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Drug Therapy Migrainese
For pharm
9
Medical
Professional
02/14/2013

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Cards

Term
Triptans
Definition
Almotriptan
Eletriptan
Frovatriptan
Naratriptan
Rizatriptan
Sumatriptan
Zolmitriptan
Term
Ergot Derivatives
Definition
Ergot Alkaloid
Dihidroergotamine
Term
Prophylaxis Migraines
Definition
B Blockers
Anti-epileptics (valproic acid)
Tricyclic anti-depressants (amytryptiline)
BUTTERBAR HERB
Term
Rescue from migraines
Definition
Opioids
Anti-emetics
Term
Acute Migraine Relief
Definition
Non-opioid analgesics
Combo:
Aspirin/acetaminophen/caffeine
Aspirin/butalbital/caffeine
Term
Sumatriptan
Definition
Migraine prototypical drug
5HTb/d antagonist promotes vasoconstrict meninges and inhibits 5HT release neurons
ALSO Presynaptic autoreceptor agonist on TRIGEM and CNS

Side effects: chest pressure/tightness
Contraindication: Coronary Artery Disease, SSRI, MAOI

Frovatriptan is longest lasting possible prophylactic
Term
Rules migraine
(number acute/week)
(combo analgesics)
Definition
Exercise regularly
 Avoid combination analgesics
 Use acute treatments no more than 2X/week
Term
Egotamine
Definition
MIGRAINE:Largely a pressor and hallucinogen through serotonin (5HT) system...Dopamine (DA) D2 receptor agonist- resulting nausea and vomiting results in metoclopromide to counter

Litany of toxicities: hallucination, vasospasm, parasthesia, gangrene, abortion.
Term
dihyrdroergotamine
Definition
sublingual or nasal spray for migraines

Poorly/erratically absorbed in different people/ at different times

Ergot family
 Acute Vasospasm/ Gangrene
 Hallucinations
 Abortion
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