Term
| Which class of antidepressant has cardiac AEs? |
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Definition
TCA
- for pts over 40, an ECG warranted before initiation
- use SSRI or bupropion if heart issues (ventricular arrhythmia, subclinical sinus node dysfcn, conduction defects, prolonged QT interval, recent MI) |
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Term
|
Definition
| amitriptyline, clomipramine, imipramine, doxepin |
|
|
Term
| List secondary amine TCAs |
|
Definition
| desipramine (imipramine derivative), nortriptyline (amitryptiline derivative) |
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|
Term
| Compare/contrast secondary and tertiary amine TCA properties |
|
Definition
tertiary amines - 5HT and NE effects
secondary amines - NE > 5HT effects, less dry mouth, dizziness, weight gain |
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Term
| Which TCA has the least anticholinergic side effects? |
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Definition
|
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Term
| Which TCA has the least hypotensive effects? |
|
Definition
|
|
Term
| List symptoms of serotonin syndrome |
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Definition
| excitement, anxiety, rigidity, tremor, clonus, increased temp/HR/BP, delirium, diaphoresis |
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Term
| List symptoms of discontinuation syndrome with abrupt d/c of some antidepressants, eg paroxetine, venlafaxine |
|
Definition
FINISH x 10 days
- flu
- insomnia
- nausea
- imbalance
- sensory disturbance
- hyperactivity |
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