Term
Theraputic use at Adrenogenic Receptors (Agonists) Bronchodilation in emerg: ADHD: HTN inverse agonist: Bronchodilation: |
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Definition
Epinephrine Ritalin and Adderall Clonidine (Catapres) Albuterol (Proventil) |
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Term
Epinephrine Indications: MOA: Use in dent: Cautions: Drug interactions: |
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Definition
I:Local vasoconstriction Hypotension and shock Bronchodilation Allergy M: Direct alpha/beta adrenergic stim UiD: Vasoconstriction C: Card,CVD,DM,Parkinsons,Thyroid (0.04mg TOTAL with card pts) DI: TCA,Beta blockers (-olol,-ilol,-alol) |
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Term
Provigil(Modafinil) Indications: MOA: Use in dent: Cautions/Adv effect: Drug interactions: |
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Definition
I: Narcolepsy, shift work disorder M: alpha 1 agonist, inhib dope reup UiD: n/a C/AE:mania, delusions, hallucinations, suicidal ideation, aggression, persistent sleppiness |
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Term
Clonidine (Catapres) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I: HTN C/M:Presynaptic alpha 2 agonist, inhib symp outflow (NE) to body and inhib bv receptors in body UiD:N/A C/A: dry mouth, Ortho Hypotn |
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Term
Proventil (Albuterol) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I:Asthma, COPD C/M: Beta 2 sympathetic agonist, stim beta 2 recept in lungs causing bronchodilation UiD: N/A C/A:unusual taste, drying/irritation of oropharynx DI: N/A C/A |
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Term
Terazosin (Hytrin) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I:HTN, BPH C/M: alpha symp antagonist, blocks alpha 1 receptor leading to sm relax UiD:N/A C/A: dry mouth, dizziness, ortho hypotn DI: |
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Term
Tamsulosin (Flomax) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I: BPH C/M: alpha symp antagonist, blocks alpha 1A and alpha 1D adrenergic recept subtype found only in prostate UiD:N/A C/AE: DI: |
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Term
Metoprolol (Toprolol XL) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I:HTN C/M:selective beta 1 blocker, competitive inhib of NE/Epi at beta 1 UiD:N/A C/AE:Altered taste, lichenoid rxns, ortho hypotn DI: |
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Term
Propranolol (Ineral) Indications: Class/MOA: Use in dent: Cautions/Adverse effects: Drug interactions: |
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Definition
I: CD, Stage fright, tremor, migraine C/M:nonselective beta blocker, competitive inhib of beta recept C/AE: may enhance pressor response to epi, HTN and bradycardia |
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Term
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Definition
I: CHF C/M: beta 1 and alpha 1 antagonist PCOL: decrease HR/contractility, decrease, BP through alpha blockade |
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Term
2 mechanisms of cholinergic drugs |
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Definition
1. Reversible cholinesterase inhib--> prolong t1/2 of Ach at recept site 2. Direct acting--> bind to and stimulate muscarinic recept |
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Term
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Definition
I: Alzheimer's, Parkinson's w/dementia C/M: parasymp agonist, prolong Ach t1/2 in brain |
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Term
Pilocarpine(Salagen) Cevimeline(Evoxac) |
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Definition
I:salivary stimulants M:Agonist at muscarinic receptors C/AE: pts with COPD, parkinsons. |
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Term
3 Pts who are contraindicated for use of cholinergic drugs |
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Definition
asthma, CVD, and ulcer pts |
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Term
2 Drug interactions of antimuscarinic (parasymp antagonists) drugs |
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Definition
1. anticholinergic effects potentiated by antihistamine 2. CYP2D6 inhib: may diminish therapeutic effect of Codeine (Enablex) |
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Term
3 Therapeutic uses for drugs at nicotinic receptors |
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Definition
1. smoking cessation programs, gum, patches 2. Neuromuscular jnxn blockers used in surgery/intubation-->succinylcholine 3. Botulinum toxin type A--> botox |
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Term
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Definition
C/M: binds to alpha4beta2 nicotinic Ach recept, stim CNS mesolimbic dopamine system |
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Term
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Definition
C/M: binds to alpha4beta2 nicotinic Ach recept, producing agonistic activity while simultaneously blocking nicotine binding at alpha4beta2 recept. C/AE: nightmares, psycosis |
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Term
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Definition
C/M:prevents synaptic vesicle fusion with membrane I: focal dystonias, headache, and pain syndromes |
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