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Diabetes
objectives
58
Nursing
Undergraduate 1
11/09/2011

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Term
Counter Regulatory Hormones
Definition
Hormones that work against the action of insulin, raising blood glucose levels in response to hypoglycemia (low blood sugar).
Term
Dawn phenomenon
Definition
Very high blood glucose in the early morning due to the release of certain hormones in the middle of the night.
Term
Diabetic ketoacidosis
Definition
a problem that occurs in people with diabetes. It occurs when the body cannot use sugar (glucose) as a fuel source because there is no insulin or not enough insulin. Fat is used for fuel instead.
Byproducts of fat breakdown, called ketones, build up in the body.
Term
Diabetic nephropathy
Definition
kidney disease or damage that occurs in people with diabetes. Characterized by high protein levels in the urine.
Term
Diabetic peripheral neuropathy
Definition
nerve damage caused by diabetes.
Term
Diabetic retinopathy is
Definition
damage to the eye's retina that occurs with long-term diabetes.
Term
Gestational diabetes mellitus
Definition
a condition in which women without previously diagnosed diabetes exhibit high blood glucose levels during pregnancy (especially during third trimester of pregnancy). Affects 3-10% of pregnancies, depending on the population studied.
Term
Glucagon,
Definition
a hormone secreted by the pancreas, raises blood glucose levels. Its effect is opposite that of insulin, which lowers blood glucose levels.
Term
Gluconeogenesis
Definition
a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids.

It is one of the two main mechanisms humans and many other animals use to keep blood glucose levels from dropping too low (hypoglycemia). The other means of maintaining blood glucose levels is through the degradation of glycogen (glycogenolysis).
Term
Glucosuria
Definition
the excretion of glucose into the urine.
Term
DKA
Definition
Diabetic Ketoacidosis
Term
Claudication
Definition
pain in walking
Term
Glycogen is
Definition
a molecule that serves as the secondary long-term energy storage in animal and fungal cells, with the primary energy stores being held in adipose tissue. Glycogen is made primarily by the liver and the muscles, but can also be made by glycogenesis within the brain and stomach
Term
Glycogenolysis
Definition
is the conversion of glycogen polymers to glucose monomers.
Term
Hemoglobin A1c
Definition
Glycated hemoglobin;a form of hemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time.
Term
Hyperosmolar hyperglycemic syndrome
Definition
a complication of type 2 diabetes that involves extremely high blood sugar (glucose) levels without the presence of ketones. Ketones are byproducts of fat breakdown.
Term
hyperglycemia
Definition
Polyphagia - frequent hunger, especially pronounced hunger
Polydipsia - frequent thirst, especially excessive thirst
Polyuria - frequent urination
Blurred vision
Term
hypoglycemia/ss
Definition
Double vision or blurry vision
Fast or pounding heartbeat
Feeling cranky or acting aggressive
Feeling nervous
Headache
Hunger
Shaking or trembling
Term
Hypoglycemic unawareness
Definition
having it without knowing
Term
Impaired fasting glucose
Definition
more commonly known as pre-diabetes refers to a condition in which the fasting blood glucose level is consistently elevated above what is considered normal levels;
Term
Impaired glucose tolerance (IGT) is
Definition
a pre-diabetic state of dysglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality
Term
Insulin is:
Definition
a hormone central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle.
Term
Insulin reaction
Definition
occurs when a person with diabetes becomes confused or even unconscious because of hypoglycemia caused by insulin or oral diabetic medications.
Term
insulin resistance
Definition
tissues in the body – particularly muscle and fat tissues- do not respond appropriately to insulin. In fact, more insulin is needed to elicit the same response from these tissues.
Term
Ketonuria:
Definition
A condition in which abnormally high amounts of ketone bodies (a byproduct of the breakdown of cells) are present in the urine. Ketonuria is a sign seen in diabetes mellitus that is out of control.
Term
Ketone bodies are:
Definition
three water-soluble compounds, acetone, acetoacetic acid, and beta-hydroxybutyric acid, that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain.
Term
Lipoatrophy is:
Definition
the term describing the localized loss of fat tissue. This may occur as a result of subcutanous injections of insulin in the treatment of diabetes,
Term
Lipodystrophy is:
Definition
a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue.
Term
Macrovascular disease is:
Definition
a disease of any large (macro) blood vessels in the body.
Term
Microalbuminuria:
Definition
occurs when the kidney leaks small amounts of albumin into the urine, in other words, when there is an abnormally high permeability for albumin in the renal glomerulus.
Term
Osmotic diuresis is:
Definition
increased urination caused by the presence of certain substances in the small tubes of the kidneys.
Term
pancreatic beta cells:
Definition
Insulin is a peptide hormone composed of 51 amino acids that is synthesized, packaged, and secreted in pancreatic beta cells.
Term
Polydipsia is
Definition
a medical symptom in which the patient displays excessive thirst.
Term
Polyphagia means
Definition
"eating too much".
Term
Somogyi effect
Definition
a rebounding high blood sugar that is a response to low blood sugar. Somogyi showed that excessive insulin makes diabetes unstable,
Term
Type 1 diabetes mellitus
Definition
is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas.
Term
Type 2 diabetes mellitus
Definition
is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency.[2] Diabetes is often initially managed by increasing exercise and dietary modification.
Term
diabetes prevalance:
Definition
25.8 million children and adults in the United States—8.3% of the population—have diabetes.
Diagnosed: 18.8 million people
Undiagnosed: 7.0 million people
Prediabetes: 79 million people*
Term
population at risk, cultural issues, risk factors
Definition
Age 65 years or older, 10.9 million, or 26.9% of all people in this age group have diabetes
13.3% for Mexican Americans
12.6% of non-Hispanic blacks
Term
A glucose tolerance test is
Definition
a medical test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood.
Term
Lispro
Definition
insulin used to treat type 1 and type 2 diabetes. It is a rapid-acting insulin, used to help control the spike in blood sugar that occurs after meals. It is typically used in combination with a long-acting insulin. Insulin lispro can also be used in an insulin pump.
Term
NPH insulin is
Definition
an intermediate-acting insulin given to help control the blood sugar level of those with diabetes.
Term
Lente insulin
Definition
is an insulin with an intermediate duration of action. It has an onset of action 2-4 hours after injection, a peak activity 6-12 hours after injection, and a duration of action of 18 to 26 hours.
Term
Ultralente insulin is
Definition
a long-acting insulin with an onset of action 4-8 hours after injection, a peak effect 10-30 hours after injection, and a duration of action of more than 36 hours.
Term
glargine insulin
Definition
marketed by Sanofi-Aventis under the name Lantus, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes.
Term
Sulfonylureas
Definition
a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas.
Term
Biguanides
Definition
oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment.
Term
Alpha-glucosidase inhibitors are:
Definition
oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar).
Term
Meglitinides,
Definition
aka "Glinides", are a class of drugs used treat diabetes type 2.(Prandin)These drugs should be taken 0-30 minutes prior to eating.
Term
Thiazolidiones
Definition
a drug usually indicated in cases of type II diabetes for decreasing blood sugar.
Term
Microvascular complications
Definition
The organs most sensitive to a reduction in perfusion are the eyes, kidneys and nerves.
Term
Macrovascular disease refers to
Definition
atherosclerosis, or hardening, of the large arteries.
Term
Acute complications
Definition
hyperglycemia, hypoglycemia, ketoacidosis (blood sugar becomes high and the blood becomes abnormally acidic)
Term
HHS
Definition
Hyperosmolar hyperglycemic state; is characterized by hyperglycemia, hyperosmolarity, and dehydration without significant ketoacidosis.
Term
SMBG
Definition
Self-Monitoring of Blood Glucose
Term
pancreas transplant
Definition
the recipient's native pancreas is left in place, and the donated pancreas is attached in a different location. In the event of rejection of the new pancreas which would quickly cause life-threatening diabetes, the recipient could not survive without the native pancreas still in place. Patients with pancreatic cancer are not eligible for valuable pancreatic transplantations, since the condition has a very high mortality rate and the disease, being highly malignant, could and probably would soon return.
Term
prediabetes
Definition
(impaired glucose tolerance and impaired fasting glucose)
Term
Differentiate between the classification of prediabetes and diabetes
Definition
Pre-diabetes means your blood sugar levels are higher than normal, yet not high enough to be categorized as type 2 diabetes. Levels above 100 and up to 125 mg/dl indicate impaired fasting glucose, or pre-diabetes.
If levels are 126 mg/dl and above on two separate testing dates, the diagnosis would be diabetes.
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