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Dental Histology - Eye
Exam 3
39
Medical
Professional
11/05/2008

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Term
The EYE
Definition
-photosensitive
-partially surrounded by the orbits
-derived from:
        surface ectoderm
        outpocketing of prosencephalon
 
Term

Anatomical Components of the EYE

 

(4) 

Definition
1. Globe
        -provides support for other parts of the eye
2. Lens
        -image focus
3. Photosensitive Cells
        -receive visual stimuli
4. Neurons
        -transmit visual information to the brain
 
Term

Structural Layers of the EYE

 

(3) 

Definition
1. Outer Layer (tunica fibrosa)
        -cornea and sclera
2. Middle Layer (vascular)
        -choroid, ciliary body, and iris (uveal tract)
3. Inner Layer
        -retina
 
Term

Compartments in the EYE

 

(3) 

Definition
1. Anterior Chamber
        -between cornea, and iris and lens
        -filled with aqueous humor
2. Posterior Chamber
        -between iris, ciliary body, zonule, and lens
        -filled with aqueous humor
3. Vitreous Space
        -bounded by the lens and retina
        -filled withgelatinous vitreous body
            -maintains shape of eye
            -protects retina from trauma of rapid move
Term

Tunica Fibrosa - Outer Layer

 

(2 components) 

Definition
1. Sclera = "whites of the eyes"
 
2. Cornes = anterior, transparent part of the globe 
Term
Sclera = "whites of the eyes"
 
 
Definition
-dense fiberous connective tissue
-many multidirectional collagen bundles parallel to             surface of eye 
 
-outer surface of sclera = episclera
        -loose connective tissue
 
Term
Cornea = anterior, transparent part of the globe
Definition
-multilayered
-avascular
-outer non-keratinized stratified squamous epitheliu
    -high degree of mitotic activity
    -richly innervated
-vascular supply along periphery
    -nutrients diffuse through these vessels 
    -merge into Schlemm's canal
           -drains anterior chamber
           -empties into regional venous system
 
Term

Vascular - Middle Layer

 

(3 structures) 

Definition
-structures comprise the uveal tract
 
1. Choroid
2. Ciliary Body
3. Iris 
Term
Choroid
Definition
-deeply pigmented (numerous melanocytes)
-many blood vessels
-loose connective tissue
    -abundent collagen and elastic fibers
    -leukocytes
           ->lympocytes, mast cells, macrophages, and                 plasma cells
-choriocapillary layer
    -vascularized
    -responsible for nutrition of retina
    -compromise this = retina damage 
Term
Ciliary Body
Definition
-key for image focusing
-widening of choroid adjacent to lens
-appears triangular in shape in cross-section
-loose connective tissue than encases ciliary muscle
 
--> ciliary muscle
--> ciliary processes 
Term
Ciliary Muscle
Definition
-smooth muscle fibers
-insert on both sclera + multiple point on ciliary body 
-allow for:
    -stretching of choroid
    -releasing tension on lens
    = proper visual accommodation (image focusing) 
Term
Ciliary Processes
Definition
-envaginations of ciliary body
-loose connective tissue core
-covering of simple columnar epithelium
-Oxytalan (zonule) fibers emerge
    -insert on lens capsule (hold it in place)
 
Constituent cells of ciliary processes are responsible for secretion of aqueous humor 
Term
Iris
Definition
-projection of choroid
-partially covers the lens
-leaves and aperture 
        -known as pupil
 
Term
Structure of the Iris
Definition
-rough anterior surface
    -covers poorly vascularized connective tissue
    -contains melanocytes
 
-below = connective tissue (highly vascularized)
 
-smooth posterior surface
    -covered by 2 layers of epithilium
        inner layer = melanocytes + pigmented
        outer layer = cellular myofilaments that make                             up dilator pupillae muscle
Term

Iris Regulates Amount of Light Entering

 

(adaptation) 

Definition
-regulated by melanocytes and dilator pupillae muscle
 
-sphincter pupillae muscle = concentric bundles of                         smooth muscle surrounding the pupil
                            (regulates light inflow)
 
-dilator pupillae muscle = processes sympathetic                                                 innervation
-sphincter pupillae muscle = processes                                                         parasympathetic innervation
Term

Lens

 

(3 Parts) 

Definition
-oviod, highly elastic structure
 
1. Lens capsule
2. Subcapsular epithelium
        -simple cuboidal or columnar only found on                     anterior surface
3. Lens Fibers
        -below the epithelium
        -elongated subcapsular epithelial cells 
             -no organelles = transparent and filled with                             crystallins (proteins)
Term

Retina - Inner Layer

 

(2 layers) 

Definition
-photosensitive elements in posterior portion
-2 distinct layers
    1. Pigment Epithelium
    2. Neural (optical) Retina 
 
The retina posterior to the ora serrata is sensitive to light and transmits this information to the brain via th eoptic nerve. 
Term
Retina - Pigment Epithelium
Definition
-single layer of columnar cells
-process and transport vit A to photoreceptor cells 
-produce melanin
-absorb light after stimulation of the photoreceptors 
Term

Retina - Neural Optical Retina

 

(5 Layers) 

Definition
-detects light
-composed of many types of neurons and synapses
 
1. outer layer of rods and cones
2. external plexiform layer
3. bipolar neurons
4. internal plexiform layer
5. ganglion cells
Term

Retina - Neural Optical Retina

 

Outer Layer of Rods and Cones 

Definition
Several Functional Regions:
 
-single dendrite that's sensitive to light
        -component of outer segment
-inner and outer segments
-nuclear region
-synaptic region
 
Term

Retina - Neural Optical Retina

 

External Plexiform Layer 

Definition
Contains: 
 
-synapses between rods and cones
 
-bipolar neurons 
Term

Retina - Neural Optical Retina

 

Bipolar Neurons 

Definition
-integrate rods and cones with ganglion cells
Term

Retina - Neural Optical Retina

 

Internal Plexiform Layer 

Definition
Contains:
 
-synapses between bupolar cells and ganglion cells 
Term

Retina - Neural Optical Retina

 

Ganglion Cells 

Definition
-transmit visual info to brain via their collective axons
 
-collective axons become optic nerve
 
 
***Light first passes through ganglion cells (they are closest to vitreous body), then bipolar neurons, before it hits rods and cones.***
 
Gangion Cells --> Bipolar Neurons --> Rods + Cones 
Term

Cells of the Retina

 

(8) 

Definition
1. rods
2. cones
3. diffuse bipolar cells
4. monosynaptic bipolar cells
5. ganglion cells
6. horizontal cells
7. amacrine cells
8. supporting cells 
Term

Cells of the Retina

 

Rods 

Definition
-highly photosensitive
-resposive to LOW LIGHT conditions
-elongated outer segment = light sensitive part
    -contains many stacked membranous disks
 
    Disks contain:
        Rhodopsin - interaction with light is 1st step in                             vision
Term

Cells of the Retina

 

Cones 

Definition
-elongated conical processes =
        responsive to COLOR and
                            HIGER INTENSITY LIGHT
-less than 5% of photoreceptos
-membraneous disks (in outer segement) formed by         invaginations of cell membrane
 
-visual pigment = IODOPSIN = sensitive to RGB light
 
-provide better visual perception than rods 
Term

Cells of the Retina

 

Diffuse Bipolar Cells 

Definition

synapse with 2+ photreceptors

 

(multiple rods and cones) 

Term

Cells of the Retina

 

Monosynaptic Bipolar Cells

Definition

synapse with 1 photoreceptor

 

(1 rod or cone) 

Term

Cells of the Retina

 

Ganglion Cells

Definition

neurons whose axons converge to form the optic nerve

 

may be diffuse or monsynaptic 

Term

Cells of the Retina

 

Horizontal Cells 

Definition

connect photoreceptors to one another

 

 

communication b/w rods and cones 

Term

Cells of the Retina

 

Amacrine Cells 

Definition
connect ganglion cells to one another
Term

Cells of the Retina

 

Supporting Cells 

Definition

Consist of:

-microglia

-astrocytes

-large, branching Muller cells 

  

Term

Accessory Structure of the Eye

 

(3) 

Definition
1. Conjunctiva
2. Eyelids
3. Lacrimal Glands 
Term
Conjunctiva
Definition
-mucous membrane
-covers cornea and inner surface of the eyelid
-stratified columnar epithelium
-goblet cells 
Term

Eyelids

 

(3 glands) 

Definition
-protective fold of skin
-Contains 3 types of Glands 
    1. Meibomian Gland
           -sebaceous gland
           -does NOT empty into hair follicle
           -produces lipid-rich surface over tear film
                  -prevents evaporation
   2. Glands of Zeis
           -sebaceous glan
           -empty into eyelash follicle
   3. Glands of Moll
           -modifies sweat gland
           -empty into eyelash follicle
Term
Lacrimal Glands
Definition
-secrete tears
        -serous lubricating fluid rich in lysozyme
-compund tubuloacinar gland
      -resembles parotid tissue
Term
Fovea
Definition
-adjacent to optic nerve
-highest visual acuity
-structurally different from retina
-only external plexiform layer
 
Term
Blind Spot
Definition
no retina in front of optic nerve
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