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Drug Target Enzymes
Study
30
Pharmacology
Graduate
04/30/2013

Additional Pharmacology Flashcards

 


 

Cards

Term

Clavulanic Acid

 

Molecular Target

Definition
B(Beta)-Lactamase
Term

Clavulanic Acid

 

MOA

Definition
Irreversible Inhibitor
Term

Clavulanic Acid

 

Disease/Symptoms

Definition
Anti-Bacterial agent used in combination with penicillin overcoming drug resistance
Term

Muscarine

 

Molecular Target

Definition
Muscarinic Receptor
Term

Muscarine

 

MOA

Definition
Agonist
Term

Muscarine

 

Disease/Symptom

Definition
Glaucoma
Term

Atropine

 

Molecular Target

Definition
Muscarinic Receptor
Term

Atropine

 

MOA

Definition
Antagonist
Term

Atropine

 

Disease/Symptoms

Definition
Used to treat organophosphate poisoning, and resuscitation
Term

Neostigmine

 

Molecular Target

Definition
Acetylcholinesterase
Term

Neostigmine

 

MOA

Definition
Reversible Inhibitor
Term

Neostigmine

 

Disease/Symptoms

Definition
Used to treat myasthenia gravis (an autoimmune disease)
Term

Nerve Gase Agents: Sarin, Tabun, DFP, and VX

 

Molecular Target

Definition
Acetylcholinesterase
Term

Nerve Gase Agents: Sarin, Tabun, DFP, and VX

 

Molecular Target

Definition
Acetylcholinesterase
Term

Nerve Gase Agents: Sarin, Tabun, DFP, and VX

 

MOA

Definition
Irreversible Inhibitors
Term

Nerve Gase Agents: Sarin, Tabun, DFP, and VX

 

Disease/Symptoms

Definition
None but are used in war as chemical war agents and by terrorists
Term

Pralidoxime

 

Molecular Target

Definition
Acetylcholinesterase
Term

Pralidoxime

 

MOA

Definition
Antidote used to remove irreversible organophosphate inhibitors from AChE
Term

Pralidoxime

 

Disease/symptoms

Definition
Organophosphate poisoning
Term

Pyridostigmine

 

Molecular Target

Definition
Acetylcholinesterase
Term

Pyridostigmine

 

MOA

 

Definition
Prophylactical to block or prevent organophosphate poisoning
Term

Pyridostigmine

 

Disease/Symptoms

Definition
Used to prevent organophosphate poisoning but has been linked to Gulf War Syndrome
Term

Imatinib (Gleevac)

 

Molecular Target

Definition
BCR-ABL
Term

Imatinib (Gleevac)

 

MOA

Definition
Competitive BCR-ABL Inhibitor
Term

Imatinib (Gleevac)

 

Disease/Symptoms

Definition
Used to treat various types of cancer but mainly Leukemia  including: ALL, CEL, CML
Term

Dasatinib (Sprycel)

 

Molecular Target

Definition
BCR-ABL
Term

Dasatinib (Sprycel)

 

MOA

Definition
Binds to the active form of ABL
Term

Dasatinib (Sprycel)

 

Disease/Symptoms 

Definition
Used to treat Imatinib resistant Leukemia that is Philadelphia chromosome positive
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