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Drugs
Drugs
34
Medical
Graduate
08/29/2012

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Cards

Term
Bethanechol
Definition
Cholimmetic. Activates Bowel and Bladder smooth
muscle; resistant to AChE. Bethany call me if you want to activate your Bowels and Bladder (postoperative)
Term
Carbechol
Definition
Cholimmetic. CARBon copy of acetylcholine.
Term
Pilocarpine
Definition
Cholimmetic. Activates sweat, tears, and saliva. Contracts ciliary muscle of eye (open angle),
pupillary sphincter (narrow angle); resistant
to AChE. You cry, drool, and sweat on your
PILOw.
Term
Methacholine
Definition
Cholimmetic. For testing for asthma.
Term
Neostigmine
Definition
Anticholinesterase (indirect agonist). Postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative). NO CNS penetration.
Term
Pyridostigmine
Definition
Anticholinesterase (indirect agonist). Increase endogenous ACh; Increase strength. PyRIDostigmine gets RID ofmyasthenia gravis.
Term
Edrophonium
Definition
Anticholinesterase (indirect agonist). Short lasting.
Term
Phyostigmine
Definition
Anticholinesterase (indirect agonist). Increase endogenous ACh. PHYsostigmine PHYxes
atropine overdose. Also glaucoma.
Term
Echothiophate
Definition
Anticholinesterase (indirect agonist). Glaucoma.
Term
Donepezil
Definition
Anticholinesterase (indirect agonist). Alzeihmers.
Term
Cholinesterase Inhibitor Poisoning Sx
Definition
Causes Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation ofskeletal muscle and CNS, Lacrimation, Sweating, and Salivation.

Organophosphates cause this (insecticides from farmers)
Term
Muscarinic Antagonists - list effects and drugs.
Eye
Definition
Produce Mydriases
Atropine, homatropine, tropicamide
Term
Benzotropine
Definition
PARKinson's disease- PARK my BENZ. Muscarinic antagonist.
Term
Scopolamine
Definition
Muscarinic Antagonist - motion sickness.
Term
Ipratropium
Definition
Muscarinic antagonist. Asthma, COPD (I pray I can breathe soon!)
Term
Methscopolamine, pirenzepine, propantheline
Definition
Muscarinic atagonist (GI)
Term
Oxybutynin, glycopyrrolate
Definition
Muscarinic antagonist - GU
Term
Atropine Actions
Definition
Blocks DUMBBELSS
Term
Atropine toxicity
Definition
Inc body temperature (due to J, sweating); rapid pulse; dry mouth; dry, flushed skin; cycloplegia; constipation; disorientation.
Can cause acute angle-closure glaucoma in elderly, urinary retention in men with prostatic hyperplasia, and hyperthermia in infants.
Blocks DUMBBELSS (see previous page)
Side effects:
Hot as a hare Dry as a bone Red as a beet Blind as a bat Mad as a hatter
Term
Epinephrine
Definition
Sympathomimetic. Anaphylaxis, glaucoma (open angle), asthma, hypotension

a1,a2,b1,b2
Term
Norepinephrine
Definition
Sympathomimetic. a1,a2. Hypotension (but J, renal perfusion)
Term
Isoproterenol
Definition
Sympathomimetic. b1, b2. AV block (rare)
Term
Dopamine
Definition
Sympathomimetic. D1, a1,a2,b1,b2. Shock. inotropic and chronotropic;
Term
Dobutamine
Definition
Sympathomimetic. a1,a2,b1,b2. Heart failure, cardiac stress testing; inotropic,
but not chronotropic
Term
Phenylepherine
Definition
Sympathomimetic. a1,a2. Pupillary dilation, vasoconstriction, nasal
decongestion
Term
Metaproterenol, albuterol, salmeterol,
terbutaline
Definition
Sympathomimetics. b1, b2 MAST: Metaproterenol and Albuterol for
acute asthma; Salmeterol for long-term treatment; Terbutaline to reduce premature uterine contractions
Term
Ritodine
Definition
Sympathomimetic. beta2. Reduces premature uterine contractions
Term
Indirect Sympathomimetics
Definition
Amphetamine, Ephedrine, Cocaine.
Term
Phenoxybenzamine (irreversible)
Definition
Pheochromocytoma (use phenoxybenzamine
before removing tumor, since high levels of released catecholamines will not be able to overcome blockage)

Toxicity: Orthostatic hypertension, reflex taychachardia.
Term
Phentolamine
Definition
Non-selective alpha blocker. Give to patients on MAO inhibitors who eat
tyramine-containing foods
Term
Prazosin, terazosin, doxazosin.
Definition
alpha1 blockers. Hypertension, urinary retention in BPH
Term
Mirtazapine
Definition
Alpha2 selective. Depression
Term
Acebutolol, betaxolol, esmolol, atenolol, metoprolol, propranolol, timolol, pindolol, labetalol.
Definition
Beta blockers.
Term
Toxicity of beta blockers
Definition
Impotence, exacerbation of asthma,
cardiovascular adverse effects (bradycardia, AV block, CHF), CNS adverse effects (sedation, sleep alterations); use with caution in diabetics
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