Term
| how would you classify p.foliaceus? |
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Definition
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Term
| subcorneal acantholytic blistering disease |
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Definition
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Term
what are other disorder causes the same split?
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Definition
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Term
| Staphylococcal scalded skin syndrome |
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Definition
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Term
| which inflammatory cells are *** in p. foliaceus? |
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Definition
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Term
eosinophils are characteristic in p. foliaceus
Neutrophils can also be seen |
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Definition
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Term
which other condition can p. foliaceus mimic?
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Definition
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Term
bullous impetigo - this can occur if p. foliaceus get impetiginized
IMPETIGINIZED CRUST DOES NOT R/O P. FOLIACEUS |
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Definition
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Term
What is the underlying cause of p. foliaceus?
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Definition
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Term
| autoantibodies directed against desmoglein 1 (160 kD) |
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Definition
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Term
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Definition
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Term
desmoglein 1 is an intercellular (transmembrane) keratinocyte adhesion glycoprotein in association with desmosomes
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Definition
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Term
| what is the difference between desmoglein and desmoplakin? |
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Definition
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Term
desmoplakin is intracellular
desmoglein is transmembrane
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Definition
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Term
| describe the DIF of p. foliaceus |
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Definition
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Term
DIF of p. foliaceus:
considered diagnostic. INTERCELLUAR immunofluorescence of IgG and C3 deposits confined to the UPPER HALF of the epidermis
described as a NET-LIKE pattern |
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Definition
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Term
| where does the split occur in p. foliaceus? |
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Definition
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Term
| split occurs in the granular layer in p. foliaceus |
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Definition
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Term
| what is pemphigus erythematosus? |
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Definition
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Term
p. erythematosus is a condition that the immunohistologic findings are between p. foliaceus and lupus erythematosus:
1. ANA antibody
2. DIF shows intercellular deposition AND "lupus band" along basement membrane |
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Definition
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Term
| summarize the key features of p. foliaceus |
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Definition
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Term
key features of p. foliaceus:
- subcorneal split
- acantholysis
- dyskeratosis in the granular layer
- DIF net-like pattern of IgG and C3 between keratinocytes of the upper epidermis
- eosinophils around BVs and in epidermis
- spongiosis
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Definition
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Term
| what conditions cause spongiosis with epidermal eosinophils? |
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Definition
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Term
eosinophilic spongiosis = HAAPPIEES
- Herpes gestationis
- Arthopod bite reaction
- Allergic contact
- Pemphigus foliaceus
- Pemphigoid
- Incontinentia pigmenti
- Erythema toxicum (spongiosis ajacent to hair follicle)
- EBA
- Scabies
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Definition
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Term
| what is another name for Grover's disease? |
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Definition
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Term
transient acantholytic dyskeratosis (TAD)
persistent acantholytic dermatosis (PAD)
TAD and PAD are groovey!! |
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Definition
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Term
| what is TAD or Grover's disease infamous for? |
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Definition
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Term
TAD can mimic Darier's disease and Hailey-Hailey and pemphigus!
All of these histo features can be seen in the SAME specimen!! |
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Definition
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Term
| since Grover's disease is sooo GROOVEY, how can you pin the diagnosis down? |
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Definition
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Term
grover's disease can be diagnosed by:
- clinical appearance: focal lesions
- histo: many patterns are seen in the same biopsy clues you in that it's groovey Grover!!
- eosinophils: if present, r/o Darier's
- DIF: negative cf. to pemphigus
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Definition
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Term
| how would you define Grover's disease? |
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Definition
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Term
| Grover's disease is an acquired, pruritic, self-limiting, acantholytic disease of unknown etiology of middle aged to elderly |
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Definition
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Term
| where on the body does Grover's disease typically occur? |
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Definition
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