HSV1 - oral (some genital) lesions, keratoconjunctivitis

HSV2 - genital (and some oral) lesions

VZV (HHV-3) - chickenpox, zoster, shingles

EBV (HHV-4) - mononucleosis, Burkitt's lymphoma

CMV (HHV-5) - infection in immunosuppressed patients, especially transplant recipients; congenital defects

HHV-6- Roseola (exanthem subitum)

HHV-7-clinically insignificant (included only to complete family)

HHV-8 - Kaposi's sarcoma-associated herpesvirus (KSHV)

Adenovirus

Envelope?

DNA structure

Disease

No envelope present

Double-stranded, linear DNA

Febrile pharyngitis-sore throat

Pneumonia

Conjunctivitis ("pink eye," watery)

Parvovirus

Envelope?

Structure

Diseases

No Envelope

 Single-stranded linear, negative sense DNA

B19 virus - aplastic sickle-cell crises

"slapped cheeks" rash in erythema infectiosum (fifth disease), RBC destruction in fetus -> hydrops fetalis/death

No envelope

Double-stranded, circular DNA

HPV-warts, CIN, cervical cancer

No envelope

double-stranded circular DNA

JC virus - progressive multifocal leukoencephalopathy (PML) in HIV

Enveloped

Double-stranded,linear (largest DNA virus)

Smallpox

Vaccinia - cowpox ("milkmaid's blisters")

Molluscum contagiosum (wrestlers)