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Details

Drugs of ANS
Drugs that affect the Autonomic Nervous System
109
Pharmacology
Professional
10/22/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

Demser

Definition
  • Methytyrosine
  • α-Methytyrosine
  • Adrenergic
  • Interfere with the synthesis of neurotransmitter

 

Term

Aldomet

Definition
  • α-Methyldopa (false transmitter)
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
    • α2
  • Use to treat hypertension
  • Interfere with the synthesis of neurotransmitter
  • Competitive substrate with formation of active compound (NE)

 

Term

Serpasil

Definition
  • Reserpine
  • Adrenergic
  • Blockade of transport processes by inhibiting VMAT-2 (storage vesicles)

 

Term

Cocaine

Definition
  • Adrenergic receptor agonist
  • Indirect-acting agent
  • Local anesthetic
  • Blockade of transport processes by inhibiting NET

 

Term

Antidepressants

Definition
  • Adrenergic
  • Blockade of transport processes by inhibiting NET

 

Term

Cholinergic

Definition

There is no cholinergic drug that:

 

  • Interfere with the synthesis of the neurotransmitter
  • Are competitive substrates with the formation of active compound
  • Promote the release of the neurotransmitter
  • Interfere with the release of the neurotransmitter

 

Term

Ismelin

Definition
  • Guanethidine
  • Adrenergic
  • Promotes the release of the neurotransmitter by displacing the transmitter from from the storage vesicles
  • Interfere with the release of the NT by blocking its release from the nerve terminal

 

Term

Hylorel

Definition
  • Guandadrel
  • Adrenergic
  • Promotes the release of the neurotransmitter by displacing the transmitter from the storage vesicles
  • Interfere with the release of the NT by blocking its release from the nerve terminal

 

Term

Tyramine

Definition
  • Not used clinically
  • Research-no clinical indication
  • Adrenergic receptor agonist
  • Indirect-acting agent
  • Promotes the release of neurotransmitter by displacement from cytoplasmic pool

 

Term

Amphetamine

Definition
  • Adrenergic receptor agonist
  • Indirect-acting agent
  • Adderall-ADHD
  • Promotes the release of neurotransmitter by displacement from cytoplasmic pool

 

 

Term

Ephedrine

Definition
  • Adrenergic receptor agonist
  • Mixed-acting agent
    • α1
    • α2
    • β1
    • β2 plus indirect
  • Promotes the release of neurotransmitter by displacement from cytoplasmic pool

 

Term

Tensilon

Definition
  • Edrophonium
  • Cholinergic
  • Interfere with the metabolism of the NT
  • Acetylcholinesterase inhibitor
  • Reversible, Competitive Inhibitor
  • Used as a diagnostic agent in myasthenia gravis
  • Does cross the BBB and weak affinity for the receptor (rapid onset & short duration)

 

Term

Cognex

Definition
  • Tacrine
  • Cholinergic
  • Interfere with the metabolism of the NT
  • Acetyl-cholinesterase inhibitor
  • Reversible, Competitive Inhibitor
  • First drug market for the treatment of Alzheimer's 
  • Worked in the CNS and periphery (side effects)
  • Not very good and caused liver damage

 

Term

Aricept

Definition
  • Donepezil
  • Cholinergic
  • Interfere with the metabolism of the NT
  • Acetylcholinesterase inhibitor
  • Reversible, Competitive Inhibitor
  • Used in the treatment of Alzheimer's disease
Term

Physostigmine

Definition
  • Eserine
  • Antilirium
  • Cholinergic
  • Interfere with the metabolism of the NT
  • Acetylcholinesterase inhibitor
  • Substrate inhibitors
  • Treatment of glaucoma (no longer used)

 

Term

Pyridostigmine

Definition
  • Mestinon
  • Regonol
  • Cholinergic
  • Interfere with the metabolism of Ach
  • Acetylcholinesterase inhibitor
  • Substrate inhibitor
  • Used in the treatment of Myasthenia gravia

 

Term

Exelon

Definition
  • Rivastigmine
  • Cholinergic
  • Interfere with the metabolism of Ach
  • Acetylcholinesterase inhibitor
  • Substrate inhibitor
  • Used in the treatment of Alzheimer's disease

 

Term

Galantamine

Definition

 

  • Razadyne
  • Reminyl
  • Cholinergic
  • Interfere with the metabolism of Ach
  • Acetylcholinesterase inhibitor
  • Substrate inhibitor
  • Used in the treatment of Alzheimer's disease

 

Term

Adrenergic

Definition
  • No drugs listed that interfere with the metabolism of NE by preventing re-uptake of NE into sympathetic nerve ending

 

Term

Catapres

Definition
  • Clonidine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
    • α2
  • Use to treat hypertension
  • Interfere with the release of the NT
  • Stimulation of presynaptic receptors (α2A and α2C)
Term

Parnate

Definition
  • Trancylpromine
  • Adrenergic
  • Interfere with the metabolism of NT by inhibiting MAO
  • Nonselective inhibition (MAO-A and MAO-B)

 

Term

Nardil

Definition
  • Phenelzine
  • Adrenergic
  • Interfere with the metabolism of NT by inhibiting MAO
  • Nonselective inhibition (MAO-A and MAO-B)

 

Term

Selegiline

Definition
  • Eldepryl
  • EMSAM
  • Adrenergic
  • Interfere with the metabolism of NT by inhibiting MAO
  • Selective inhibition of MAO-B

 

Term

Miochol-E

Definition
  • Acetylcholine
  • Muscarinic receptor agonist 
  • Miscellaneous indications
  • Used during surgery
  • Causes lacrimation and miosis (rapid results)

 

Term

Urecholine

Definition
  • Bethanechol
  • Muscarinic receptor agonist
  • Miscellaneous indications
  • Used to stimulate the GI tract and urinary tract when atony occurs post-op

 

Term

Salagen

Definition
  • Pilocarpine (oral)
  • Muscarinic Receptor agonist
  • Miscellaneous indications

 

Term

Evoxac

Definition
  • Cevimeline
  • Muscarinic receptor agonist
  • Miscellaneous indications

 

Term

Trusopt

Definition
  • Dorzolamide
  • Used to treat glaucoma
  • Carbonic anhydrase inhibitors 
  • Decrease production of aqueous humor

 

Term

Azopt

Definition
  • Brinzolamide
  • Used to treat glaucoma
  • Carbonic anhydrous inhibitor
  • Decrease production of aqueous humor

 

Term

Xalatan

Definition
  • Latanaprost
  • Used to treat glaucoma
  • Prostaglandin analogs
  • Increase uveoscleral outflow

 

Term

Hydroxyamphetamine

Definition
  • Adrenergic receptor agonist
  • Indirect-acting agent
  • Mydriatic (with Tropicamide-Paremyd)
  • Promotes the release of neurotransmitter by displacement from cytoplasmic pool

 

 

Term

Travatan

Definition
  • Travoprost
  • Used to treat glaucoma
  • Prostaglandin analogs
  • Increase uveoscleral outflow

 

Term

Lumigan

Definition
  • Bimatoprost
  • Used to treat glaucoma
  • Prostaglandin analogs
  • Increase uveoscleral outflow

 

Term

Pilocarpine

Definition
  • Pilocar
  • Isoptocarpine
  • Ocusert Pilo-20
  • Used to treat glaucoma
  • Muscarinic receptor agonist
  • Increase trabecular outflow

 

Term

Atropine

Definition
  • Muscarinic receptor antagonist
  • Use during ophthalmic procedures
  • Causes mydrasis and cycloplegia

 

Term

Homatropine

Definition
  • Muscarinic receptor antagonist
  • Use during ophthalmic procedures
  • Causes mydrasis and cycloplegia

 

 

Term

Mydriacyl

Definition
  • Tropicamide
  • Muscarinic receptor antagonist
  • Use during ophthalmic procedures
  • Causes mydrasis and cycloplegia

 

 

Term

Paremyd

Definition
  • Tropicamide/Hydroxyamphetamine
  • Muscarinic receptor antagonist
  • Use during ophthalmic procedures
  • Causes mydrasis and cycloplegia

 

 

Term

Cyclogyl

Definition
  • Cyclopentolate
  • Muscarinic receptor antagonist
  • Use during ophthalmic procedures
  • Causes mydrasis and cycloplegia

 

 

Term

Transderm-Scop

Definition
  • Scopolamine
  • Muscarinic receptor antagonist
  • Motion sickness
  • Cross the BBB and may cause drowsiness

 

Term

Atrovent

Definition
  • Ipratropium
  • Muscarinic Receptor antagonist
  • Used to treat pulmonary conditions-COPD and Asthma

 

Term

Spiriva

Definition
  • Tiotropium
  • Muscarinic Receptor antagonist
  • Used to treat pulmonary conditions-COPD and Asthma

 

Term

Cogentin

Definition
  • Benztropine
  • Muscarinic receptor antagonist
  • Adjunct for Parkinson's disease and treatment of extrapyramidal disorders caused by drugs that affect the CNS

 

Term

Artane

Definition
  • Trihexyphenidyl
  • Muscarinic receptor antagonist
  • Adjunct for Parkinson's disease and treatment of extrapyramidal disorders caused by drugs that affect the CNS

 

 

Term

Detrol

Definition
  • Tolterodine
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

Term

Ditropan

Definition
  • Oxybutynin
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

Enablex

Definition
  • Darifenacin
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

Vesicare

Definition
  • Solifenacin
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

Sanctura

Definition
  • Trospium
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

Toviaz

Definition
  • Fesoterodine
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

Uripas

Definition
  • Flavoxate
  • Muscarinic receptor antagonist
  • Treatment of overactive bladder

 

 

Term

ProBanthine

Definition
  • Propantheline
  • Muscarinic receptor antagonist
  • Treatment of gastrointestinal disorders (stomach/irritable bowel)/preoperative

 

 

Term

Bentyl

Definition
  • Dicyclomine
  • Muscarinic receptor antagonist
  • Treatment of gastrointestinal disorders (stomach/irritable bowel)/preoperative

 

 

Term

Robinul

Definition
  • Glycopyrrolate
  • Muscarinic receptor antagonist
  • Treatment of gastrointestinal disorders (stomach/irritable bowel)/preoperative

 

 

Term

D-Tubocurarine

Definition
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

 

Term

Nuromax

Definition
  • Doxacurium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

 

Term

Pavulon

Definition
  • Pancuronium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

 

Term

Nimbex

Definition

 

  • Cisatracurium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

Term

Zemuron

Definition

 

  • Rocuronium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

Term

Norcuron

Definition

 

  • Vecuronium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

Term

Mivacron

Definition

 

  • Mivacurium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

Term

Arduan

Definition

 

  • Pipecuronium
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Non-depolarizing blocking agents

 

Term

Anectine

Definition

 

  • Succinylcholine
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Depolarizing blocking agents

 

Term

Dantrium

Definition

 

  • Dantrolene
  • Muscarinic receptor antagonist
  • Neuromuscular blocking agents that leads to relaxation of skeletal muscle
  • Ryanodine receptor blocking agent used in malignant hyperthermia

 

Term

Levophed

Definition

 

  • Norepinephrine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Non-selective
    • α
    • α
    • β1
  • Miscellaneous Indications

 

Term

Adrenalin

Definition

  • Epinephrine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Non-selective
    • α1
    • α2
    • β1
    • β2
  • Miscellaneous indications

Term

Isuprel

Definition

  • Isoproterenol
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Non-selective
    • β1
    • β2
  • Miscellaneous indications

Term

Dobutrex

Definition

  • Dobutamine
  • Adrenergic receptor agonist
  • Direct-acting agonist
  • Non-selective
    • β1
    • β2 (slightly/some)
  • Treatment of refractory heart failure

Term

Corlopam

Definition

 

  • Fenoldopam
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Non-selective
    • D1
  • Treatment of severe hypertension

 

Term

Terbutaline

Definition

 

  • Brethine
  • Bricanyl
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Select
    • β2
  • Pulmonary disorders
  • Used to treat bronchospasm 
  • Used to treat pre-term contractions

 

Term

Albuterol

Definition

 

 

  • Ventolin
  • Proventil
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Select
    • β2
  • Pulmonary disorders 
  • Used to treat bronchospasm

 

 

Term

Serevent

Definition

 

  • Salmeterol
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Select
    • β2
  • Pulmonary disorders-used to treat bronchospasm
  • Long acting

 

Term

Foradil

Definition

 

 

  • Formoterol 
    • (and a component of Symbicort)
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Select
    • β2
  • Pulmonary disorders
  • Used to treat bronchospasm
  • Long acting

 

 

Term

Neosynephrine

Definition

  • Phenylephrine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
    • α1
  • Nasal/ophthalmic decongestant, mydriatic, vasoconstrictor

Term

Afrin

Definition

  • Oxymetazoline
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
    • α
  • Nasal/ophthalmic decongestant, mydriatic, vasoconstrictor

Term

Wytensin

Definition
  • Guanabenz
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
  • Use to treat hypertension 

 

Term

Tenex

Definition

 

  • Guanfacine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
  • Use to treat hypertension 

 

 

Term

Iopidine

Definition

 

  • Apraclonidine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
  • Use to treat glaucoma

 

Term

Alphagan P

Definition

 

  • Brimonidine
  • Adrenergic receptor agonist
  • Direct-acting agent
  • Selective
  • Use to treat glaucoma

 

Term

Pseudoephedrine

Definition

  • Adrenergic receptor agonist
  • Indirect-acting agent
  • Use as a nasal decongestant

Term

Intropin

Definition

  • Dopamine
  • Adrenergic receptor agonist
  • Mix-acting agents
    • D1
    • β1
    • α1 plus indirect

Term

Regitine

Definition

  • Phentolamine
  • Adrenergic receptor antagonist
  • Non-selective-alpha receptor
    • α1
    • α2
  • Use to treat hypertension

Term

Minipress

Definition

 

  • Prazosin
  • Adrenergic receptor antagonist
  • Selective- alpha receptor
    • α1
  • Use to treat hypertension

 

Term

Hytrin

Definition

  • Terazosin
  • Adrenergic receptor antagonist
  • Selective- alpha receptor
    • α1
  • Use to treat hypertension

Term

Cardura

Definition

  • Doxazosin
  • Adrenergic receptor antagonist
  • Selective- alpha receptor
    • α1
  • Use to treat hypertension

Term

Flomax

Definition

  • Tamsulosin
  • Adrenergic receptor agonist
  • Used to treatment benign prostatic hyperplasia

Term

Uroxatral

Definition

 

  • Alfuzosin
  • Adrenergic receptor agonist
  • Used to treatment benign prostatic hyperplasia

 

Term

Rapaflo

Definition

 

  • Silodosin
  • Adrenergic receptor agonist
  • Used to treatment benign prostatic hyperplasia

 

Term

Inderal

Definition
  • Propranolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine
Term

Corgard

Definition
  • Nadolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine
Term

Blocadren

Definition

 

  • Timolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

 

Term

Visken

Definition

  • Pindolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

Term

Levatol

Definition

  • Penbutolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

Term

Timoptic

Definition

  • Timolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat glaucoma

Term

Ocupress

Definition

 

  • Carteolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat glaucoma

 

Term

Betagon

Definition

 

  • Levobunolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat glaucoma

 

Term

OptiPranolol

Definition

 

  • Metapranolol
  • Adrenergic receptor antagonist
  • Non-selective-beta receptor
    • β1
    • β2
  • Use to treat glaucoma

 

Term

Tenormin

Definition

 

  • Atenolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Metoprolol

Definition

 

  • Lopressor
  • Toprol XL
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Sectral

Definition

 

  • Avebutolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Kerlone

Definition

 

  • Betaxalol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Zebeta

Definition

 

  • Bisprolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Brevibloc

Definition

 

  • Esmolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Bystolic

Definition

 

  • Nebivolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Alpha and beta receptor 
    • β1, release of nitric oxide
  • Use to treat various cardiovascular diseases & prophylactic treatment of migraine

 

Term

Betoptic S

Definition

 

  • Timolol
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat glaucoma

 

Term

Cosopt

Definition

 

  • Timolol/Dorzolamide
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat glaucoma

 

Term

Combigan

Definition

 

  • Timolol/Brimonidine
  • Adrenergic receptor antagonist
  • Selective-beta receptor
    • β1
  • Use to treat glaucoma

 

Term

Labetalol

Definition

 

  • Trandate
  • Normodyne
  • Adrenergic receptor antagonist
  • Alpha and Beta receptor
    • β1
    • β2
    • probably α1
  • Use to treat various cardiovascular disease

 

Term

Coreg

Definition

 

  • Carvedilol
  • Adrenergic receptor antagonist
  • Alpha and Beta receptor
    • β1
    • β2
    • possibly α1
  • Use to treat various cardiovascular disease

 

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