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Drugs and Spectrum
Infectious Disease Drugs and Spectrum
46
Pharmacology
Professional
10/20/2011

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Term
Gentamicin
Definition
Aminoglycoside
good against G- (including Pseudomonas)
Term
Tobramycin
Definition
Aminoglycoside
good against G-; better than Gent against Pseudomonas, but lacks Enterococci coverage
Term
Amikacin
Definition
Aminoglycoside
good against most G- (including Pseudomonas) also not Enterococci
Term
Streptomycin
Definition
Aminoglycoside
2nd line for TB...mycobacterium
Term
Tetracycline
Definition
Tetracycline
Broad against G+, G-, anaerobes(NOT C.diff), Atypicals
Term
Minocycline
Definition
Tetracycline
Broad against G+, G-, Anaerobes(NOT C.diff), Atypicals
**CNS infections
Term
Doxycycline
Definition
Tetracycline
broad against G+,G-,anaerobes(NOT C.diff), Atypicals
CA-MRSA coverage!
Term
Tigecycline
Definition
Glycylcyclines
Broad against G+,G-(Not Pseudomonas or Proteus),anaerobes(YES C.diff), Atypicals
*MSSSA, HAMRSA, CAMRSA, VRE
Term
Erythromycin
Definition
Macrolides
Broad G+,G-(NOT H.influ), atypical (esp CAP)
Term
Clarithromycin
Definition
Macrolide
Broad G+,G-(some H.influ),atypicals
*overall better than Erythromycin
Term
Azithromycin
Definition
Macrolides
Less G+, more G-(esp resp infections: H.influ,Moraxella)
Possible for CAP, pharyngitis, sinusitis, STDs, Skin infections
Term
Telithromycin
Definition
Ketolides
Good against G+, G-(esp CA resp: H influ, Moraxella), Atypicals
Term
Clindamycin
Definition
Lincosamides
against serious G+(including CAMRSA, but not HAMRSA or Enterococci)
also good against anaerobes(NOT C.diff)
Term
Quinupristin/Dalfopristin
Definition
Streptogramins
good against G+(including PRSP, HAMRSA, VRE but not E. faecalis), some atypicals
Term
Chloramphenicol
Definition
Choramphenicol
broad against G+,G-, anaerobes, atypicals
*CNS infections
Term
Linezolid
Definition
Oxazolidinones
against G+ mostly (including HAMRSA, PRSP,VRSA,VRE)
against G-,anaerobes, atypicals BUT NOT used...
Term
Levofloxacin
Definition
Fluoroquinolones
good G- (including Pseudomonas),G+(esp S. pneumo, but not MRSA), atypicals
Term
Moxifloxacin
Definition
Fluoroquinolones
good G- (including some Pseudomonas),G+(esp S. pneumo, but not MRSA), atypicals
**Anaerobe coverage...but not preferred agent for this!(NOT C.diff)
Term
Gemifloxacin
Definition
Fluoroquinolones
G+(esp S. pneumo, but not MRSA), atypicals
**not as good on G- as other FQs
Term
Nitrofurantoin
Definition
Nitrofurans
Narrow against G+(sensitive Strep, Enterococci),G-(E.Coli, Proteus, Pseudomonas, but NOT many Enterobacter,or Klebsiella)
**ONLY used in UTIs
Term
Metronidazole
Definition
Nitroimidazoles
good against anaerobes(YES C.diff), Microaerophils(Helicobacter, Campylobacter),parasites(Trichomonas, Giardia, Entamoeba)
Term
Rifampin, Rifabutin, Rifapentine, Rifaximin
Definition
Rifamycins
broad against G+,G-(including some Pseudomonas), atypicals (NOT mycobacterium fortuitum)
Term
Sulfamethoxazole (SMZ)
Definition
Sulfonamides
broad against G+,G-
Term
Cotrimoxazole
Definition
Antimetabolite Combo
broad against G+(S.pneumo, H.influ, CAMRSA, but NOT Enterococci, HAMRSA, Group A Strep),G-
*also Pneumocystis jirovecii(AIDs pneumonia)
Term
Fidaxomicin
Definition
Macrocyclics
Narrow against G+,G+ anaerobes(YES C.diff)
Term
Daptomycin
Definition
Lipopeptides
good against G+(including HA/CAMRSA, VRSA, possibly VRE)
Term
Colistin
Definition
Polymixins
G-
Term
Pen G and Pen V
Definition
Natural Penicillins
good against G+, G-, G+anaerobes(NOT C.diff)
Term
Oxacillin,Cloxacillin, Dicloxacillin, Nafcillin
Definition
Antistaphylococcal Penicillins
G+ Staph resistant to Pen G(MRSA)
Term
Ampicillin/Amoxicillin
Definition
Aminopenicillins
Better than Pen G against G-(Not Pseudomonas), some G+, anaerobes(NOT C.diff)
Term
Carbenicillin, Ticarcillin, Mezlocillin, Piperacillin
Definition
Antipseudomonal Penicillins
Better than Pen G against G-(including Pseudomonas), anaerobes(NOT C.diff)
Term
Cephalexin, Cefazolin, Cephradine, Cefadroxil
Definition
1st Gen Cephs
Strong G+, G-(PEcK)
Term
Cefuroxime, Cefaclor, Cefprozil, Loracarbef
Definition
2nd Gen Cephs(Non-cephamycins)
Some G+, G- (HENPEcK)
*respiratory infections
Term
Cefotetan, Cefoxitin
Definition
2nd Gen Cephs - Cephamycins
limited G+, some anaerobic or facultative G-
Term
Cefdinir, Cefixime
Definition
3rd Gen Cephs
moderate G+, enhanced G- (not Pseudomonas)
Term
Cefotaxime, Ceftriaxone
Definition
3rd Gen Cephs
Strep pneumo (CAP)
Term
Ceftizoxime
Definition
3rd Gen Cephs
Anaerobes(NOT C.diff)
Term
Ceftazidime
Definition
3rd Gen Cephs
Pseudomonas
Term
Cefepime
Definition
4th Gen Cephs
extended G+(esp S.pneumo),Strong G-(esp Pseudomonas)
Term
ceftaroline
Definition
5th Gen Cephs
G+(CAP,MRSA)
Term
Aztreonam
Definition
Monobactam
ONLY against G- (including Pseudomonas)
Term
Ertepenem
Definition
Carbapenem
against G+(less than other carbapenems; NOT Enterococci),G-(NOT Pseudomonas),and anaerobes(NOT C.diff)
*resistant to B-lactamases
Term
Imipenem
Definition
Carbapenems
Broad against G+,G-(esp Pseudomonas),anaerobes (NOT C.diff)
*resistant to B-lactamases
Term
Doripenem
Definition
Carbapenems
Broad against G+,G-(best carbapenem for Pseudomonas),anaerobes (NOT C.diff)
*resistant to B-lactamases
*needs more clinical use and experience
Term
Vancomycin
Definition
Glycopeptides
against G+(HA/CAMRSA, PRSP, MRSE)
against anaerobe, C.diff
*Vanc resistance has arisen in Staph and Enterococci
*given PO for GI infection
Term
Televancin
Definition
Glycopeptides
against MRSA, PRSP
*Vanc resistance has arisen in Staph and Enterococci
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