Term
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Definition
THC Analogue
(Nabilone)
Acts on cannabinoid receptors |
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Term
| LSD (Lysergic Acid Diethylamide) |
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Definition
Hallucinogen
- 5-HT2 partial agonist
- High degree of tolerance |
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Term
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Definition
Hallucinogen
Serotonin and dopamine agonist
From Peyote Cactus |
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Term
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Definition
Hallucinogen
3 Mechanisms:
- NMDA antagonist
- Sigma (opiod) agonist
- Dopamine and NE reputake inhibition |
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Term
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Definition
OTC Abuse
(cough suppressant)
NMDA antagonist |
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Term
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Definition
OTC Abuse
(motion sickness)
Anticholinergic |
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Term
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Definition
Activate dopamine
Side Effect - neurotoxicity, demyelination |
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Term
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Definition
Smoking Cessation
- often combined with other therapies
Antidepressant
- Decreases NE and Dopamine reuptake
- Weakly blocks dopamine, serotonin, and NE transporters |
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Term
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Definition
Smoking Cessation
- High affinity A4B2 nicotinic receptor partial agonist
- Moderate affinity 5HT-3 receptor agonist |
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Term
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Definition
Smoking Cessation
- Non-selective antagonist of non-A7 nicotinic receptors
- Crosses BBB
- Antihypertensive |
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Term
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Definition
MOA - ion-channel alteration
Ethanol --> alcohol dehydrogenase --> Acetaldehyde --> acetaldehyde dehydrogenase --> CO2 and H2O
Microsomal Ethanol Oxidizing System may be also have a role in alcohol metabolism with chronic use |
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Term
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Definition
(Wood Alcohol)
Metabolized to formaldehyde and formic acid
- Treat OD with ethanol, fomezapole, and dialysis
- Side effects - blindness, acidosis |
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Term
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Definition
Treat Methanol and Ethylene Glycol Intoxication
MOA - inhibits alcohol dehydroxylase |
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Term
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Definition
(Vitamin B1)
Treatment of CNS Alcohol Toxicity and Werkicke-Korsakof Syndrome |
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Term
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Definition
Treatment of Chronic Alcoholism
- Opiod receptor antagonist
- Decreases relapse |
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Term
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Definition
Treatment of Chronic Alcoholism
-5-HT3 antagonist |
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Term
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Definition
Treatment of Chronic Alcoholism
- AMPA (glutamate) antagonist and GABA modulator |
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Term
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Definition
Treatment of Chronic Alcoholism
- Acetaldehyde dehydrogenase antagonist
- Increases acetaldehyde --> hangover symptoms
- SE - Acetaldehyde Syndrome: Increased HR, hypotension, N/V, headache |
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Term
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Definition
Treatment of Alcohol Withdrawal
- Increases effects of GABA (benzodiazepine)
- Longer acting than Lorazepam |
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Term
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Definition
Treatment of Alcohol Withdrawal
- Increases effects of GABA (benzodiazepine)
- Shorter acting than Diazepam |
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