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Dr Hickman's handouts Exam 3
Hydrophilic colloids; Amphiphilic colloids; Ointment bases (non-medicated)
19
Pharmacology
Professional
04/07/2011

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Term
Hydrophilic Colloids Classification
Definition
1. Plant hydrocolloids
2. Animal hydrocolloids
3. Modified plant derivatives
4. Inorganic clays
5. Synthetic hydrocolloids
Term
Plant hydrocolloids
(hydrophylic)
Definition
1. Acacia (neg charged, most often used)
2. Tragacanth (neg charged, 10 times more viscous than acacia)
3. Algins (neg charged, derivatives of alginic acid - from seaweeds)
Term
Animal hydrocolloids
(hydrophilic)
Definition
1. Gelatin
2. Pharmagel-A (+ charged) and B (- charged)
3. Egg yolk
4. Casein (milk)
Term
Modified plant derivatives
(hydrophilic colloids)
Definition
cellulose derivatives
Term
Inorganic clays
(hydrophilic colloids)
Definition
1. Bentonite (neg charge, basic pH)
2. Veegum (neg charge, basic pH)
3. Silicates (in his lecture): neg charge, basic pH
Term
Synthetic hydrocolloids: neg charge compd
(hydrophilic colloids)
Definition
Carbopol-934 (Carboxy-vinyl polymer)
Term
Is pharmagel A compatible with acacia?
Definition
No, because pharmagel A is positive charged while acacia is negative charged. Pharmagel B is compatible with acacia
Term
Amphiphilic colloids
(association colloids)
Definition
1. Span (non-ionic, lipophilic)
2. Tweens (non-ionic, hydrophilic)
3. Brijs (~span)
4. Myrjs (~tween)
5. PEG derivatives (~span)
6. Glyceryl derivatives (~span)
7. Propylene glycol derivatives (~span)
8. Sulfates (~span but neg charge e.g. Sodium Lauryl Sulfate)
9. Quaternary ammonium derivatives (~tween but pos charge)
Term
Some commercial non-medicated ointment bases
Definition
1. Hydrocarbon (oleaginous) base
2. Absorption bases
3. Emulsion bases w/o
4. Emulsion bases o/w
5. Water soluble bases
6. Silicone bases
Term
Example of hydrocarbon (oleaginous base)?
Definition
Plastibase
Term
Example of absorption bases?
Definition
1. Almacone
2. Eucerin
3. Aquaphor
4. Plastibase-hydrophilic
5. Polysorb
6. Nivea cream
7. Lanolor
8. Hydrotex
Term
Example of emulsion bases w/o?
Definition
1. Hydrocream
2. Eucerin
3. Nivea cream
Term
Example of emulsion bases o/w?
Definition
1. Velachol
2. Almay
3. Cetaphil
4. Dermabase
5. Dermovan
6. Neobase
7. Unibase
8. Phorsix
Term
Example of water soluble bases?
Definition
Polybase
Term
Example of silicone bases?
Definition
1. Convicone
2. Domicone
3. Silicone
4. Kerodex
Term
Quaternary Ammoxium derivatives (pos charge)
Definition
hydrophilic (~tween) but pos charge
4 R grps and 1 grp has to be C18 to have HLB balance
Emulsified property but used as antibacterial agent e.g. benzyl chronium chloride
Chelating agents: chelate with neg grp like soap
Term
Are all plant hydrocolloids negatively charged?
Definition
Yes, plant (carbohydrate) colloids such as acacia, tragacanth, and algins are negatively charged.
Term
Do inorganic clays need preservative?
Definition
INORGANIC clays are negative charge (basic pH) so do not need preservative
Term
Is carbopol-934 (carboxy-vinyl polymer) natural or synthetic
Definition
It is a synthetic hydrocolloid. It is similar to CMC with neg charge. It has COOH group. CMC - Carboxy Methylcellulose
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