used for malignant melanoma
Term
cellular immunotherapy and immunostimulants
Definition
Ipilimumab (yervoy), Sipuleucel-T (Provenge)
Term
Sipuleucel-T (Provenge)
Definition
cancer vaccine; autologous cellular immunotherapy in which activates T cells with TCR specific for prostate cancer antigen (PAP); used for prostate cancer
Term
PAP
Definition
prostatic acid phosphatase that is present on many cancer prostatic cells
Term
Cytokines
Definition
IL-2 (Aldesleukin), IFN alpha
Term
IL-2 (Aldesleukin)
Definition
severe side effects, shock and death
Term
IFN alpha
Definition
MOA not fully known but activates T cells which act on tumor cells to slow proliferation
Term
Tyrosine kinase inhibitors
Definition
Imatinib (Gleevec), ii. Erlotinib (Tarceva), Cetuximab (Erbitux) anti-EGFR
Term
Tyrosine kinase
Definition
enzymes that phos proteins (ATP), and others initiates signaling cascades that regulate many cellular functions; prolif, survival, motility, differentiation, angiogenisis
Term
tyrosine kinase receptors
Definition
VEGFR (vascular endothelial), EGFR (epidermal), PDGRFR (platelet derived, ERB (Her-2 human epidermal GFR), FGFR (fibroblast)
Term
Tyrosine kinase non-receptor
Definition
ABL
Term
Imatinib (Gleevec)
Definition
Used for chronic myelogenous leukemia (CML) and other leukemias that are BCL-ABL+ or Ph+; selective for BCL-ABL and prevents ATP from binding
Term
Erlotinib (Tarceva)
Definition
binds/ blocks intracellular site on Epidermal GFR, blocking proliferation, inhibits angiogenesis
Term
Bevacizumab (Avastin)
Definition
Term
Cetuximab (Erbitux) anti-EGFR
Definition
Term
Proteosome inhibitors
Definition
Bortezomib (Velcade) and Carfilzomib (kyprolis)
Term
proteosome
Definition
barrel-shaped enzyme complex to degrade proteins; clearance of obsolete, damaged/ abnormal proteins, responsible for antigen presentation, regulates proteins that affect cell cycle apoptosis
Term
NFKB, Caspases, Bcl, cyclins
Definition
proteosomes
Term
Bortezomib (Velcade) and Carfilzomib (kyprolis)
Definition
used for multiple myeloma; constipate plasma cell myeloma, abnormal proteins build up in the cell that can't be cleared/ recycled and this in turn signals cell to die; block activation of NFKB by preventing degradation of the inhibitor protein attached to NFKB
Term
NFKB
Definition
trascription factor, and when activated it promotes IL-6 which drive cell prolif and activates cell adhesion molecules which sticks tumor cells to the bone marrow cells and promotes GEF release stimulating angiogenesis
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