Term
| In general, where does recombination usually occur? |
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Definition
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Term
| During what type of cell division does recombination often occur and what is it called? |
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Definition
| During meiosis have crossing over |
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Term
| What is equal vs unequal crossing over? |
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Definition
| Equal crossing over is like exchange of the same material. Unequal crossing over is unequal sharing of DNA=bad mutations. |
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Term
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Definition
| remove bad gene and replace it with a new one. |
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Term
| What is illegitimate recombination? |
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Definition
| Gene is inserted in the wrong place. (pretty common in gene therapy) |
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Term
| What are the three main problems with gene therapy? |
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Definition
| The size of the gene you have to put in, gene silencing by the cell itself (so it wouldn't work), insertional mutagenesis...you cause other mutations/problems/oncogenesis by inserting in the wrong place. Also, viral vectors can causes immune response and death. |
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Term
| What is the point where DNA's interact called? |
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Definition
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Term
| How does hemophilia A (factor IIIV deficiency) happen? |
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Definition
| There is an inverted repeat of the factor IIIV gene. It likes to bind to itself by complementarity. If you get crossing over, gene oriented the wrong way= bad news bears. |
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