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Diseases of the GI Tract
Test 4
144
Microbiology
Undergraduate 3
04/28/2013

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Term
If left undisturbed, normal biota biofilm contains _______ bacteria that can damage soft tissues and bones called __________ surrounding the teeth.
Definition
anaerobic. peridontium.
Term
Introduction of carbs to the oral cavity can result in breakdown of what?
Definition
dentition.
Term
What is the causative agent of dental caries?
Definition
Streptococcus mutans and sucrose
Term
What is the most common infectuous disease of humans?
Definition
Dental caries.
Term
Are dental caries endogenous or exogenous?
Definition
Endogenous
Term
Who is more succeptible to dental caries?
Definition
Young
Term
How does dental caries attach to tooth enamel?
Definition
Pili
Term
What are the 2 chemicals created from the metabolism of Sucrose in the mouth?
Definition
Glucan and lactic acid.
Term
What does glucan do?
Definition
Key component of plaque. Makes plaque impenetrable to saliva.
Term
What does lactic acid do?
Definition
Breaks down the tooth's enamel.
Term
What happens once the tooth's enamel is compromised?
Definition
S. Mutans along with other oral bacteria causes an infection of the underlying tissue
Term
What is the causative agent of Periodontal disease?
Definition
Poryphyromonas gingivalis.
Term
How does porphyromonas gingivalis cause disease?
Definition
Releases enzymes which causes a weakening of the gingival tissue and surrounding bone along with inflammation.
Term
What are the symptoms of Periodontal Disease?
Definition
Most asymptomatic but can cause sensitive gums, tooth discoloration and loosening/loss of the tooth
Term
What is the mumps?
Definition
An acute viral infection of the parotid glands (Parotitis)
Term
What is the causative agent of the mumps?
Definition
Paramyxovirus family
Term
Is the mumps an RNA or DNA virus?
Definition
RNA
Term
What is the incubation period of the mumps?
Definition
2-3 weeks
Term
What are the symptoms of the mumps?
Definition
Swelling of the parotid gland and face pain.
Term
What other organs does the mumps target?
Definition
Parotid glands, testes, ovaries, meninges, pancreas
Term
How is the mumps contracted?
Definition
Direct contact or by inhaled respiratory droplets
Term
What is gastritis/gastric ulcers?
Definition
Inflammation of the stomach associated with the production of gastric ulcers
Term
What is the causative agent of gastritis/gastric ulcers?
Definition
Helicobacter pylori
acidophilic urease positive
Term
What is gastritis?
Definition
Sharp burning pain emanating from the abdomen
Term
Ulcers are?
Definition
Lesions in the mucosa of the stomach
Term
Where is a duodenal ulcer?
Definition
Uppermost portion of the small intestine.
Term
What are the symptoms of a duodenal ulcer?
Definition
Bloody stool, vomiting...
Term
What are up to a third of all diarrheal illness contracted by?
Definition
Contaminated food
Term
Most cases are self-______ and do not require treatement.
Definition
limiting
Term
What is the causative agent in salmonellosis?
Definition
Salmonella enteritidis
Term
How is salmonella contracted?
Definition
Consumption of raw or undercooked food products
Term
What are the symptoms of salmonella?
Definition
Fever, cramps, diarrhea.
Term
How long does salmonella last?
Definition
4-7 days without treatment.
Term
What is the causative agent of typhoid fever?
Definition
Salmonella typhi.
Term
How is typhoid fever contracted?
Definition
Fecal-oral route
Term
What organ does typhoid fever target?
Definition
Small intestine
Term
What are the symptoms of typhoid fever
Definition
HIgh fever, malaise, stomach pains, loss of appetite and in some cases a rash.
Term
If untreated, how long can typhoid fever last? If treated?
Definition
Weeks-months. 2-3 days.
Term
Where does typhoid fever reside?
Definition
The gallbladder of asymptomatic hosts.
Term
Who is Typhoid Mary?
Definition
Infected 53 people and never contracted it herself.
Term
What is the causative agent of shigellosis?
Definition
Shigella dysenteriae, flexneri, and sonnei
Term
What does shegellosis target?
Definition
The large intestine
Term
How is shigellosis contract?
Definition
Fecal-oral route
Term
How does Shigellosis attack?
Definition
Potent toxin known as Shiga toxin that breaks down the intestinal lining
Term
What are the symptoms of shigellosis?
Definition
Fever, inflammation of gut wall, diarrhea containing blood and mucus.
Term
What is the most virulent strain of E.Coli?
Definition
O157:H7
Term
What does enterohemorrhagic E. Coli cause?
Definition
Mild gastroenteritis with fever to bloody diarrhea.
Term
About ____ of patients develop hemolytic uremic syndrome which damages the kidneys so they fail.
Definition
10
Term
Can enterohemorrhagic e. coli cause neurological symptoms such as what?
Definition
Yes. Blindness, seizure, stroke
Term
What does enterotoxigenic e.coli cause?
Definition
Inflammatory disease of the large intestine
Term
What does enteropathogenic e.coli cause?
Definition
Linked to a wasting form of infantile diarrhea
Term
What does enteroaggregative e.coli cause?
Definition
Chronic diarrhea in young children and in AIDS patients.
Term
What is Campylobacteriosis?
Definition
the leading bacterial form of diarrhea in the US
Term
What causes campylobacteriosis?
Definition
Campylobacter jejuni
Term
How is campylobacteriosis contracted?
Definition
Fecal-oral route
Term
What is the rare complication that C. Jejuni can result in and what is it?
Definition
Guillian-Barre syndrome. General paralysis.
Term
What does C.Diff cause? Where is it common?
Definition
Pseudomembranous colitis. Hospitals.
Term
How does C.Diff attack and what does it target?
Definition
Superinfects the large intestine when drugs have disrupted the normal flora. Produces two toxins A and B that cause necrosis in the wall of the intestines.
Term
What is the causative agent of cholera?
Definition
Vibrio cholera
Term
How is cholera contracted?
Definition
Fecal-oral transmission. Binds to cells in small intestine. Produces powerful cholera toxin that results in the loss of 20L of fluid daily.
Term
What are the symptoms of cholera?
Definition
Rice water stool
Term
If untreated, can cause death in ______ and has a ____% mortality rate
Definition
48 hours/55%
Term
What is the causative agent of cryptosporidium?
Definition
Cryptosporidium parvum
Term
How is cryptosporidium contracted?
Definition
Ingested as cysts usually when agricultrual run off has contaminated a water supply
Term
Cryptosporidium is common in _________ and was not identified as a threat to human until the _____ __________.
Definition
cattle/aids epidemic
Term
What are the symptoms of cryptosporidium?
Definition
Fever, loss of appetite, nausea, cramps, watery diarrhea
Term
What causes most cases of viral gastroenteritis in infants and children?
Definition
Rotavirus
Term
How do the effects of the rotavirus vary?
Definition
With age, nutritional state, general health, and living conditions. Generally pass in a week but can last weeks in some cases.
Term
Are vaccines available for rotavirus? If so, explain.
Definition
Yes. Have to be administered at 2 & 4 or 2,4 & 6 months to be effective.
Term
What is responsible for half of all the cases of viral gastroenteritis in the US?
Definition
Noroviruses
Term
How is Norovirus contracted?
Definition
Fecal-oral route or from eating contaminated shell fish.
Term
How long do symptoms last?
Definition
12-60 hours without treatment
Term
What is Giardiasis causative agent?
Definition
Giardia Lamblia
Term
What is the most common waterborne illness in the US?
Definition
Giardiasis.
Term
What are specific symptoms to Giardiasis? How long do they last?
Definition
-floating stool
-flatulence

can last several weeks.
Term
How is Giardiasis contracted?
Definition
Fecal-oral usually via contaminated drinking water.
Term
Symptomatic and asymptomatic patients of Giardiasis can become _____-_____ carriers.
Definition
long-term
Term
What is hepatitis?
Definition
Inflammation of the liver
Term
How is Hep A spread?
Definition
Fecal-oral transmission
Term
Are most cases asymptomatic or symptomatic? Mild or severe symptoms?
Definition
Asymptomatic. Mild.
Term
With Hep. A is jaundice common and is it linked to liver cancer?
Definition
No and no
Term
Is a vaccine available for Hep A?
Definition
Yes.
Term
How is Hep B transmitted?
Definition
Via blood or body fluids with a small infectious dose. Sharing razors and tooth brushes
Term
What are the symptoms of Hep B?
Definition
Anorexia, jaundice, tender/swollen liver, coke-colored urine, clay-colored stool.
Term
Can Hep B lead to cirrhosis and liver cancer?
Definition
Yes
Term
Is a vaccine available for Hep B?
Definition
YES
Term
Hepatitis C is considered a _______ epidemic?
Definition
silent
Term
How is Hep C transmitted?
Definition
Blood and body fluids
Term
What are the symptoms of Hep C?
Definition
Jaundice, coke urine and clay colored stool
Term
Can Hep C lead to cirrhosis and liver cancer?
Definition
Yes
Term
Is there a vaccine for Hep C?
Definition
No
Term
Who can Hep D only infect?
Definition
People with Hep B
Term
How is Hep D contracted?
Definition
Body fluid and blood
Term
What does Hep D do?
Definition
Magnify the symptoms of Hep B
Term
Is there a vaccine for Hep D?
Definition
No
Term
What is Hep E similar to?
Definition
Hep A.
Term
How is Hep E transmitted?
Definition
Fecal-oral
Term
Is Hep E acute/chronic? Mild/severe?
Definition
Mild chronic
Term
Is Hep E common in US?
Definition
Not yet
Term
Is there a vaccine for Hep E?
Definition
No
Term
How is Hep G transmitted?
Definition
Blood and body fluids
Term
Is Hep G linked to Hep C?
Definition
No, but often seen in those patients with Hep C
Term
About ____% of patients with Hep C have Hep G.
Definition
20
Term
Is there a vaccine for Hep G?
Definition
No
Term
What is the treatment for Hep A?
Definition
No specific treatment. Will often resolve itself spontaneously. Patient should abstain from drugs and alcohol.
Term
What is the treatment for Hep B?
Definition
Acute - Rest along with a high carb/protein diet to repair liver cells.

Chronic - Interferon
Term
What is the treatment for Hep C?
Definition
Interferon and Ribavirin
Term
What are the treatments for Hep D, E, G?
Definition
None.
Term
What is taenia saginatus associated with?
Definition
Contaminated beef
Term
What is taenia solium associated with?
Definition
Contaminated pork
Term
What is diphyllobothrium latum associated with?
Definition
Contaminated fish
Term
What is dipylidium canium associated with?
Definition
Contaminated dog or cat.
Term
What happens if a tapeworm goes unnoticed?
Definition
Obstruct the GI tract
Term
What is a specific symptom of a tapeworm infection?
Definition
Eggs or larva in the stool.
Term
What does treatment of a tapeworm target? What should be done to reinsure you do not reinfect yourself?
Definition
Adult tapeworms. Hand washing.
Term
Where do liver flukes reside?
Definition
The bile duct of the liver.
Term
How is a fluke contracted?
Definition
Eating raw or undercooked fish.
Term
What are two chinese liver flukes?
Definition
Opisthorchis sinensis and Clonorchis sinensis
Term
What is an intestinal fluke?
Definition
Fasciola buski
Term
Where does fasciola buski target?
Definition
Large intestinal parasite acquired by ingesting the larval form of the worm on unwashed plants.
Term
What are symptoms of fasciola buski infection?
Definition
Malabsorption and toxemia
Term
What is schistsoma mansoni?
Definition
A blood fluke
Term
Where does schistsoma mansoni reside?
Definition
Veins of the abdominal cavity
Term
How is schistisoma mansoni infect?
Definition
Contact with the larva which penetrates the hair follicle.
Term
What are the symptoms of a schistosoma mansoni infection?
Definition
Rash, itchy skin, fever, cough, chills, muscle aches.
Term
How are the eggs of S. Mansoni expelled from the body?
Definition
Feces or urine
Term
What is a paragonimus westermani?
Definition
Lung fluke
Term
How is P. Westermani transmitted?
Definition
Infected shellfish. The larva enter the blood stream and move up to the lungs.
Term
After reproducing in the lungs, P. Westermani eggs are coughed up into the GI tract and leave how?
Definition
Feces
Term
What is a enterobius vermicularis?
Definition
Pinworm. Nematode. Most common helminthe infection in the US.
Term
How is E. Vermicularis transmitted?
Definition
Fecal-oral occasionally airborne.
Term
How do female E. Vermicularis lay eggs?
Definition
Emerge from the anus that causes itchiness of the anus which is the most common symptom of the infection.
Term
What is trichuris truchura?
Definition
Whipworm. Nematode.
Term
Where it T. Trichura common?
Definition
Tropical climates where sanitation is poor
Term
How is T. Trichura transmitted?
Definition
Fecal-oral route.
Term
What are the symptoms of T. Trichuria?
Definition
Bloody diarrhea and deficiency anemia. Profusion of the rectum with severe infections
Term
What is necator americanus & ancylostoma duodenale?
Definition
Hookworms. Nematodes.
Term
How does N. Americanus and A. Duodenale get transmitted?
Definition
Burrows through skin of people walking barefoot on contaminated group and move into the bloodstream and enter the lung tissue. Entry site is red and itchy.
Term
What are the symptoms of a N. Americanus and A. Duodenale infection?
Definition
Cough and bloody sputum.
Term
The larva of N. Americanus and A. Duodenale move up the bronchi and then where?
Definition
Are swallowed then take host in the small intestine which results in nausea, vomiting, diarrhea, and abdominal pain.
Term
What does Trichinella Sprialis cause?
Definition
Trichinosis, Trichiniasis, Trichinellosis.
Term
What is T. Sprialis associated with?
Definition
Undercooked meats such as pork
Term
How is T. Spiralis contracted
Definition
Ingested cysts burst open and grow into adult worms that cause the production of more cysts
Term
Once contracted, where do T. Spiralis worms move? What about severe infections?
Definition
Bloodstream and into the muscle tissue resulting in pain when breathing and chewing. Can invade neural and lung tissue.
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