Term
| Molded tablets are also called ___ |
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Definition
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Term
| Molded tablets are small round masses of molded powders weighing ____ |
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Definition
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Term
| Molded tablets have 4 main rapidly soluble vehicles such as ___/___/___/___ |
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Definition
lactose
beta-lactose
mannitol
dextrose |
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Term
| Since these tablets are intended to dissolve rapidly, tablet triturates (also called ___) are generally ___ than compressed tablets |
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Definition
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Term
| Nitroglycerin is for ___ administration |
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Definition
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Term
| Potent ___ and other drugs are formulated as molded tablets to be used as ___ tablets for compounding or for making solutions |
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Definition
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Term
| Molds consist of 2 plates made from ___ or ___ |
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Definition
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Term
| One of the plates that make up molds contains ___ perforations; while the other plate is fitted with the corresponding ___ that fit the perforations |
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Definition
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Term
| The perforated plate of molds is placed on a flat surface ___ and the moistened mass is forced into the ___ with a broad spatula. Any excess material is scraped from the ___ |
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Definition
glass plate
perforations
top surface |
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Term
| The plate (from molds) with filled perforations is then allowed to stand in a position such that part of the moistening agent will ___ ___ from both faces of the tablet triturates |
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Definition
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Term
| The plate (in molds) us subsequently placed over the plate with the pegs and is gently ___ ___ |
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Definition
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Term
| As the plates (from molds) are fitted together, the pegs force the tablet triturates from the perforations and they are allowed to ___ |
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Definition
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Term
| In some molds, the pegs are forced down onto the ___ holding the moist triturates |
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Definition
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Term
| In preparation of moistened mass, the drug and diluent are moistened with a mixture of water and ___ or other solvents |
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Definition
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Term
| Usually ___ is used as the moistening agent in preparations of a moistened mass |
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Definition
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Term
| If too much solvent mixture is added, a ___ is produced and it requires longer time for drying |
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Definition
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Term
| The finished tablet will also be hard and ____ |
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Definition
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Term
| Also, ___ will occur. As the solvent evaporates, the drug moves to the ___ of the tablet |
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Definition
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Term
| Because of the ___ of tablet triturates, drug at the surface may be lost resulting in an inaccurate ___ in the tablet |
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Definition
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Term
| If an insufficient amount of moistening agent is used, proper ___ of the mass will be lacking and a ___ tablet cannot be produced |
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Definition
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Term
Machine molding tablet trituates
These are prepared using compression tablet machines with ___-faced punches |
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Definition
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Term
| If solubility and clear solutions are required, ___ lubricants are used |
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Definition
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Term
| Granulations are prepared as in conventional ___ |
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Definition
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Term
| Generally, ___ is the diluent |
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Definition
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Term
| The resultant tablets are not as satisfactory as the ones prepared by ___ |
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Definition
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Term
| Tablet hardness (___ ___) determines the resistance of the tablet to ___, ___, or ___ under conditions of storage, transportation, and handling before use |
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Definition
crushing strength
chipping
abrasion
breakage |
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Term
| In the past, a simple rule of thumb was used to assess whether the tablet had the proper hardness: firm enough to break with a sharp snap when positioned between the 2nd and 3rd fingers using the thumb as the ___, yet did not break upon ___ on a hard floor |
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Definition
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Term
| Nowadays, ___ are used to quantitate the degree of hardness |
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Definition
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Term
| The Monsanto hardness tester measures the force required to break the tablet, the force is generated by a ___, which is applied ___ to the tablet |
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Definition
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Term
| This device measures in ___, a hardness of ___ is the minimum required for a satisfactory tablet |
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Definition
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Term
| The Strong-Cobb hardness tester uses force diametrically applied and produced by a manually operated ___ |
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Definition
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Term
| This dial for the air pump is calibrated into ___ arbitrary units |
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Definition
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Term
| The Pfizer hardness tester uses the same mechanical principle as in ordinary ___ is utilized |
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Definition
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Term
| The hardness is read from a dial in ___ as the tablet breaks under the diametrically applied force |
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Definition
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Term
| The Scheuniger hardness tester is the one that is ___ |
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Definition
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Term
| This one is ___ operated, thus eliminating operator ___ |
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Definition
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Term
| Tablets are not suppose to be neither too ___ or too ___ |
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Definition
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Term
| If the tablet is too hard, it may not ___ during the appropriate time interval or meet the dissolution specification |
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Definition
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Term
| On the other hand, if it is too soft it will not stand a handling during subsequent processes such as ___, ___, and ___ |
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Definition
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Term
| Friability is related to hardness and is measured using the ___ |
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Definition
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Term
| The abolity of the tablet to withstand ___ is packaging, shipping, and handling is evaluated |
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Definition
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Term
| A certain number of tablets are weighed and placed in the apparatus where they are exposed to ___ and repeat shocks as they ___ within the friabilator |
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Definition
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Term
| After a given number of rotations, the tables are retrieved and weighed to determine the ___ which serves as a surrogate for friability |
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Definition
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Term
| The shipping test is for new products and the package is sent to distant points and back using various means of ___ |
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Definition
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Term
| The conditions of the product upon return is indicative of its ability to withstand ___ during transportation |
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Definition
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Term
| Tablet thickness can vary in the ___ of the granulation, compression ___, or ___ of tablet compression is changed. ___ is important |
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Definition
density
pressure
speed
thickness |
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Term
| In the packaging operation, a column containing a known number of tablets is measured for ___ |
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Definition
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Term
| If the thickness changes, the number of tablets in the column will be ___ |
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Definition
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Term
| This thickness is measured by a ___ (thickness gauge) |
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Definition
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Term
| Plus or minus ___ may be allowed depending on the ___ of the tablet |
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Definition
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Term
| The volumetric fill of the ___ determines the weight of the tablet |
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Definition
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Term
| During compression, the weight is checked routinely (manually or electronically to ensure ___) |
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Definition
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Term
| The ___ provides tolerances for weight variation in ___ tablets |
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Definition
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Term
| This is applicable when the tablet contains ___ of drug comprising ___ by weight of the tablet |
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Definition
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Term
| ___ are weighed individually, and the average weight is calculated |
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Definition
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Term
| Not more than ___ of the tablets should differ in weight from the average weight by more than the ___ specified in the table; but none differs by more than ___ percentage |
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Definition
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Term
| ___ are exempt from this requirement |
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Definition
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Term
AVERAGE WEIGHT %difference
130 mg/less ___
130-324mg ___
more than 324 ___ |
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Definition
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Term
| Content uniformity is to ensure that the tablets contain the amount of drug ___, with little variation among the tablets |
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Definition
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Term
| The USP test is applicable to to both coated and uncoated tablets and all ___ intended for oral delivery where the range of drug content in the dosage form unit includes ___ or less |
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Definition
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Term
| The required number of units are ___ assayed (in this content uniformity test) |
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Definition
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Term
| Tablets with a content uniformity requirement are exempt from a ___ test |
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Definition
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Term
| The tablet disintegration test is a measure of the time required for a group of tablets to disintegrate into particles under a given ___ |
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Definition
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Term
| These type of tablets are used for oral conventional (___), except for ___ tablets |
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Definition
non-sustained release
chewable |
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Term
| The test is used for quality assurance test: ensures that a given tablet formulation is the same with respect to disintegration from ___ |
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Definition
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Term
| The apparatus consists of a basket rack holding ___, open at the top AND bottom |
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Definition
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Term
| The bottom of the basket is covered with a ___ |
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Definition
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Term
| The basket rack is immersed in a suitable aqueous medium (___ or ___) and the temperature is held at ___ degrees Celsius |
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Definition
water or simulated gastric fluid
37 |
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Term
| This stuff is usually inside a one liter ___ |
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Definition
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Term
| The rack will move in an ___ motion |
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Definition
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Term
| The screen remains at least ___ below the fluid surface and when it moves down it is still at least ___ form the bottom of the beaker |
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Definition
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Term
| One tablet is placed in each of the 6 tubes; a ___ is added over the tablet, unless otherwise specified |
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Definition
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Term
| The plastic disc will force any ___ through the screen |
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Definition
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Term
| Then endpoint is when any residue in the tubes is a soft mass with no palpably ___ |
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Definition
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Term
| If one or two tablets fail to disintegrate, the test is repeated with ___ |
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Definition
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Term
| Of the 18 tablets, ___ must disintegrate within the specified time in the monograph |
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Definition
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Term
| The test conditions are varied for ___, ___, and ___ tablets |
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Definition
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Term
| For most coated tablets, disintegration time is about ___ |
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Definition
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Term
| For coated tablets, up to ___ may be required |
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Definition
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Term
| For sublingual tablets such as Isosorbide Dinitrate Sublingual Tablets USP, the time is ___ |
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Definition
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Term
| Ascorbic Acid Tablets USP, the time is ___ |
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Definition
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Term
| Methylcellulose Tablets USP time is ___ |
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Definition
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Term
| In the dissolution test,for drug absorption and bioavailability, the drug must be in the ___ state |
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Definition
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Term
| Therefore, satisfactory ___ characteristics are an important requirement for a successful tablet |
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Definition
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Term
| The dissolution test measures the amount of time required for a certain percentage of ___ in the tablet to dissolve under specified set of conditions |
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Definition
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Term
| It is intended to provide a step toward evaluation of the ___ of the drug |
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Definition
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Term
| It is the quality assurance tool to make certain that the tablets made are similar from ___ to those initially used in determining bioavailability and clinical effectiveness of the formulation |
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Definition
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Term
| In Aspirin Tablets USP, not to be less than ___ of the labeled amount dissolves in ___ minutes |
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Definition
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Term
| Potassium Iodide Tablets USP, not less than ___ of the labeled amount in 15 minutes |
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Definition
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