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Diuretics
na
7
Pharmacology
Professional
05/02/2010
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Term
furosemide
 Definition
-loop diuretic
-inhibits tubular reabsorption of Na by inhibiting a Na, K, 2Cl cotransporter located in the apical membrane of the tubule cell
-also fosters increased excretion of calcium into the urine’
-acts on the thick ascending loop of Henle
-most efficacious natriuretic
Term
thiazides
 Definition

-commonly administered as a drug of first choice for the treatment of primary hypertension

-can inhibit tubular reabsorption of Na by inhibiting a Na/Cl cotransporter

-causes a reduction in peripheral vascular resistance when used chronically

-may cause HYPOKALEMIA

-increase in excretion of water and NaCl, increase excretion of K, decreased excretion of Ca
Term
chlorthalidone
 Definition
-diuretic
-thiazide-like
Term
triamterene
 Definition
-acts as an inhibitor of sodium channels (ENaC inhibitor)
-will increase in excretion of water and NaCl and decrease excretion of K and H
Term
eplerenone
 Definition
-aldosterone antagonist
-can cause hyperkalemia
Term
adenosine
 Definition
-when administered IV, causes transient heart block in the AV node
-antiarrhythmic agent
-used quickly by the body and has an extremely short plasma half life
Term
acetazolamide
 Definition
-diuretic drug that targets carbonic anhydrase
-will cause alkalinization of the urine, thus it can influence tubular reabsorption of certain drugs
-could be used to facilitate excretion of a weak organic acid
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