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Dosage Forms II- Exam 1
Pharmaceutical Calculations
87
Science
Professional
01/08/2009

Additional Science Flashcards

 


 

Cards

Term

 

 

 

ac

Definition

 

 

 

before meals

Term

 

 

 

bid

Definition

 

 

 

twice a day

Term

 

 

 

_

c

Definition

 

 

 

with

Term

 

 

 

cap

Definition

 

 

 

capsule

Term

 

 

 

DAW

Definition

 

 

 

dispense as written

Term

 

 

 

D/C

Definition

 

 

 

discontinue

Term

 

 

 

g (or sometimes "gm")

Definition

 

 

 

gram

Term

 

 

 

gr

Definition

 

 

 

grain

Term

 

 

 

gt or gtt

Definition

 

 

 

drop

Term

 

 

 

hs

Definition

 

 

 

at bedtime

Term

 

 

 

IM

Definition

 

 

 

intramuscular

Term

 

 

 

IV

Definition

 

 

 

intravenously

Term

 

 

 

L

Definition

 

 

 

liter

Term

 

 

 

mcg

Definition

 

 

 

microgram

Term

 

 

 

mEq

Definition

 

 

 

milliequivalent

Term

 

 

 

mL

Definition

 

 

 

milliliter

Term

 

 

 

NKA

Definition

 

 

 

no known allergy

Term

 

 

 

NKDA

Definition

 

 

 

no known drug allergy

Term

 

 

 

npo

Definition

 

 

 

nothing by mouth

Term

 

 

 

pc

Definition

 

 

 

after meals

Term

 

 

 

po

Definition

 

 

 

by mouth

Term

 

 

 

prn

Definition

 

 

 

as needed

Term

 

 

 

q

Definition

 

 

 

every

Term

 

 

 

qh

Definition

 

 

 

every hour

Term

 

 

 

q2h

Definition

 

 

 

every 2 hours

Term

 

 

 

qid

Definition

 

 

 

four times a day

Term

 

 

 

qs

Definition

 

 

 

a sufficient quantity

Term

 

 

 

stat

Definition

 

 

 

immediately

Term

 

 

 

tab

Definition

 

 

 

tablet

Term

 

 

 

tid

Definition

 

 

 

three times daily

Term

 

 

 

ud

Definition

 

 

 

as directed

Term

 

 

 

wk

Definition

 

 

 

week

Term

 

 

 

The Metric System is derived

from what units?

Definition

The International System of Units (SI) - the official system for weights and measures as stated in the U. S. Pharmacopeia-National Formulary

SI base units
NameSymbolQuantity
metremlength
kilogramkgmass
secondstime
ampereAelectric current
kelvinKthermodynamic temperature
candelacdluminous intensity
molemolamount of substance

Term

 

 

 

What is the Apothecary

system of measurement?

Definition

 

The traditional system of pharmacy, largely of historical significance, but components of the system are occasionally found on prescriptions.

Term

 

 

 

The Apothecary system bases its fluid measurements on what units?

Definition

Minims ()

Fluidrachms (fʒ or [image])*

Fluidounces (f℥ or ℥)*

Pints (pt)

Quarts (qt)

 

* When it is obvious that a liquid will be measured, the f can be deleted.

Term

 

 

 

The Apothecary system bases its weight measurements

on what units?

Definition

 

Grains (gr)

Scruples (℈)

Drachms (ʒ)

Ounces (℥)

Term

 

 

 

What is the Avoirdupois system?

Definition

 

 

 

A common system of commerce, using ounces and pounds.  This system and the metric system are both used in the U. S. in purchasing and selling goods.

Term

 

 

 

What is the Common or Household system of measurement?

Definition

 

 

The system that a patient would use at home with household items, such as teaspoons, tablespoons, cups, ounces, and pounds.

Term

Length conversion:

 

 

1 inch = ? cm

Definition

 

 

 

2.54 cm

Term

Volume conversion:

 

 

1 pint = ? mL = ? fluidounces

Definition

 

 

 

473* mL = 16 fluidounces

 

 

 

* Rounding to 480 mL is OK

Term

Volume conversion:

 

 

1 fluid ounce = ? mL

 

Definition

 

 

 

29.6* mL

 

 

 

Rounding to 30 mL is OK

Term

Volume conversion:

 

1 fluid dram = ? mL

= ? teaspoonfuls

Definition

 

 

 

5 mL (considered 1 teaspoonful)

Term

Volume conversion:

 

 

1 Tablespoonful = ? mL

Definition

 

 

 

15 mL

Term

Volume conversion:

 

 

2 cups = ? pint = ? mL

Definition

 

 

 

1 pint = 473 mL

Term

Volume conversion:

 

 

8 pints = ? gallon(s)

Definition

 

 

 

1 gallon

Term

Weight Conversion:

 

 

1 kg = ? lb

Definition

 

 

 

2.2 lb

Term

Weight Conversion:

 

 

1 oz. = ? g

Definition

 

 

 

28.4 g

 

 

 

Term

Weight Conversion:

 

 

1 grain = ? mg

Definition

 

 

 

65 mg

Term

 

 

What is the meaning of "w/v"?

Definition

Percent weight-in-volume

 

The number of g of substance in 100 mL of solution or other liquid preparation.

Term

 

 

 

What is the meaning of "v/v"?

Definition

Percent volume-in-volume.

 

The number of mL of a substance in 100 mL of solution or other liquid preparation.

Term

 

 

 

What is the meaning of "w/w"?

Definition

Percent weight-in-weight.

 

The number of g of a substance in 100 g of preparation.

Term

 

 

What is the meaning of "mg %"?

Definition

 

 

The number of mg in 100 mL or 100 g of the preparation.

Term

 

 

What is the specific

gravity of Ethanol?

Definition

 

 

 

0.8 g/mL

Term

 

What is the specific

gravity of Water?

Definition

 

 

1 g/mL

 

 

Term

 

 

What is the specific

gravity of Propylene Glycol?

Definition

 

 

1 g/mL

Term

 

 

What is the specific

gravity of Glycerin?

Definition

 

 

1.25 g/mL

Term

Ratio Strength of 1:10,000

 

What does this mean for

a solid in a liquid?

Definition

 

 

1 g solute/constituent in 10,000 mL

of solution or liquid preparation

Term

Ratio Strength of 1:10,000

 

What does this mean for

a liquid in a liquid?

Definition

 

1 mL of constituent in 10,000 mL

of solution or liquid preparation

Term

 

 

Ratio Strength of 1:10,000

 

What does this mean for

a solid in a solid?

Definition

 

 

1 g of constituent in

10,000 g of mixture

Term

 

 

What is a solubility ratio?

Definition

 

 

The maximum amount of solute that can be dissolved in a given amount of solvent. 

 

Usually given as a range of

solvent volumes (mL)needed to

dissolve 1 part (g) of drug.

Term

 

 

What is a unit?

Definition

A term used to quantify a product in terms of its potency.  It is a function of its activity compared to the activity of reference standard as determined in a bioassay.  For USP grade products, the reference standard is outlined in the USP (which generally conform to international standards, i. e., I. U.)

Term

 

 

od

Definition

 

 

right eye

Term

 

 

os

Definition

 

 

left eye

Term

 

 

What is density?

Definition

 

 

Mass per unit volume

 

Usually expressed as g/cc or g/mL

Term

 

 

What is specific gravity?

Definition

 

 

The ratio of the weight of a substance to the weight of and equal volume of substance chosen as a standard (measured under controlled conditions).

Term

 

 

What are osmoles?

Definition

 

 

Number of osmotically

active molecules

Term

 

 

What are equivalents?

Definition

 

 

The number of charges

Term

 

 

What are moles and millimoles, in terms of weight?

Definition

 

 

Mole = molecular weight of a substance in grams

 

Millimole = molecular weight of a substance in milligrams

Term

 

 

Blood serum and tears contain the physiological equivalent of how many mOsm/L?

Definition

 

 

284

Term

 

 

Among what types of products is tonicity a significant concern?

Definition

 

 

parenterals, opthalmics, and intranasal products

Term

 

 

If a solution is hypertonic,

what can it lead to?

Definition

 

 

Phlebitis

Term

 

 

For nonelectrolytes, such as dextrose, 1 mmol = ? mOsmol?

Definition

 

 

1

Term

 

 

For electrolytes, the number of osmotically active particles in solution depend on the degree of dissociation, so:

 

1 mmol of NaCl = ? mOsmol?

1 mmol of CaCl2 = ? mOsmol?

 

 

Definition

 

 

NaCl = 2 mOsmol

CaCl2 = 3 mOsmol

Term

 

 

The osmolarity of a solution is mOsmol per ?

Definition

 

 

Liter of solution

Term

 

 

When the osmotic nature of a solution is reported as osmolality, it is in units of mOsmol per ?

Definition

 

 

kg of solvent

Term

 

 

For dilute solutions, are values of osmolarity and osmolality nearly the same?

Definition

 

 

Yes. 

As solutions become more concentrated, deviations from ideality occur and the values begin to diverge.

Term

 

 

What do E-values express?

Definition

As sodium chloride equivalents, they express the amount of NaCl equivalent in osmolarity to 1 gram of a drug.  The values consider contributions of the drug's MW, the number of solute particles produced, and the degree of dissociation of the particles.

Term

 

What is a balance's sensitivity?

Definition

 

 

The smallest weight that will cause a perceptible movement of the balance, shown by the balance's indicator scale.

Term

 

 

What is the sensitivity requirement (or maximum potential error)?

Definition

A measure of a balance's sensitivity and is defined in the USP as "the maximum change in load that will cause a specified change, one subdivision on the index plate, in the position of rest of the indicating element or elements of the balance"

Term

Approximate concentrations of electrolytes in plasma:

 

Cation          mEq/L

  Na            ?  

  K+               ?  

 Ca2+                 

Mg2+                ?

  

Definition

 

Cation          mEq/L

  Na            140  

  K+               4  

 Ca2+                 

Mg2+                2

Term

Approximate concentrations of electrolytes in plasma:

 

Anion          mEq/L

   Cl                  ?  

  HCO3-               ?  

 Protein-                 

HPO42-, HPO4-      ?

 SO42-                      ?

Organic acids     ?

 

Definition

Anion          mEq/L

   Cl                  102  

  HCO3-               26  

 Protein-                 16 

HPO42-, HPO4-      2

 SO42-                      1

Organic acids     4

Term

 

 

What is the maximum allowable weighing error for prescription compounding?

Definition

 

 

 

5%

 

Once the SR is known, one can calculate the minimum weighable quantity (MWQ) for a given prescription balance with a maximum of 5% error. 

 

Ex.:  6mg SR/5% error * 100% = 120 mg MWQ

 

Below 120 mg, do an aliquot.

Term

 

 

What are the two most

common approaches to

calculating drug doses?

Definition

 

 

Body weight

and

Body surface area

Term

 

 

For IV drips, what are some classifications (rates) for macrodrips?

Definition

 

 

10 drops/cc

12 drops/cc

15 drops/cc

Term

 

 

For IV drips, what is the drip rate for a microdrip?

Definition

 

 

60 drops/cc

Term

 

 

For an electronic infusion pump (IV) what is the typical range of delivery?

Definition

 

 

1-999 mL/hr

Term

 

 

How can rates of delivery

of IV fluid be prescribed?

Definition

 

 

mL/hr

mL/min

drops/min

mg/min

 

or as total time of

administration

of the fluid

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