Shared Flashcard Set

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Diabetes Background
Diabetes Background
39
Pharmacology
Professional
09/12/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
High blood glucose indicates?
Definition
That the glucose cannot get into the cell or cannot be properly stored
Term
Insuline moves glucose into...?
Definition
muscle and other tissue cells
Term

Type I diabetes?

Type II diabetes?

Definition

Type I diabetes: complete lack of insulin

 

Type II diabetes: combination of insulin resistance and decreased insulin production.

Term
Hyperglycemia leads to?
Definition
micro and macrovascular health complications
Term
Which is autoimmune, type I or type II?
Definition

Type I diabetes. Patient's antibodies destroy the pancreatic beta cells which produce insulin. There is no correlation with obesity.

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Term
Those with type I diabetes may present with?
Definition
ketoacidosis (DKA), which is life - threatening condition
Term
Type I diabetes usually presents in younger or older?
Definition
younger, thinner patients
Term
The primary cause of type II diabetes?
Definition

lifestyle: increase in weight, low level of physical activity and poor nutritional intake

Term
Which drugs are most likely to increase blood sugar?
Definition

Corticosteroids (e.g. prednisone)

Protease Inhibitors (e.g. ritonavir)

Term
Which atypical antipsychotics raise blood glucose the most?
Definition
Olanzapine (Zyprexa)
Term
Which transplant drug raises blood glucose the most?
Definition

Tacrolimus (Prgraf), a transplant drug, which has a boxed warning for post- transplant diabetes in kidney - transplant patients

Term
Clinical presentation of Type I and Type II diabetes?
Definition

Hyperglycemia, the 3 P's (polyuria, plyphagia and polydipsia) and weight loss are usually present in type 1 patients. Type 2 patients have hyperglycemia, but may not have the 3 P's.

Term
Criteria for diagnosis of diabetes?
Definition

(1) signs and symptoms of diabetes (3 Ps) AND a random plasma glucose ≥ 200 mg/dL OR


(2) FPG ≥ 126 mg/dL OR


(3) 2- hr plasma glucose of ≥ 200 mg/dL during a 75 g oral glucose tolerance test (OGTT), OR


(4) HbA1C ≥ 6.5%

Term
What are microvascular complications?
Definition

Retinopathy (most common)

Nephropathy (can lead to renal dysfunction and ESRD)

Peripheral Neuropathy

Autonomic neuropathy (erectile dysfunction)

Term
Macrovascular complications associated with diabetes?
Definition

Macrovascular = larg vessel disease

 

Coronary artery disease (MI, HF, HTN)

Cerebrovascular Disese (Stroke, TIA)

Peripheral Artery Disease

Term
How does diabetic ketoacidosis come about?
Definition

Not enough insulin, and the body breaks down fat to make energy. The breakdown of fats causes the concentration of ketones in the blood to increase. DKA can lead to coma, and if not treated quickly, can result in death

Term
What other conditions, aside from kiabetes, can cuase diabetic ketoacidosis?
Definition

Acute illness such as an infection, pancreatitis, myocardial infarction and stroke

Term
Diabetic ketoacidosis symptoms?
Definition

Hyperglycemia

The 3 P's

Blurred Vision

Metabolic Acidosis (fruity breath, dyspnes)

Dehydration (dry mouth, excessive thirst, poor skin turgor, fatigue)

Term
Diabetic Ketoacidosis lab abnormalities?
Definition

Glucose > 300 mg/dL

Ketones Present in urine and blood

pH < 7.2

Bicarb < 15 mEq/L

WBC 15 - 40 cells/mm3

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Term
Treatment for diabetic ketoacidosis
Definition

IV fluids and insuline. Closely monitoring and replacing electrolytes. This typically involves using NS, followed by 1/2 NS, and corrected potassium to bring the level > 3.5 mEq.L

 

Term
Treatment for diabetic acidosis and its effect on potassium and DVT risk?
Definition

Potassium: even if high initally, should be expected to drop as insulin is administered. It may be necessary to replace potassium as the insulin drives the potassium into the cells (intracellular)

 

DVT: May be required to administer an anticoagulant to prevent DVT - the hospitalized patient should be considered at high risk for clotting

Term
Why is A1C a better indicator of treatment than blood glucose?
Definition

Meter tests the blood at that given moment, the hemoglobin A1C (or A1C) measures the average blood glucose level over the past few months

Term
How often is A1C measured?
Definition

Quarterly if not controlled and semiannually if controlled

 

Term
The American Diabetes Association (ADA) goal for A1C is?
Definition

< 7%, and states that < 6% may be better, especially for type 1 patients

Term
The American Associated of Clinical Endocrinologists (AACE) guidelines for A1C are a goal of?
Definition
< 6.5 %
Term
Describe the estimated Average Glucose (eAG) test?
Definition

The eAG is a newer test that is becomming more popular. It may be easier for patients to understand because the value is like the blood glucose number they are used to seeing when they measure their BS.

 

[image]

 

Just note the number corrispoding to an A1C of 7

Term
What is the goal blood pressure for diabetic patients?
Definition
< 130/80 mmHg
Term
What should be chosen for inital diabetic treatment?
Definition
ACEIs or ARBs to help reduce the development of nephropathy
Term
When is the only time an ARB is indicated over an ACEI?
Definition

When a type II patient has hypertension, macroalbuminuria and chronic renal insufficiency, defined as SCr > 1.5

Term
If a patient is still not at BP goal with ACEI or ARB therapy, then what should be added?
Definition

A thiazide diuretic (if CrCL > 30 min/min) or a loop diuretic (if CrCL < 30 ml/min)

Term
Any protein in the urine indicates?
Definition

Renal disease and requires strict blood glucose and blood pressure control.

 

Microalbuminemia: 30 - 300 mg

 

Macroalbuminemia: > 300 mg and indicates worsening renal disease

Term
How often should diabetics examine their feet?
Definition

Daily! By patient, caregiver, every visit to the physician, and annually by a podiatrist

Term
How often should a diabetic have an eye exam?
Definition

Annually, but may be done less frequently (every 2-3 years) if past eye exam(s) were normal

Term
What vaccines should diabetic patients receive?
Definition

All patients with diabetes should get the fall influenza immunization, and a pneumococcal vaccine once (repeat if > 65 years old or if it was longer than 5 years since 1st immunization)

Term
Consider aspirin therapy for primary prevention in those with?
Definition

increased CV risk (10 - year risk > 10%).  This includes mean > 50 years of age and woman > 60 years of age with at least one additional major risk factor.

 

 

Term
The dose of aspirin?
Definition

Uusally 81 mg EC.

 

If patient has an aspirin allergy, clopidogrel 75 mg daily can be used as an alternative

 

Term

 

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Definition

Statment. Not a question.

 

Term
When should insulin initially be started?
Definition

Consider insulin as initial therapy (with lifestyle modification) in patients with fasting glucose greater than 250 mg/dL or A1C > 10% or those with ketouria or symptoms of hyperglycemia

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Term
Where doe the AACE and ADA treatment guidelines differ?
Definition

They agree with the recommendation of metformin as initial therapy (unless insulin is rquired). They differ in 2nd line treatment options.

 

ADA prefers the older drugs (sulfonylrueas) and the AACE prefers to avoid these due to risk of hypoglycemia and weight gain.

 

AACE recommends metformin first. Pioglitazone, incretin mimetics (such as exenatide), and DPP-4 inhibitors are favored as second line therapies.

 

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