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Diuretics Chapter 42
Diuretics
28
Pharmacology
Undergraduate 1
01/29/2011

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Term
Diuretics aer used for two main purposes...
Definition

1. Decrease hypertension (lower blood pressure)

2. Decrease edema (peripheral and pulmonary) in heart failure and renal or liver disorders.

Term
Diuretics increase urine flow
Definition
Diuresis, by inhibiting sodium and water reabsorption from the kidney tubules
Term
Diuretic effect depends on
Definition
the drug reaching the kidneys and its concentration in the renal tubules
Term
Diuretics have an antihypertensive effect because they
Definition
promote sodium and water loss by blocking sodium and chloride reabsorption, causing decrease in fluid volume and lowering BP.
Term
Diuretics that promote potassium excretion
Definition
potassium-wasting diuretics
Term
potassium sparing diuretics
Definition
promote potassium retention
Term
diuretics effective in removing water and sodium
Definition

thiazide and thiazide like

loop or high ceiling

osmotic

carbonic anhydrase inhibitor

potassium sparing

Term
most frequent diuretics prescribed for hypertension and edema associated with HF
Definition
thiazide, loop or high ceiling, potassium sparing
Term
all diuretics
Definition
are potassium wasting, except the potassium sparing group
Term

Thiazides

short acting

Definition

chlorothiazide (diuril)

hydrochlorothiazide (hydroDIURIL, HCTZ)

Term

diuretic thiazide

intermediate acting

Definition

bedroflumethaizide (naturetin)

benzthiazide (Exna)

hydroflumethiazide (saluron, diucardin)

 

Term
long acting thiazides
Definition

methyclothiazide (aquatensen, enduron)

polythiazide (renese-R)

trichlormethiazide (diurese metahydrin, naqua)

Term
thiazide like diuretics
Definition

chlorthalidone (hygroton)

indapamide (lozol)

metalazone (Zaroxolyn)

quinethazone (hydromox)

Term
people who take diuretics should be monitored closely for
Definition
hypercalcemia- diuretics promote calcium reabsorption
Term
Side effects of thiaziedes include
Definition
electrolyte embalances (hyperglycemia, hyperuricemia, and hyperlipidemia
Term
Diuretics should be given
Definition
in the morning, to avoid nocturia
Term
osmotic diuretics
Definition

decrease intercranial pressure.

used with nephrotoxic chemotherapy drugs for faster excretion

Term
potassium sparing
Definition

spironalactone (aldactone)

used in patients with severe CHF

Term
first-line choice for many patients
Definition

thiazides

loop

osmotic

potassium sparing

Term
DEFINE DIURESIS:
Definition
↑ URINE OUTPUT
Term
DEFINE HYPERKALEMIA
Definition
↑ POTASSIUM LEVEL
Term
DEFINE NATRIURESIS
Definition
SODIUM LOSS IN THE URINE
Term
OLIGURIA
Definition
MARKED ↓ IN URINE OUTPUT
Term
DEFIUNE OSMOLALITY
Definition
CONCENTRATION
Term
WHAT EFFECTS DOES ALOE HAVE?
Definition
↓ SERUM POTASSIUM LEVELS, THEREBY CAUSING HYPOKALEMIA WHEN TAKEN WITH A POTASSIUM WASTING THAZIDE
Term
UVA URSI MAY...
Definition
↑ THE EFFECTS OF DIURETICS CAUSING ELECTROLYTE IMBALANCE
Term
GINKGO MAY....
Definition
↑ B/P WHEN TAKEN WITH THIAZIDES
Term
LICORICE CAN...
Definition
↑ POTASSIUM LOSS , LEADING TO HYPOKALEMIA
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