Term
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Definition
2nd Generation oral bisphosphonate:
1. taken up as bad atp --> apop
2. inhibits farynsel pyrophosphate syntase which builds membrane anchors
CAUSES HORRIBLE GI IRRITATION (must take in morning with watern remain up)
ACUTE PHASE RXN FEVER FOR IV
OSTEONECROSIS JAW (super rare)
ATYPICAL FEMUR FRACTURE (rare)
TERATOGEN
Contraindicated renal disease because renally eliminated
also good for bone mets!
re-eval 3-5 |
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Term
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Definition
3rd Generation IV bisphosphonate:
1. taken up as bad atp --> apop
2. inhibits farynsel pyrophosphate syntase which builds membrane anchors
CAUSES HORRIBLE GI IRRITATION (must take in morning with watern remain up)
ACUTE PHASE RXN FEVER FOR IV
OSTEONECROSIS JAW (super rare)
ATYPICAL FEMUR FRACTURE (rare)
TERATOGEN
Contraindicated renal disease because renally eliminated
also good for bone mets!
re-eval 3-5 |
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Term
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Definition
Human monoclonal antibody against RANKL
-injected sc t1/2 = weeks
-good for mets cytokins as well
1. osteonecrosis jaw
2. musculoskeltal pain (not acute rxn)
3. contra pregnant
4. INCREASES SEVERITY T-CELL INFECTION |
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Term
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Definition
PTH analog that induces osteoblast differentiation, maturation, and avoids apoptosis
1. reserved to high risk due to cost
2. contraindicated in mets and hypercalcemia (due to too long PTH)
3. may cause osteosarcoma so avoid high risk patient
dose 2-3 years only |
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Term
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Definition
Selective Estrogen Receptor Modulator
agonist bone/liver
antagonist breast (prevents cancer)
neutral uterus (no increase cancer)
1. INCREASES THROMBOEMBOLIC RISK
2. AGGREVATES CRAMPS/HOT FLASHES
good: mid osteoporosis, breast cancer
bad: stroke/DVT vasomotor spasms pregnant
mainly inhibits osteoclasts, mainly vertebral |
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Term
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Definition
RANKL- activates osteoclast
osteoprotegrin = autocrine blocker RANKL |
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