Term
| What are 2 Physicochemical Parameters? |
|
Definition
|
|
Term
| What are 3 Physicochemical Parameters of Drugs? |
|
Definition
• Hydrophilic Drugs
• Hydrophobic Drugs
• Weak Acid or Weak Base |
|
|
Term
| Describe rate of release for Hydrophilic Drugs and what they are used for |
|
Definition
– Rapid rate of release
– Used for more immediate release |
|
|
Term
| Describe rate of release for Hydrophobic Drugs and what they are used for |
|
Definition
– Delayed release
– Used for extended release or depot preparations |
|
|
Term
| What do Weak Acid or Weak Bases affect? |
|
Definition
| – Affects rate of release at site of absorption |
|
|
Term
| What are the 2 sub categories of Physicochemical Parameters of Dosage Form? |
|
Definition
• Type of Delivery System
• Excipients Used |
|
|
Term
| What are the types of Delivery Systems? |
|
Definition
– Immediate release or Extended Release
– Transdermal, oral |
|
|
Term
|
Definition
– Disintegrants
– Fillers
– Lubricants
– Polymers |
|
|
Term
| For the Role of Excipients disintegrating agents are generally used to promote ________ of oral solid dosage forms in order to release the ________ ___________ |
|
Definition
| disintegration, active ingredients |
|
|
Term
| For the Role of Excipients Diluents play a very important role in tablet ________, _________, _________ and biopharmaceutical properties of tablets. |
|
Definition
| hardness, disintegration, dissolution |
|
|
Term
| Under the same _______ force, tablets made of a same active ingredient but with different diluents have _______ ________ |
|
Definition
| Compressional, different hardness. |
|
|
Term
| If the same tablets were made by different starches, the dissolution rate profile is .... |
|
Definition
|
|
Term
| Hardness of a tablet varies based on the ... |
|
Definition
|
|
Term
| Disintegration time of a tablet varies based on the ... |
|
Definition
|
|
Term
| Lubricants such as magnesium stearate ______the dissolution of drug |
|
Definition
|
|
Term
| Polymers used in preparation of matrix based systems change the release profile of drugs based on ... |
|
Definition
|
|
Term
| Hydrophilic polymers are used for ... |
|
Definition
|
|
Term
| hydrophobic are used for ... |
|
Definition
|
|
Term
| Polymers used in coating process also change ... |
|
Definition
|
|
Term
| Film coating polymers _____ the release of a drug for extended periods of time |
|
Definition
|
|
Term
| Presence of food in the stomach can______ the release of drug |
|
Definition
|
|
Term
| Enteric coated tablets release the contents only at the pH of the ... |
|
Definition
|
|
Term
| pH sensitive liposomes undergo a pH induced fusion with _________ _________and directly release the liposomal content to the ________ |
|
Definition
| endosomal membrane , cytosol |
|
|
Term
| These liposomes are stable at physiological pH and undergo degradation or deformation at _____ pH. |
|
Definition
|
|
