Term
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Definition
stem cells can produce entire human being
-isolated from fertilized egg after fertilization |
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Term
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Definition
| stem cells can produce cells from all 3 embryonic layers, BUT cannot produce entire human being |
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Term
| Pluripotent stem cells isolated from? |
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Definition
| Blastocyst (embryo 5 days after fertilization) AKA embryonic stem cells |
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Definition
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| what type of stem cell is a zygote |
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Definition
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Term
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Definition
produce closely related cell types
-depend on tissue/organ of origin
-adult stem cells
-neural stem cells (brain) --> neurons, astrocytes, oligodendrocytes
-hematopoetic stem cells (bone marrow) -> white and rbc/platelets |
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Term
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Definition
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Term
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Definition
produce only single cell type
AKA committed progenitor cells
-self-renew and therefore = stem cells |
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Term
| committed progenitor cells |
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Definition
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Term
| Therapeutic applications of stem cells |
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Definition
Neurogenerative diseases
(lou gehrigs, Multiple sclerosis, parkinsons, alzheimers, sandhoffdisease)
spinal cord injuries/stroke
burns
heart disease
arthritis/rheumatoid arthritis
hemophilia
diabetes mellitus |
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Term
| Induced pluripotent stem cells iPS |
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Definition
use reprogramming factors to induce a adult cell to become a stem cell
indtroduce ectopic expression of 4 genes (transcription factors) |
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Term
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Definition
genetically matched to patient
cell therapy
treat genetic disorders (replace mutant gene with normal copy in iPS cell |
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Term
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Definition
neural stem cells
mesenchymal stem cells
hepatic stem cells
epidermal stem cells
follicular stem cells
hematopoetic stem cells |
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Term
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Definition
differentiates into
hair follicles and epidermis |
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