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Digestive System & Metabolism
Midterm 2: Digestive System & Metabolism
67
Physiology
Undergraduate 2
07/30/2013

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Term
Your digestive organs are suspended within this cavity by double sheets of serosal membreane called (a) and are found in the (b) cavity (which lies within the abdominal cavity.)
Definition
A) mesenteries
B) peritoneal
Term
What are the 4 layers of a hollow organ, from deep to superficial
Definition
1)mucosa
2)submucosa
3)muscularis externa
4)serosa
Term
The 2 main movements generated by GI smooth muscles are called:
Definition
peristalsis and segmentation
Term
The major digestive enzyme made by the salivary gland is:
Definition
salivary amylase
Term
Name another salivary enzyme
Definition
lysozyme
Term
Which of the salivary glands produces the most saliva?
Definition
submandibular
Term
What types of muscles line the esophagus?
Definition
smooth and skeletal
Term
A side-effect of some antihistamines includes upset stomach (while other types of antihistamines are primarily used to treat acid reflux). Why might antihistamines affect the GI tract?
Definition
Histamines trigger HCl secretion form the Chief cells in the stomach, which lowers pH. A low pH is necessary for full activation of pepsin. Antihistamines there for lower stomach acid production and activation of pepsin, which can disrupt/slow digestion of food.
Term
What is the dental formula, by type?
Definition
incisors-2, canines-1, premolars-2, molars-3
Term
What are the names of the three phases of gastric activity, and a major hallmark of each?
Definition
1) cephalic- thinking of food & salivation; stomach responds to sight, smell, taste, or thought of food
2)gastric-increases HCl secretion; food activates gastric activity, the stomach begins to secrete digestive enzymes and juices
3)inhibits gastric, promotes pancreatic/intestinal secretions;chyme reach the duodenum, intiating the process of nutrient absorption in the small intestine
Term
The (a) sphincter regulates the movement of chyme into the duodenum.
Definition
pyloric
Term
Name the 3 regions of the small intestine, beginning right after the stomach:
Definition
duodenum,jejunum, ileum
Term
Fat-laden chyme pass through the stomach at what speed?
Definition
slower
Term
What percentage of nutrient absorption happens in the small intestines?
Definition
90%
Term
The brush border lies on the apical surface of intestinal epithelial cells, and is composed of microscopic (a)(sub-cellular structures). These structures main functions is to increase (b). The epithelial cells are, in turn arranged into fingerlike projections called (c). Inside each one of these are small blood vessels and a lymphatic ducts known as (d).
Definition
a- microvilli
b- surface area
c- villi
d- lacteal
Term
Exocrine pancreas: Acinar cells release (a) juices that mix with the chyme exiting the stomach. The net result of this mixture is that the pH inside the duodenum is roughly (b).
Definition
basic, neutral
Term
Exocrine pancreas: name 3 digestive enzymes that the pancreas secretes into the duodenum
Definition
trypsin, chymotrypsin, carboxypeptidase, pancreatic amylase, pancreatic nucleases, pancreatic lipases
Term
Endocrine pancreas: The pancreas secretes the horomone (a) into the blood when blood glucose is high, and the hormone (b) into the blood when blood glucose is low.
Definition
a)insulin
b)glucagon
Term
Exocrine pancreas: Insulin is made by ? cells in the pancreas.
Definition
beta islet
Term
A hepaic triad is composed of a/an ?, ?, and ?
Definition
bilary duct, hepatic portal vein, hepatic artery
Term
Blood enters the liver from these blood vessels:
Definition
hepatic portal vein, hepatic artery
Term
What do we mean by the emulsification of fat, and why is it important to the digestive process?
Definition
Mechanical breakdown of fat droplets into smaller droplets increases the surface area for better digestion of fat by lipases; Emulsification of fat is a process in which large droplets of fat are broken down into small droplets of fat (with the help of bile salts). Because fat globules are rather large and would take a long time for the lipases to break them down, emulsification makes them smaller, allowing them to be broken down by lipase at a faster rate.
Term
What might happen to a patient who loses liver function? (focus on the liver's main digestive functions)
Definition
The patient wouldn't be able to digest fats or fat soluble vitamins, break down toxins within the body, and decrease its ability to regulate red blood cells in the body.
Term
What the main function and site of production for secretin?
Definition
increases exocrine pancreatic secretions; duodenum
Term
What the main function and site of production for cholycystokinin?
Definition
Increases bile release; duodenum
Term
What the main function and site of production for gastric inhibitory peptide?
Definition
Increases insulin release; duodenum
Term
What the main function and site of production for vasoactive intestinal peptide?
Definition
increases blood flow to gut;duodenum
Term
What the main function and site of production for gastrin?
Definition
Increases stomach acid production; stomach
Term
What the main function and site of production for enterocrinin?
Definition
Increases mucus production; duodenum
Term
The ileocecal valve connects the (a) and the (b)
Definition
ileum and cecum
Term
Which of the anal sphincters is skeletal muscle & under conscious control?
Definition
external
Term
What molecules are absorbed in the colon?
Definition
H2O, bile salts, vitamins (K, biotin, B5)
Term
Describe how fat absorbed into the body--be sure to include relevant anatomy and molecular terminology.
Definition
Fat is digested in the small intestines (with the aid of bile salts from the liver/gall bladder), absorbed in the small intestines and packed up into chylomicrons which can then be absorbed by the lacteals.
Term
What is the difference between trans-fats and healthy mono-unsaturated fats?
Definition
Trans-fats contain trans carbon-carbon double bonds that cause them to stack easily on each other and increase their melting point.  Mono-unsaturated fats have cis carbon-carbon double bonds that cause them to be more kinked and lest stackable, keeping them at a lower melting point.
Term
What is the difference between saturated and unsaturated fats?
Definition
Saturated fats have no carbon-carbon double bonds (thus they are completely saturated with hydrogen atoms.)  They stack very densely on top of each other, and they have higher melting points than unsaturated fats.  Unsaturated fats have at least 1 carbon-carbon double bond in their chain.
Term
Why are trans-fats unhealthy?
Definition
Trans-fats can easily stack on top of each other because of their trans carbon-carbon double bonds.  This increases their melting point and causes them to be solid at room temperature and in the body.  Because they are mostly solid in the body, they can easily create blockages in the blood vessels that can lead to atherosclerosis.
Term
Why are omega-3 fatty acids (or other mono-unsaturated fatty acids) considered healthy?
Definition
Omega-3 fatty acids can not be synthesized in the body and are essential.  They can also help reduce triglyceride levels in the blood.  Mono-unsaturated fats also reamain liquid at body temperature, and can reduce artherosclerosis.
Term
How many Carbon atoms are in Pyruvate?
Definition
3
Term
How many carbon atoms are in Acetate (acetyl-CoA)?
Definition
2
Term
What is the difference between good fats and HDL's?
Definition
Good fats are larger molecules that we eat that are also hydrophobic.  HDLs are good cholesterol; they are also macromolecules in the body that high density lipoproteins that consists of tiny droplets of fat coated with proteins and phospholipids.
Term
Name the 2 differences between HDLs and LDLs.
Definition

HDL (high density lipoproteins) contain more protein than fat and are sent from the peripheral tissue/target organs to the liver.

 

LDL (low density lipoproteins) conatin more fat than protein and are sent from the liver to the peripheral tissues.

Term
When the nitrogen atom is removed from amino-acids, this usually produces the poisonous molecule (a) which must then be converted into (b) in the liver, which can be excreted in urine.
Definition

(a) ammonia

(b) urea

Term
Define deamination-
Definition
Removal of N's from amino acids
Term
Define glycogenesis-
Definition
making new glycogen molecules
Term
Define glycolysis-
Definition
Breaking down glucose
Term
Define gluconeogenesis-
Definition
Making new glucose molecules
Term
Define glycogenolysis-
Definition
Breaking down glycogen to form glucose
Term
Define lipolysis-
Definition
Breaking down fat
Term
Define Lipogenesis-
Definition
Making new lipid molecules
Term
How can excess dietary protein be converted into fat?
Definition
Excess protein can be deaminated (amino acid is broken down) and converted to keto acids.  The keto acids are then converted into glycerol and free fatty acids to form trigylcerides.
Term
What happens to the body when Insulin is released into the bloodstream?
Definition
Glucose is removed from the bloodstream, and is absorbed by most cells in the body.  It is either used or stored as a type of macromolecule.
Term
What happens to adipocytes when insulin is released in the bloodstream?
Definition
Absorbs glucose, turns it into triglycerides
Term
What happens to muscle fibers when insuling is released in the bloodstream?
Definition
Absorbs glucose (and amino acids), converts it into glycogen
Term
What happens to liver cells when insulin is released in the bloodstream?
Definition
Absorbs glucose, converts it into glycogen
Term
What happens to the CNS neurons when insulin is released in the bloodstream?
Definition
No change to glucose usage, may inhibit appetite
Term
What cells make Insulin?
Definition
B-islet cells of the pancreas
Term
When does the pancreas release Insulin into the bloodstream?
Definition
Whe blood glucose levels are high/elevated
Term
Type I Diabetes is also known as:
Definition
Juveline Diabetes
Term
Type I diabetes is Insulin dependent or Insulin resistant?
Definition
Insulin dependent
Term
Blood glucose levels in Type I Diabetes is usually
Definition
high
Term
Blood Insulin levels in Type I Diabetes is usually
Definition
low
Term
The number of insulin receptors in Type I Diabetes is usually
Definition
normal
Term
Type II Diabetes is also known as
Definition
Adult-Onset Diabetes
Term
Type II Diabetes is insulin-dependent or insulin-resistant?
Definition
insulin-resistant
Term
Blood glucose levels on type II diabetics is usually..
Definition
high
Term
Blood insulin levels in type II diabetics is usually ..
Definition
high
Term
The number of insulin recpetors in type II diabetics is usually...
Definition
low
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