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3' to 5' exonuclease activity |
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Stimulates exonuclease activity |
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Binds Holoenzyme to ssDNA |
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Interacts with SSB - allows for removal of Dna G (Primace) |
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Binds Dna Polymerase to Dna Strand |
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Dimerizes Core; Activates Dna B helicase activity |
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DNA Strand with 9bp region and 13 bp region. 9bp region wraps around Dna A complex to initiate replication fork |
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Single Strand Binding Proteins. Bind at replication fork (both strands) to prevent re-annealing of the template DNA (PROK) Requires ATP |
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Helicase Enzyme responsible for growing replication fork (PROK) |
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Part of DNA B-C complex which loads helicase onto replication fork. Dissociates after loading DNA B. (PROK) |
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Primase Enzyme responsible for synthesizing 11(+/-) 1 nt RNA primer which initiates synthesis for DNA Polymerase. Interacts with DNA B (connection is not fully understood) (PROK) |
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Synthesizes leading strand DNA as well as Okazaki fragment DNA. (PROK) |
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Synthesizes DNA to connect Okazaki Fragments. Removes RNA primers on lagging strand. (PROK) |
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viral encoded helicas (EUK) |
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Replication protein A - SSB equivalent. (EUK) |
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Replication Protein C - Clamp loader. (EUK) |
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Proliferating Cell Nuclear Antigen (trimer which acts as a sliding clamp) (EUK) |
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Primary leading strand polymerase. (EUK) |
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Primary Polymerace for leading strand in YEAST (EUK) |
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