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Derm Path
n/a
114
Pathology
Professional
03/06/2014

Additional Pathology Flashcards

 


 

Cards

Term
Possible melanocytotic presursor
Definition
dysplastic nevus
Term
histology: 'shouldering', 'melanocyte bridging'
Definition
dysplastic nevus
Term
BRAF mutations
Definition
melanoma
Term
histology: nests and single migrating cells, 'Buckshot pattern'
Definition
melanoma
Term
'stuck on'
Definition
seborrheic keratosis
Term
leser-trelat sign
Definition
seborrheic keratosis
Term
histology: string sign, acanthosis
Definition
seborrheic keratosis
Term
histology: horn pseudocyst
Definition
seborrheic keratosis
Term
p53 mutation
Definition
BOTH SqCC and BCC
Term
velvety hyperpigmented plaque
Definition
acanthosis nigricans
Term
Cowden Syndrome
Definition
trichilemmoma
Term
PTEN
Definition
trichilemmoma
Term
multiple flesh colored papules around nose and mouth
Definition
tichilemomma
Term
'turban tumor'
Definition
cylindroma
Term
apocrine gland tumor
Definition
cylindroma
Term
histology: 'basaloid islands in puzzle pieces', pink cylinders
Definition
cylindroma
Term
assoc with Muir-Torre
Definition
sebaceous adenoma
Term
histology: 'lobules of sebocytes'
Definition
sebaceous adenoma
Term
scaly erythematous patch on sun-damaged skin
Definition
actinic keratosis
Term
precursor of squamous cell carcinoma
Definition
actinic keratosis
Term
histology: basal layer atypia with overlying parakeratosis, epithelial dysplasia
Definition
actinic keratosis
Term
histology: 'flag sign' - alternating parakeratosis and orthokeratosis
Definition
actinic keratosis
Term
risk factor = arsenic exposure
Definition
SqCC
Term
carcinoma with ulcerated center
Definition
SqCC
Term
histology: keratin pearls
Definition
SqCC
Term
histology: neoplasm originating in stratum spinosum and forms 'islands'
Definition
SqCC
Term
SqCC in situ
Definition
Bowen's Disease
Term
HPV-induced SqCC
Definition
Bowenoid Papulosis
Term
histologically cup-shaped neoplasm, variant of SqCC, may resolve spontaneously but are still treated
Definition
keratoacanthoma
Term
poorly differentiated SqCC variant, worse prognosis
Definition
Spindle cell SqCC
Term
aggressive variant of SqCC similar histologically to a verruca
Definition
verrucous carcinoma
Term
PTCH mutation
Definition
BCC
Term
Pearly, pink papule with overlying telangiectasia
Definition
BCC
Term
histology: peripheral palisading nuclei and cleft formation
Definition
BCC
Term
multiple BCC before age 20
Definition
Gorlin Syndrome
Term
dimple sign
Definition
dermatofibroma
Term
histology: tabled rete ridges, collagen trapping, boomerang fibrohistiocytes
Definition
dermatofibroma
Term
large, multinodular lesion common on trunk of young to middle-aged adults
Definition
dermatofibrosarcoma protuberans
Term
histology: 'storiform' (whorled fibroblasts)
Definition
dermatofibrosarcoma protuberans
Term
cutaneous T cell lymphoma
Definition
mycosis fungiodes
Term
histology: atypical CD4+ lymphocyte 'soldiers' along DEJ
Definition
mycosis fungiodes
Term
histology: pautrier's microabscesses
Definition
mycosis fungiodes
Term
histology: atypical CD4+ lymphocytes with kidney bean shaped nuclei called cerebriform nuclei
Definition
mycosis fungiodes
Term
fish scales, AD
Definition
ichthyosis vulgaris
Term
histology: defective desquamitization
Definition
ichthyosis
Term
salmon plaque, well-demarcated, silver scale, extensor surfaces
Definition
psoriasis
Term
Auspitz sign
Definition
psoriasis
Term
histology: wafer-like parakeratosis
Definition
psoriasis
Term
erythema nodosum associated with trauma sites/scars
Definition
sarcoidosis
Term
histology: non-caseating granulomas
Definition
sarcoidosis
Term
ill-defined red nodules often on the anterior shins
Definition
erythema nodosum
Term
histology: subQ fat inflammation
Definition
erythema nodosum
Term
fine whitish lines, having a network arrangement, on the surface of lichen planus papules
Definition
Wickham striae
Term
Pruritic, purple, polygonal, papules / plaques
Definition
lichen planus
Term
dermatosis associated with HCV
Definition
lichen planus
Term
histology: saw-tooth infiltrate, 'band-like' lymphocyte infiltrate below DEJ
Definition
lichen planus
Term
target lesions assoc with infectious cause
Definition
erythema multiforme
Term
painful epidermolytic blisters w/ mucous membrane involvement, >10% body SA
Definition
SJS
Term
SJS >30% of body SA
Definition
TEN
Term
Gottron's papules, heliotrope rash, shawl sign
Definition
dermatomyositis
Term
tense bullae
Definition
bullous pemphigoid
Term
histology: subepidermal blister with eosinophils
Definition
bullous pemphigoid
Term
IF: IgG antibodies to hemidesmosomes, linear IF
Definition
bullous pemphigoid
Term
'Nicholsky sign' - rubbing skin forms blister w/in minutes
Definition
almost always found in TEN and is assoc. with pemphigus vulgaris. It is useful in differentiating PV vs bullous pemphigoid.
Term
histology: suprabasalar clefting = 'tombstoning'
Definition
pemphigus vulgaris
Term
IF: IgG antibodies against desmoglein 3, 'net-like' intraepidermal IF
Definition
pemphigus vulgaris
Term
pruritic papules and vesicles assoc with Celiac dz
Definition
dermatitis herpetiformis
Term
IF: granular IgA deposits
Definition
dermatitis herpetiformis
Term
HPV driven, 'condyloma acuminatum'
Definition
verruca
Term
histology: hyperkeratosis, hypergranulosis, papillomatosis, koilocytes (vacuolated keratinocytes with raisin like nuclei)
Definition
verrucae
Term
viral infection of the skin caused by poxvirus
Definition
molluscum contagiosum
Term
histology: Henderson-Patterson bodies (eosinophilic intracytoplasmic inclusion that push the nucleus aside)
Definition
molluscum contagiosum
Term
honey-colored crust
Definition
bullous impetigo
Term
histology: subcorneal blister with neutrophils and bacteria (gram pos cocci in clusters)
Definition
bullous impetigo
Term
onchomycosis
Definition
dermatophytes
Term
KOH prep, PAS tissue stain
Definition
dermatophytes
Term
'spaghetti and meatballs' appearance in stratum corneum
Definition
tinea versicolor
Term
macules and patches of hypo/hyperpigmentation on trunk.
Definition
tinea versicolor
Term
poor hygiene, overcrowding, common between the digits
Definition
scabies
Term
Hutchinson's sign
Definition
A skin lesion on the tip of the nose precedes the development of ophthalmic herpes zoster (HZV)
Term
3M's - Multinucleated keratinocytes, Molding of nuclei, Marginated chromatin -- seen on Tzanck smear
Definition
HSV1/HSV2
Term
palpable purpura
Definition
polyarteritis nodosum (vasculitis)
Term
non-palpable purpura
Definition
vasculopathy
Term
bilateral palpable purpura on ant legs
Definition
polyarteritis nodosum
Term
histology: inflammation of arteries in the subcutis with fibrin deposition
Definition
polyarteritis nodosum
Term
non-antibody mediated vesiculo-bullous dermatitis
Definition
epidermolysis bullosa
Term
Type III Hypersensitivity (immune complexes), small purpuric papules,
predominantly lower legs
Definition
LCV - leukocytoclastic vasculitis
Term
subtype of LCV characterized by predominant IgA-mediated vessel injury
Definition
HSP
Term
malar rash that spares nasolabial folds, non-scarring, associated with SLE
Definition
acute cutaneous lupus
Term
violaceous plaques with central scarring esp on head, neck and ears (conchal bowls), low assoc with SLE
Definition
discoid lupus
Term
CREST
Definition
Signs of limited cutaneous scleroderma.
Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, Telangiectasias
Term
term for localized scleroderma
Definition
morphea
Term
white atrophic plaques associated with localized scleroderma at sites of trauma
Definition
lichen sclerosis
Term
epidermal atrophy (more than SLE)
Definition
dermatomyositis
Term
pretibial yellow-pink plaques with violaceous border that may ulcerate when injured. associated with diabetes
Definition
necrobiosis lipoidica
Term
target lesions that look like pineapple slices; pathergy
Definition
Sweet's syndrome
Term
Acute Febrile Neutrophilic Dermatosis
Definition
Sweet's syndrome
Term
histology: PMN infiltrate without vasculitis
Definition
Term
Inflammatory ulcer with rolled violaceous border; pathergy; associated with inflammatory bowel disease, connective tissue disease, and hematologic disorders
Definition
pyoderma gangrenosum
Term
lesion with koebnerization - central keratinaceous plugs with central sparing on back
Definition
acquired perforating dermatosis
-assoc with ESRD
Term
aka Kyrle's Disease
Definition
acquired perforating dermatosis
-assoc with ESRD
Term
retiform purpura on fatty areas, central black eschar
Definition
calciphylaxis
-assoc with ESRD
Term
histology: calcium in vessels
Definition
calciphylaxis
-assoc with ESRD
Term
calf pump muscle insufficiency
Definition
stasis dermatitis
Term
erythema migrans
Definition
Lyme Disease
Term
erythema infectiosum -- slapped cheek appearance
Definition
parvovirus B19
Term
viral infection during pregnancy that may cause anemia, fetal hydrops or death
Definition
parvovirus B19
Term
widespread rash usually occurring in children as a result of a 'bug or drug'
Definition
viral exanthem
Term
Rapidly growing red friable papule or polyp composed of a fibromyxoid matrix
Definition
pyogenic granuloma
Term
hand-foot-mouth-butt disease
Definition
coxsackie virus
Term
maculopapular rash occurring 7-10 days after initiation of a drug, okay to continue treatment
Definition
morbilliform/exanthematous drug eruption
Term
morbilliform rash occurring 2-6 weeks after initiation of a drug, with fever, hematologic abnormalities and visceral involvement. Must discontinue drug.
Definition
DRESS Syndrome
Drug-Reaction (Rash) Eosinophilia Systemic Symptoms
Term
dusky cutaneous eruption that recurs at the same site with each exposure to a particular medication.
Definition
fixed drug reaction
Term
dusky macules on the trunk or face +/- epidermal detachment
Definition
Stevens-Johnson Syndrome
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