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Derm
Chapter 11
58
Court Reporting
Not Applicable
06/07/2011

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Term
Inflammatory Papules Important Points:
Prominent ___
May see ___ secondary to scratching
Papules ___ in Lichen Planus and KP
Definition
itching
crusting
scaling
Term
Scabies Caused by...
Definition
itch mite Sarcoptes scabiei var. hominis
Term
Scabies Papules result from ____
Definition
hypersensitivity

"delayed from burrowing"
Term
Scabies Incidence
More common in (3)
Definition
NH, HIV, Down’s
Term
Scabies History
Very ___
Incubation time ___ month
Get pet history with recurrent cases – canine scabies
Definition
1
pruritic
Term
Scabies Physical Examination...
Definition
Finger webs, wrists, elbows, axillae, girdle area, feet, and male genitalia
Palmoplantar vesicles in infants
2-5 mm burrow
Delicate, white, serpiginous, superficial thread-like line
Tiny black speck representing adult mite
Nodular form in long standing disease
Burrow located in superficial epidermis
Term
[image]
Definition
scabies
Term
Scabies DOC?

Other Treatments:
Definition
Elimite

Lindane – risk of neurotoxicity
Systemic ivermectin 0.1-0.2mg/kg as single dose
Wash clothes and linens in hot water
Itching may occur up to 1 month after treatment
Term

Scabies Course and complications:

Definition

Secondary bacterial infection

Norwegian scabies

     - Widespread crusted version that may not itch

     - Seen in immunocompromised patients

Term
Scabies Pathogenesis:
Definition
Female burrows under skin Lays 2-3 eggs daily for 30 days
Human – human transmission most common
Inoculation to itching -> 1 month
Term
_______ Definition
Sting – bees, wasps, fire ants
Bite – mosquitoes, fleas, flies, bedbugs, lice
Definition
insect bite reactions
Term
Insect Bite Reactions Incidence
Anaphylaxis in 0.5-1.5% of stings
____ are leading cause of allergy in the US
____ leading cause in the south
Definition
Yellowjackets
Fireants
Term
Insect Bite Reaction History
Definition
Other household member may or may not be affected
Term
Insect Bite Reactions Physical Examination
___ – immediate hive with central punctum
___ will leave behind a stinger
____ – necrosis
____– favor the legs
____ – breakfast lunch and dinner pattern
Definition
Sting
Honeybee
Brown recluse
Chiggers
Flea bites
Term
Insect Bite Differential diagnosis (2)
Definition
Fiberglass
Mucha-Habermann disease
-> Necrotic papules and vesicles
-> More generalized and symmetric
Term
Insect bite Biopsy
Definition
wedge-shaped superficial and deep eosinophilic infiltrate
Term
Insect Bite Therapy (2)
Definition
Prevention – DEET
Topical steroids
Term
Insect Bite Course and complications
Definition
Anaphylaxis
Desensitization therapy
Injectible epinephrine (Ana-Kit or EpiPen)
Persistent reaction – erythema migrans of Lyme disease
Term
Insect Bite Pathogenesis
Definition
Histamine, acetylcholine, and other vasoactive chemicals
Term
Lichen Planus Definition – _____
Definition
idiopathic
Term
Lichen Planus Incidence
Definition
4.4 per 1000
Women > men
Term
Lichen Planus History
Definition
Itching
Pain on mucosal surfaces
Term
Lichen Planus Physical Examination
Definition
Purple, polygonal, flat-topped papule Wickham’s striae – fine reticulated pattern of white dots and lines Wrists, ankles, palms, soles, genitalia, mucosal surfaces
Term
Lichen Planus Differential diagnosis (lots)
Definition
PV, PR, DLE, secondary syphilis
Lichenoid Drug eruption – thiazides, phenothiazines, gold, quinidine, quinicrine, and chloriquine
Term
Lichen Planus Biopsy
Definition
Saw-toothed of rete
Band like infiltrate of lymphocytes in superficial dermis
Term
[image]
Definition
Lichen Planus
Term
Lichen Planus Treatment
Definition
Topical steroids
Acitretin for oral or severe cases
Term
Lichen Planus Course and complications
Definition
Self-limiting
2/3 of patients have resolution within 1 year
Mucous membranes portends worse prognosis
Usually a 7 year disease.
Hard to treat on genitals.
Mucus membranes hard to treat.
Term
Lichen Planus Pathogenesis
Definition
Cause unknown
Immune factors play a role
Immunoglogulins at DE junction
LP like eruptions in bone marrow transplant patients
Term
Definition: Occlusion of the sweat duct with extravasation of its contents in surrounding tissue
Definition
miliaria
Term
Miliaria Incidence
Definition
More common in warm humid environments
Term
Miliaria History
Definition
Bedridden patients
Term

Miliaria Physical examination

¡Miliaria ____
úMost common form of miliaria
úMultiple, discrete, red papules
úTrunk
úNot associated with hair follicles
¡Miliaria ______
úSuperficial, non-inflamed vesicles
more common in babies
¡Miliaria ____
úErythematous pustules

Definition

rubra

crystillina

pustulosa

Term
[image]
Definition
miliaria
Term
Miliaria Differential diagnosis (3)
Definition
Contact dermatitis – more pruritic and confluent
Folliculitis
Candidiasis – more beefy red with satellite pustules and papules
Term
Miliaria Therapy
Definition
Cooling measures and air exposure
Topical steroids for itching
Term
Miliaria Pathogenesis
Definition
Miliaria crystallina – obstruction occurs in stratum corneum
Term
Keratosis Pilaris Definition – ...
Definition
keratinized hair follicles
Term
KP Incidence –
Definition
50% of population
Term
KP History
Definition
Not pruritic or painful
Worse in winter and improve with age
Term
KP Physical examination
Definition
Folliclular papules with central horny plug
Bilateral upper arms (most common location), thighs
Term
[image]
Definition
Keratosis Pilaris (KP)
Term

 

¨KP Differential diagnosis (2)
Definition
¡Lichen spinulosis
úAppear suddenly
úAbdomen, extensor surfaces
úRemit after 1-2 years
¡Lichen nitidus
úFlat topped and smoother
Term
¨KP Therapy
Definition
¡20% urea
¡6% salicylic acid
¡12% ammonium lactate
¡Tretinoin or tazarotene cream
Term
Keratosis pilaris is a Very common Autosomal ____ condition
Definition
dominant
Term
Lichen Spinulosis:
___ onset
Happens in ____ and _____ ______
Abdomen, extensor arms, knees, and neck
Remits after 1-2 year
Definition
Sudden
Children and young adults
Term
[image]
Definition
lichen spinulosis
Term
_______ AKA Transient Acantholytic Dermatosis
Definition
Grover’s Disease
Term
Pruritic eruption of truncal, reddish brown, keratotic papules
Definition
Grover's Disease
Term
Grover's Disease Incidence:
Definition
Middle-aged to elderly Caucasian males
Term
Grover's Disease:
Pruritic
Treat with potent topical ___
Disease is NOT ____
Almost always on ___ & ___
Definition
steroids
transient
chest and back
Term
[image]
Definition
Grover's Disease
Term
Minute, flat-topped papules with a shiny appearance
Definition
Lichen Nitidus
Term
Lichen Nitidus affect what parts of body:
Definition
Upper extremities, dorsal hands, genitalia, and trunk
Term
Lichen Nitidus: Biopsy shows a “______” formation of lymphocytic infiltrate surrounded by elongated rete ridges
Resolution within several years
Definition
ball and claw
Term
[image]
Definition
lichen nitidus
Term
Pityriasis lichenoides et varioliformis acuta (PLEVA)
____-____ disease
Recurrent crops of crusted, reddish papules that regress within weeks
Most common in ____
If persistent, condition is known as .....
Rare cases becoming ____
Treatment with topical ____ and oral ___
Definition
Mucha-Haberman
children
pitryiasis lichenoides chronica
CTCL (t cell lymphoma)
steroids
antibiotics (erythromycin)
Term
[image]
Definition
Pleva
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