Term
| Pathophysiology and s/sx: Parkinson's disease |
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Definition
Pathophysiology: degeneration of dopaminergic neurons, lack of dopamine neurotransmitter. Secondary excessive AcH
S/Sx: muscle rigidity, bradykenisia, tremors |
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Term
| Drug Action: Drugs for Parkinson's |
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Definition
| Decrease dopaminergic degredation, increase dopamine concentration, regulate excessive AcH |
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Term
| Drug Classes: Drugs for Parkinson's |
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Definition
Classes include:
-Anticholinergics- reduce rigidity and tremors, no effect on bradykenisia
-Dopaminergics: Increase Dopamine Levels
-Dopamine agonists: Stimulate dopamine receptors
-MAO-B Inhibitors- Inhibits MAO-B enzyme; MAO-B degrades dopamine
-COMT Inhibitors- Inhibits COMT enzyme; COMT enzyme inactivates dopamine |
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Term
| SubClass: Anticholinergic |
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Definition
Class: Drugs for Parkinson's Disease
Drug Action: Decreases the levels of AcH
Therapeutic effect: reduce rigidity and tremors, no effect on bradykenisia
Drugs include:
Trihexyphenedyl (Artane)
Benztropine (Cognetin) |
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Term
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Definition
Generic: Trihexyphenedyl
Subclass: Anticholinergic
Class: Drugs for Parkinson's
Note: Decrease rigidity, no effect on bradykenisia |
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Term
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Definition
Generic: Benztropine
Subclass: Anticholinergic
Class: Drugs for Parkinson's
Note: Decrease rigidity, no effect on bradykenisia |
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Term
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Definition
Class: Drugs for Parkinson'
Increases levels of dopamine
Levodopa (l-dopa)
Carbidopa-levodopa (sinemet) |
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Term
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Definition
Generic: L-Dopa
Class: drug for Parkinson's
Subclass: Dopaminergic
Notes: First used, but needs high dose |
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Term
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Definition
Generic: Carbidopa-Levadopa
Class: Drug for Parkinson's
Subclass: Dopaminergics
Notes: Newer drug, allows more dopamine to reach the brain |
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Term
| Subclass: Dopamine Agonist |
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Definition
Class: Drugs for Parkinson's
Notes: stimulates dopamine receptors
Drugs include:
Amatadine Hcl (Symmetrel)
Bromocriptine mesylate (Parlodel) |
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Term
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Definition
Generic: Amantadine Hcl
Class: Drugs for Parkinson's
Subclass: Dopamine Agonist
Notes: Antiviral drug that acts on dopamine receptors |
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Term
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Definition
Generic:Bromocriptine mesylate
Class: Drugs for Parkinson's
Subclass: Dopamine Agonist
Notes: Given to clients who cannot tolerate L-Dopa or Sinamet
Increased side effects |
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Term
| Subclass: MAO-B Inhibitors |
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Definition
Class: Drug for Parkinson's
Drug Action: Inhibits MAO-B Enzyme
Drug's include:
Seligeline (Eldepryl) |
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Term
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Definition
Generic: Seligeline
Class: Drugs for Parkinson's
Subclass: MAO-B inhibitor
Notes- Used when L-dopa or Sinemmet donet work. Last resort because of liver toxicity |
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Term
| Subclass: COMT Inhibitors |
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Definition
Class: Drug for Parkison's
Drug action: Inhibits COMT enzyme, which degrades dopamine
Drugs include:
Tolcapone (Tasmar)
Entacapone (Comtan) |
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Term
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Definition
Generic: Tolcapone
Class: Drug for Parkinson's
Subclass: COMT inhibitor |
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Term
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Definition
Generic: Entacapone
Class: Drug for Parkinson's
Subclass: COMT inhibitor
Notes: More common than Tasmar
Very toxic to liver, last choice |
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Term
| Side effects: Drugs for Parkinson's |
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Definition
Dry mouth, urine retention, constipation
Serious Adverse Effects: liver toxicity |
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Term
| Assessment: Drugs for Parkinson's |
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Definition
Assess liver enzymes
Drugs are contraindicated for individuals with liver problems |
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