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Drugs
Drugs and their effects.
26
Psychology
Undergraduate 2
11/13/2012

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Term
PCP (angel dust)
Definition
Glutamate NMDA receptor antagonist.
Causes hallucinations.
Term
Benzodiazepines
Definition
Binds to GABA allosteric site.
Muscle relaxent, impairs memory and learning.
Used to treat anxiety, among most commonly prescribed drugs.
Term
Barbiturates
Definition
Binds to GABA allosteric site.
Calming, once used as anaesthetic but caused respiratory blocks therefore no longer used.
Interferes with memory and learning.
Term
Steroids
Definition
Binds to GABA allosteric site.
Reason why mood and anxiety can fluctuate.
E.g. low progesterone levels lead to heightened anxiety or "PMS"
Term
Picrotoxin
Definition
Binds to GABA allosteric site.
GABA(a) receptor inhibitor.
Causes convulsions.
Term
Alcohol
Definition
Binds to GABA allosteric site for barbiturates or benzodiazepines.
Regulates GABA(a) receptor.
Term
Amphetamines
Definition
Dopamine agonist.
Used for disorders of excessive sleep.
Term
Anti-schizophrenic Drugs (antipsychotic drugs)
Definition
Dopamine receptor D2 antagonist.
Among most commonly prescribed drugs, reduces symptoms of schizophrenia.
Can cause motor side effects
Term
Atomoxetine
Definition
Norepinephrine receptor agonist (re-uptake inhibitor).
Used in treatment for ADHD.
Term
Monoamine Oxidase Inhibitor
Definition
Agonist, anti-depressant.
Formerly used to treat depression but caused cardiac arrests therefore now only used in small, controlled, dosages.
Term
Beta Blockers
Definition
Epinephrine antagonist.
Used to treat anxiety but only periphery aspects of anxiety (accelerated heart beat).
Also used to help regulate heart beat of those who have irregular heart beats.
Term
Cocaine
Definition
Catecholamine (dopamine, norepinephrine and epinephrine) agonist (blocks re-uptake).
Used to reduce pain.
Effects on dopamine cause addiction (reward system).
Effects on norepinephine cause the high.
Term
Fluoxetine
Definition
Serotonin re-uptake inhibitor.
Component of Prozac.
Used to treat depression and OCD.
Term
Fenfluramine
Definition
Serotonin re-uptake inhibitor and stimulates release.
Once used to treat obesity but caused heart conditions (appetite suppressant).
Term
Lorcaserin
Definition
Satiety enhancer (makes you feel full sooner).
FDA approved in June 2012.
Term
Botullinum Toxin
Definition
A.k.a. Botox
ACh antagonist for nicotinic receptor (ionotropic), irreversible.
Anaerobic bacterium found in improperly canned foods (dies with heat, a.k.a. cooking food).
Causes paralysis.
Used to treat blepharospasm (the inability to keep eyes open, paralyze muscles we do not want to over contract), also used for migraines and wrinkles.
Term
Black Widow Spider Venom
Definition
Stimulates release of ACh.
Opposite effects of Botox and much less toxic.
Can cause convulsions.
Term
Atropine and Scopolamine
Definition
Competitive muscarinic receptor antagonist.
Extract of belladonna plant, dilates pupils and makes women look more attractive.
Effects in object recognition - does not effect memory retrieval rather the formation of new memories.
Term
Curare
Definition
Nicotinic receptor antagonist.
Once used as coating on arrowheads.
Causes paralysis and then death.
Term
Smoking
Definition
Agonist on nicotinic receptor.
Makes you feel more alert and enhance working memory.
ADHD and schizophrenics smoke more than average population (attempt to self-medicate).
Term
Opiate Drugs
Definition
Exogenous ligand of opioids.
Used as pain killer medication.
Term
Morphine
Definition
Opioid agonist.
Pain relief.
Term
Naloxone
Definition
Opioid antagonist.
First line of treatment when someone overdoses on opiate drugs.
Term
Cannabinoids
Definition
Inhibit pre-synaptic neuron.
Reduce pain, memory.
Increase sleep, feeding.
Term
Adenosine
Definition
Inhibitory neurotransmitter.
Caffeine counteracts effects.
Term
Steroid Hormones
Definition
Synthesized on gonads and released immediately after.
Effect sex-related and stress related functions / responses.
Act through nuclear receptors (longer lasting) or membrane receptors (immediate / fast effects).
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