Term
| Name 5 HMG-CoA Reductase Inhibitors (Statins) |
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Definition
-Atorvastatin
-Fluvastatin
-Lovastatin
-Pravastatin
-Simvastatin |
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Term
| What is the mechanism of action of the Statins? |
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Definition
| They inhibit the HMG-CoA reductase enzyme in the liver, leading to a decrease in serum cholesterol and LDL concentration. |
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Term
| What is a contraindication of the Statins? |
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Definition
|
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Term
|
Definition
-Headache
-Myalgia (muscle pain)
-Liver damage
-GI irritation |
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Term
| What are the nursing considerations when administering Statins? |
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Definition
-Give in the evening to coincide with body's timing of cholesterol production
-Perform liver function test
-Follow-up at regular intervals |
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Term
|
Definition
-Cholestyramine resin
-Colestipol |
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Term
| What is the mechanism of action of the Bile Acid Resins? |
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Definition
| They bind with bile acids in the Gi tract. |
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Term
| What are 2 contraindications of the Bile Acid Resins? |
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Definition
-Pediatrics
-Biliary obstruction |
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Term
| ADRs of Bile Acid Resins (2) |
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Definition
-Steatorrhea (excess fat in feces)
-Fat-soluble vitamin deficiencies |
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Term
| What are the nursing considerations when administering Bile Acid Resins? |
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Definition
| Mix with full glass of water and do not administer with other medications. |
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Term
| What are cardiovascular diseases and how are they caused? |
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Definition
| Usually refers to atherosclerosis. It is caused by a build up of fatty materials such as cholesterol in the artery wall. |
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Term
| Name 2 Fibric Acid Derivatives. |
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Definition
|
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Term
| What is the mechanism of action of Fibric Acid Derivatives? |
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Definition
| They suppress VLDL and chlyomicron synthesis resulting in a reduction of triglyceride levels. |
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Term
| What are the contraindications of Fibric Acid Derivatives (2)? |
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Definition
-Gallbladder disease
-Liver or biliary cirrhosis |
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Term
| Name 1 Nicotinic Acid Derivative. |
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Definition
|
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Term
| What is the mechanism of action of Niacin? |
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Definition
| The mechanism of action of niacin is unclear. |
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Term
| What are the contraindications of Niacin (2)? |
|
Definition
-Liver disease
-Severe hypotension |
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Term
|
Definition
-Flushing
-Itching
-Orthostatic hypotension
-GI irritation |
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Term
| What are the nursing considerations when administering Niacin? |
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Definition
| Alcohol should be avoided as it increases flushing. |
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Term
| Name 1 Cholesterol Absorption Inhibitor. |
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Definition
|
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Term
| What is the mechanism of action of Ezetimibe? |
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Definition
| It decrease the amount of cholesterol absorbed in the GI tract. |
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Term
|
Definition
-Diarrhea
-Arthralgia (joint pain) |
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Term
| What are the nursing considerations when administering Ezetimibe? |
|
Definition
| Monitor coagulation studies if patient is also receiving warfin. |
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Term
| Name 1 Lipid-Regulating Agent. |
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Definition
|
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Term
| What is the mechanism of action of omega-3-triglycerides? |
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Definition
| They disrupt triglyceride synthesis. |
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Term
| Contraindications of Omega-3-Triglycerides (1) |
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Definition
|
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Term
| ADRs of Omega-3-Triglycerides (2) |
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Definition
|
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Term
| What are the nursing considerations when administering Omega-3-Triglycerides? |
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Definition
| They may potentiate anticoagulants. Monitor coagulation studies. |
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