Term
| What is the leading cause of end stage renal failure in the US? |
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Definition
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Term
| What type of nodules are seen in the LM of a diabetic nephropathy patient? |
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Definition
| Kimmelsteiel Wilson nodules |
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Term
| What is the hemodynamic mechanism that contributes to the diabetic nephropathy? |
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Definition
| vasodilation of the afferent arteriole, which raises the glomerular hydrostatic pressure |
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Term
| What is the metabolic mechanism that contributes to the diabetic nephropathy? |
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Definition
glycoslation
increase in PKC
which increases mesangial matrix and cells |
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Term
| What are the clinical complications of diabetes? (6) |
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Definition
nephropathy
neuropathy
peripheral vascular disease
retinopathy
dyslipidemia
HTN |
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Term
| What type of diabetes is diabetic nepropathy more common in? |
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Definition
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Term
| What typical presentation of a diabetic patient will lower the chances of you needing to do a renal biopsy? |
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Definition
long standing DM
proteinuria
benign urine sediment
renal insufficiency |
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Term
| Which stage of diabetes do you see the beginning of the nephropathy? Why? |
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Definition
| stage 3 b/c onset of microalbuminuria |
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Term
| What is true of the GFR in the beginning stages of diabetes? |
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Definition
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Term
| Which stage of diabetes is the clinical stage for diabetic nephropathy? |
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Definition
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Term
| What is the general time frame for progressing through the stages of diabetes toward end stage renal failure? |
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Definition
stage 1 weeks to months
stage 2 after 2 years
stage 3 10-15 years
stage 4 5-10 after stage 3
stage 5 7 years after stage 4 |
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Term
| How often are type I diabetic screened for microalbuminuria? |
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Definition
| after 5 years of disease and every year after |
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Term
| How often are type II diabetics screened for microalbuminuria? |
|
Definition
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Term
What BP is the goal for HTN treatment in diabetic patients and renal disease patients in general?
What is it for the normal population? |
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Definition
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