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Drugs for Endocrine Problems
Drugs for Endocrine Problems
30
Pharmacology
Undergraduate 1
05/05/2013

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Cards

Term
Hypothyroidism
Definition
Low thyroid function
"Hashimoto disease"
Causes low TH levels and symptoms of slow metabolism
Thyroid works harder and grows larger
Term
Myxedema
Definition
Severe form of hypothyroidism in adults
s/s include hair loss, firm & waxy skin, lethargy, seizures
Term
Cretinism
Definition
Hypothyroidism in neonates
Causes stunted physical growth and mental retardation
Term
Common signs and symptoms of hypothyroidism
Definition
Thickened skin, decreased cardiac and respiratory rates (main concern), weight gain, loss of appetite, anorexia, muscle weakness, lethargy
Term
TH Replacement Drugs and their intended responses
Definition
levothyroxine sodium (Synthroid, Levoxyl)
liothyronine sodium (Cytomel, Triostat)
Intended responses: Normal vital signs, maintain body weight, mental alertness, intact memory, normal bowel movement pattern
Term
Effects of TH Replacement Drugs on other medications
Definition
-Enhance the action of Coumadin (increased bleeding)
-Decrease levels of Lonoxen
-Decrease effects of diabetic medication
Term
Side effects of TH Replacement Drugs
Definition
Tachycardia, hypertension, warm skin, insomnia, increased bowel movements
Term
Adverse effects of TH Replacement Drugs
Definition
Angina, heart attack, heart failure, seizures
Term
Patient teaching related to TH Replacement Drugs
Definition
-Dosage is slowly increased over 2 to 3 weeks
-Take exactly as prescribed
-Take pulse at scheduled times: before taking drug and before bedtime
-Do not take with a fiber supplement as it decreases the effects of the drug
-If HR increases by 20 beats/min in 1 week contact physician
Term
Lifespan Considerations for TH Replacement Drugs
Definition
Pediatric: Safe; medication adjusted with growth spurts
Pregnancy and breastfeeding: Category A; may need higher doses; avoid breastfeeding
Older Adults: More likely to experience adverse cardiac/nervous system effects
Follow-up every 3 to 6 months
Patients with diabetes may need higher doses of insulin; frequent blood glucose level checks
Term
Hyperthyroidism
Definition
Overactive thyroid
Caused by: Graves' disease, tumors, excessive thyroid growth, excessive iodine
Also called: thyrotoxicosis (d/t affecting all organs)
Faster metabolism
Term
Graves' Triad
Definition
Cause of overactive thyroid
Must have 3 components: Goiter, peritibal edema (swelling of lower legs but not pitting edema), exophalamos (bugging of eyes)
Term
Common signs and symptoms of hyperthyroidism
Definition
-Skin hot and dry
-Increased cardiac and respiratory rates
-Weight loss/hair loss
-Increased appetite (but loses weight)
-Muscle weakness
-Nervousness
-Irritability
-Unable to sleep well
-Tremors
-Altered menstrual flow
Term
Treatment of Hyperthyroidism
Definition
Treatments destroys part/all of thyroid gland by:
-Surgery (thyroidectomy)
-radiation (need to stay home for 48 hours due to being radioactive
Term
Thyroid-suppressing drugs (for HYPERthyroidism)and their intended responses
Definition
Drugs reduce hormone production prior to surgery
-methimazole (Tapazole)
-propylthiouracil (PTU)
Intended response: Normal everything
Term
Sides effects of thyroid-suppressing drugs
Definition
Rash, nausea, headache, muscle/joint aches
Term
Adverse effects of thyroid-suppressing drugs
Definition
Bone marrow suppression (which leads to decreases RBCs which leads to anemia and increase risk for infection), hepatotoxicity, enhances activity of Coumadin
Term
What to check before and after administering thyroid-suppressing drugs
Definition
Check before: Vital signs, liver function tests
Check after: Blood counts; assess for jaundice (due to hepatotoxicity)
Term
Patient teaching related to thyroid-suppressing hormones
Definition
-Medical follow-up
-Regular monitoring of blood counts (INR)
-Avoid crowds due to decreased immunity
-Monitor for jaundice; report if present
s/s of jaundice: yellow discoloration of white part of eyes and skin
-Avoid food high in iodine
Term
Life Span Considerations for thyroid-suppressing drugs
Definition
Pediatric: NOT USED UNDER AGE OF 6; use with caution on short-term basis
Pregnancy & Breastfeeding: NOT USED Category D; causes miscarriages; avoid during breastfeeding
Older adults: Severe adverse effects more likely
Term
Parathyroid
Definition
located behind the thyroid gland with one on each side; Parathyroid hormone (PTH) is secreted in response to a reduction in serum calcium levels
Term
Hypo-parathyroid hormone
Definition
Need calcitriol to increase calcium absorption; vitamin D supplements may be given (assists in the absorption of calcium and bone resorption)
Term
Tips for patients with thyroid disorders
Definition
-Too high of a dose will result in nervousness, irritability, and insomnia
-Keep a log of pulse, weight, and mood status
-For patients with hyperthyroidism: avoid foods high in iodine, such as soy, tofu, turnips, seafood, and iodized salt
-Immediately report chest pain
-Synthroid takes several weeks to months to reach a therapeutic level (lab tests every 6-12 months after therapeutic level)
Term
Perimenopause
Definition
transition time from normal periods to no periods for a full year
Term
Effects of high level of follicle stimulating hormone (FSH)
Definition
-dilated blood vessels
-hot flashes/night sweats
-decreased mental concentration
Term
Effects of low estrogen levels
Definition
-Cause unpleasant changes in skin, vaginal tissues
-Increased rate of bone loss (osteoporosis)
Term
Hormone Replacement Therapy (HRT) and their intended responses
Definition
-conjugated estrogens (Premarin)
-methroxyPROGESTERone (Premphase, Prempro)

Intended Response: Replace naturally secreted estrogen/progesterone with exogenous hormones during perimenopausal period
-Reduce number, severity of hot flushes/night sweats
-Reduce vaginal dryness
Term
Side effects of Hormone Replacement Therapy (HRT)
Definition
breast tenderness, breakthrough bleeding, fluid-retention weight gain, acne
Term
Adverse effects of Hormone Replacement Therapy (HRT)
Definition
increased blood clotting, hormone-sensitive cancers; liver impairment; gallbladder disease; pancreatitis
Term
Patient teaching related to Hormone Replacement Therapy (HRT)
Definition
-take exactly as prescribed
-annual screenings for breast, cervical, uterine, ovarian cancer
-smoking cessation
-monitor/report symptoms of jaundice
-seek medical attention for: chest pain, difficulty breathing, swelling in one leg (blood clot), symptoms of a stroke
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