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Dental Pharm Final
Dental Student Pharmacology
19
Pharmacology
Professional
04/19/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
Theraputic use at Adrenogenic Receptors (Agonists)
Bronchodilation in emerg:
ADHD:
HTN inverse agonist:
Bronchodilation:
Definition
Epinephrine
Ritalin and Adderall
Clonidine (Catapres)
Albuterol (Proventil)
Term
Epinephrine
Indications:
MOA:
Use in dent:
Cautions:
Drug interactions:
Definition
I:Local vasoconstriction
Hypotension and shock
Bronchodilation
Allergy
M: Direct alpha/beta adrenergic stim
UiD: Vasoconstriction
C: Card,CVD,DM,Parkinsons,Thyroid
(0.04mg TOTAL with card pts)
DI: TCA,Beta blockers
(-olol,-ilol,-alol)
Term
Provigil(Modafinil)
Indications:
MOA:
Use in dent:
Cautions/Adv effect:
Drug interactions:
Definition
I: Narcolepsy, shift work disorder
M: alpha 1 agonist, inhib dope reup
UiD: n/a
C/AE:mania, delusions, hallucinations, suicidal ideation, aggression, persistent sleppiness
Term
Clonidine (Catapres)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I: HTN
C/M:Presynaptic alpha 2 agonist, inhib symp outflow (NE) to body and inhib bv receptors in body
UiD:N/A
C/A: dry mouth, Ortho Hypotn
Term
Proventil (Albuterol)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I:Asthma, COPD
C/M: Beta 2 sympathetic agonist, stim beta 2 recept in lungs causing bronchodilation
UiD: N/A
C/A:unusual taste, drying/irritation of oropharynx
DI: N/A
C/A
Term
Terazosin (Hytrin)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I:HTN, BPH
C/M: alpha symp antagonist, blocks alpha 1 receptor leading to sm relax
UiD:N/A
C/A: dry mouth, dizziness, ortho hypotn
DI:
Term
Tamsulosin (Flomax)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I: BPH
C/M: alpha symp antagonist, blocks alpha 1A and alpha 1D adrenergic recept subtype found only in prostate
UiD:N/A
C/AE:
DI:
Term
Metoprolol (Toprolol XL)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I:HTN
C/M:selective beta 1 blocker, competitive inhib of NE/Epi at beta 1
UiD:N/A
C/AE:Altered taste, lichenoid rxns, ortho hypotn
DI:
Term
Propranolol (Ineral)
Indications:
Class/MOA:
Use in dent:
Cautions/Adverse effects:
Drug interactions:
Definition
I: CD, Stage fright, tremor, migraine
C/M:nonselective beta blocker, competitive inhib of beta recept
C/AE: may enhance pressor response to epi, HTN and bradycardia
Term
Carvedilol (Coreg)
Definition
I: CHF
C/M: beta 1 and alpha 1 antagonist
PCOL: decrease HR/contractility, decrease, BP through alpha blockade
Term
2 mechanisms of cholinergic drugs
Definition
1. Reversible cholinesterase inhib--> prolong t1/2 of Ach at recept site
2. Direct acting--> bind to and stimulate muscarinic recept
Term
Tacrine(Cognex)
Definition
I: Alzheimer's, Parkinson's w/dementia
C/M: parasymp agonist, prolong Ach t1/2 in brain
Term
Pilocarpine(Salagen)
Cevimeline(Evoxac)
Definition
I:salivary stimulants
M:Agonist at muscarinic receptors
C/AE: pts with COPD, parkinsons.
Term
3 Pts who are contraindicated for use of cholinergic drugs
Definition
asthma, CVD, and ulcer pts
Term
2 Drug interactions of antimuscarinic (parasymp antagonists) drugs
Definition
1. anticholinergic effects potentiated by antihistamine
2. CYP2D6 inhib: may diminish therapeutic effect of Codeine (Enablex)
Term
3 Therapeutic uses for drugs at nicotinic receptors
Definition
1. smoking cessation programs, gum, patches
2. Neuromuscular jnxn blockers used in surgery/intubation-->succinylcholine
3. Botulinum toxin type A--> botox
Term
Nicotine
Definition
C/M: binds to alpha4beta2 nicotinic Ach recept, stim CNS mesolimbic dopamine system
Term
Varenicline (Chantix)
Definition
C/M: binds to alpha4beta2 nicotinic Ach recept, producing agonistic activity while simultaneously blocking nicotine binding at alpha4beta2 recept.
C/AE: nightmares, psycosis
Term
Botulinum Toxin
Definition
C/M:prevents synaptic vesicle fusion with membrane
I: focal dystonias, headache, and pain syndromes
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