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Dermatology Chapter 5
chapter 5 derm
45
Anatomy
Graduate
06/02/2011

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Term
quick list of epidermal growths:
Definition
Wart
Corn
Seborrheic Keratosis
Skin Tag
Molluscum Contagiosum
Actinic Keratosis
Squamous Cell Carcinoma
Basal Cell Carcinoma


Uncommon epidermal growths:
- merkel cell carcinoma
- nevus sebaceous
- trichoepithelioma
Term
epidermal growths occur due to proliferation of ___ or __ cells.
Definition
keratinocytes
basal cells
Term
With epidermal growths ___ is usually prominent. ___ , __, or __ suggest cancer.
Definition
- scaling
- bleeding, crusting, itching
Term
warts are caused by multiple ___ __. Treatments are nonspecific and destructive.
Definition
papillomavirus types
Term
warts are more common in __ __and __ __. Immunosuppressed are more prone to severe breakouts.
Definition
- healthy children and young adults
Term
types of warts (5):
Definition
- common wart
- flat wart
- plantar wart
- condyloma acuminatum
- filiform
Term
scaling verrucous papules with interrupted skin lines and black puncta:
Definition
wart
Term
warts do/do not interrupt skin lines?
Definition
DO interrupt skin lines
Term
With warts the ___ is thickened with overlying ___. Vacuolated ___ are present in the ___ cell layer.
Definition
- epidermis
- hyperkeratosis
- keratinocytes
- granular
Term
___ is used a treatment for warts but it is ___ so do NOT apply it to extensive lesions or give it to __ women.
Definition
- Podophyllin
- toxic
- NOT for pregnant women
Term
Podophyllin used to treat warts is a potent __ and ___ agent with caustic action. It is derived from ___ and roots of Podophyllum pellatum (mandrake, may apple). This directly affects epithelial cell ___, causing degeneration and arrest of mitosis.
Definition
- cytotoxic and keratolytic
- derived from rhizomes
- metabolism
Term
podophyllin is ___ __.
Definition
category x
Term
Corns are caused by ___ or ___. Corns do/do not interrupt skin lines.
Definition
- friction or pressure
- do NOT

Corns will persist until friction/pressure is relieved.
Term
Corns do NOT interrupt skin lines. Warts DO interrupt skin lines.
Definition
you're such a wart, you interrupted me!
Term
Corns have a __ center and ___ skin lines.
Definition
clear
intact
Term
Corn treatment:
Definition
- relieve friction and pressure
- paring down with a scalpel
- soften with salicylic acid plaster
- surgical correction of deformity
Term
Seborrheic keratosis is common in adults/kids?
Definition
adults
Term
Tan-dark brown, well demarcated "stuck-on appearance":
Definition
Seborrheic keratosis

WHEN IN DOUBT, BIOPSY TO RULE OUT MELANOMA
Term
Therapy for seborrheic keratosis?
Definition
- cryotherapy with liquid nitrogen
- curettage
- shave biopsy or excision
Term
What is the course of seborrheic keratosis?
Definition
people tend to get more of them
Term
soft pedunculated papules:
Definition
skin tag
Term
Therapy for skin tag:
Definition
- no therapy necessary
- large/necrotic ones should go to pathology
- snip off with scissors
- cryotherapy with liquid nitrogen
Term
___ ___ is caused by the pox virus. This appears as umbilicated smooth papules. Use destructive treatment.
Definition
Molluscum Contagiousum
Term
Molluscum Contagiousum therapy:
Definition
- Cryotherpay with liquid nitrogen
- Salicylic acid
- Cantharidin
- Curettage
Term
Actinic keratosis (AK) is ___ and can be prevented with ___ ___.
Definition
- pre-cancerous
- sun protection

(Light skin and sun exposure may lead to actinic keratosis)
Term
Rough, scaling, ill marginated lesion that is often easier felt than seen?
Definition
Actinic keratosis (AK)
Term
___ AKs should be biopsied to rule out cancer.
Definition
Indurated
Term
Actinic keratosis can develop into __ __ __.
Definition
squamous cell carcinoma
Term
Actinic keratosis therapy:
Definition
- sunscreen, hat, etc.
- cryotherapy with liquid nitrogen
- 5-Fluorouracil
- Diclofenac 3% bid x 3 months
- Imiquimod 5% cream
Term
Squamous cell Carcinoma is a malignancy of the ___ and has the potential to ___. SCC in situ is aka ___ ___.
Definition
- keratinocytes
- metastasize
- Bowen's disease
Term
SCC arising in an AK has ___ metastatic potential.
Definition
low
Term
The second most common skin cancer that often occurs on the head, neck, or arms:
Definition
Squamous Cell Carcinoma

(chronic ulcers should be biopsied to exclude malignancy)
Term
__ and __ SCC is more likely to metastasize.
Definition
Lip and oral
Term
Therapy for SCC:
Definition
- excision
- curettage and electrodesiccation
- Moh's micrographic surgery
- Radiation
- Cryotherapy
Term
____ are neoplasms of the epithelium that are biologically benign, but histologically resemble a SCC.
Definition
Keratoacanthomas (KA)
Term
Nodule with a central keratin filled crater. These grow rapidly, but most involute within 6 months.
Definition
Keratoacanthoma (KA)
Term
Basal cell carcinoma is a malignancy of the __ __ __ that rarely metastasizes but can be locally destructive. List the 4 types of BCC.
Definition
- epidermal basal cells

4 types:
- nodular
- pigmented
- superficial
- scaring
Term
The most common skin cancer, it rarely metastasizes:
Definition
Basal Cell Carcinoma
Term
Pearly pink papule:
Definition
Basal cell carcinoma
Term
Therapy for BCC:
Definition
- excision
- curettage and electrodessication
- Moh's micrographic surgery
- radiation
- cryotherapy
- topical 5-FU or Imiquimod
Term
Merkel cell carinoma is very rare, but more ___ than melanoma. It has a __ rate of local recurrence and metastsis. This usually presents as a solitary __ on the __ or __ of elderly persons.
Definition
- deadly
- high
- solitary nodule
- head or neck
Term
A __ __ of __ is a hemartoma of sebaceous glands and other cutaneous structures that appears at birth and becomes ___. Tumors and/or __ can develop. These usually occur along a ___ __. Perform excision, but not until after __ b/c can come back bigger and worse if excised too early.
Definition
- Nevus Sebaceous of Jadasson
- warty
- BCC
- hair line
- puberty

side note: this is uncommon
Term
___ is a benign tumor of the hair follicle. This usually occurs on the __ and presents as single or multiple __ flesh colored papules.
Definition
- Trichoepithelioma
- face
- firm
Term
Multiple trichoepitheliomas may result from an autosomal ___ condition known as ___ ___ disease.
Definition
- dominant
- Brook-Spiegler
Term
warts are caused by:
Definition
multiple papillomavirus types
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