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Dental Histology - Circulatory
Exam 2
39
Medical
Professional
10/04/2008

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Term
Circulatory System Composed of...
Definition

Blood Vascular System

and

Lymphatic Vascular System 

Term
Lymphatic Vascular System composed of...
Definition
lymphatic capillaries that eventually anastomose and empty near the heart
Term
Blood Vascular System Composed of...
Definition
1. heart - pumps the blood
2. arteries - transmots blood to the tissues through a     network of tubules of decreasing calibre
3. capillaries - a series of interconnected tubules that     arobize among the tissues and allow for gas              exchange, connect small arteries and veins
4. veins - a series of anastomosing tubules of             increasing calibre that transmit blood and                 metabolic products back tot he heart 
Term

High pressure blood vessels

 

 

Definition

thick walled

 

ex. systemic arteries 

Term
Low pressure blood vessels
Definition

thin walled

 

ex. pulmonary arteries 

Term
Tunics - 3 types
Definition

represent the layers of the blood vessels

 

1. tunica intima

2. tunica media

3. tunica adventitia 

Term
Tunica Intima
Definition
-inner most
-simple squamous epithileum (on basal lamina)
-subendothelial layer (thin layer of loose connective     tissue; may have smooth muscle running                 longitudenally)  
-in arteries elastin (internal elastic lamina) is                the inner border of this layer 
Term
Tunica Media
Definition
-middle layer
-smooth muscle running in tight concentric layers 
-elastic & reticular fibers and proteoglycans                 interspersed in smooth muscle
-type III collegen
-in arteries, outer border is external elastic lamina         (thinner than internal elastic lamina) 
Term
Tunica Adventitia
Definition
-type I collegen
-elastic fibers
-longitudinal arrangment
-continuous with connective tissue surrounding the         organ that the vessel serves 
Term

Vasa Vasorum

 

"vessels of the vessels" 

Definition
-within adventitia and outer media
-provides nourishment to outer part of thick vessels 
    (O2 diffusion is primary nourishment still)
-arises either from artery it is supplying or nearby         arteries 
-more common in veins since that blood is                     deoxygenated (less O2 nuorishment)
 
Term
Innervation
Definition
mural smooth muscle innervated by branches of unmylenated sympatentic neurons (vasomotor nerves)
 
located in tunica adventitia in arteries
located in tunica adventitia and media in veins
 
releases norepinephrine in smooth muscle
    (causes smooth muscle to contract --> decreases     size of vessel lumen)
releases acetylcholine and norepinephrine in skeletal     muscel (causes smooth muscle to relax)
Term
Structure of Blood Vessels
Definition

1. Capillaries

2. Arteries

3. Veins 

Term
Capillaries
Definition
-conduits for gas and metabolite exchange b/w tissue         and blood
-single layer of endothelial cells
    -->flattened, elongated and slightly tappered
    -->nuclei slightly protruding into capillary lumen 
    -->contain zonula occludens and gap junctions
-pericytes
    -->pluripotential cells with elongated processes
    -->surround endothelial cells and small venules
    -->work in wound repair
    -->may have a contractile function 
Term
3 types of capillaries
Definition

1. continuous (somatic)

2. fenestrated (visceral)

3. discontinuous 

Term

Continuous (somatic) Capillaries

Definition
-no fenestrations in wall
-continuous basal lamina
-transport in both directions via pinocytic vesicles
    exception: majority of nervous systemm helpin         establish blood-brain barrier 
-found in tissues require rapid gas exchange
    --> muscle, connective tissue, exocrine glands,                 nervous tissue, bone, lung 
 
Term
Fenestrated (visceral) Capillaries
Definition
-fenestrations sometimes covered by thin diaphragm
-continuous basal lamina
-found in tissues requiring substantial fluid exchange
    -->kidney, intestine, endcrine glands
 
-->in glomerulus of kidney; no diaphrams  
Term
Discontinuous Capillaries
Definition
-serpentigenous and wide
    -->result in slowing of blood flow
-large fenestrations (no diaphragms)
-discontinuous basal lamina
    -->allows for movement of large substanses and/or         cells
-found in liver and hematopoietic organs
                            (spleen, bone marrow) 
Term
Functions of Capillaries
Definition
1. Selective Permeability Barrier (varies)
2. Metabolism (can synthesize and break down stuff)
    -->activation - conversion on inactive to active
    -->inactivation - conversion of active to inert
    -->lipoysis - breaks down lipoproteins to make                             triglycerides and cholesterol 
    -->synthesis of vasoactive factors - vascular tone
3. Antithrombogenesis (prevents contact b/w                 platelets and thrombogenic subendothelial                 connective tissure 
Term
Arteries
Definition
-transport blood to body tissues
-different function according to location
 
Proximal - resist changes in blood pressure
Distal - regulate blood flow to terminal segments 
Term
Conducting Arteries
Definition
-large
-transport blood away form heart
-dampen pressure changes resluting from a beating             heart 
Term
Distributing Arteries
Definition
-medium size
-supply blood to organs, muscle, etc.
-regulate amount of blood by contraction of their             smooth muscle coat 
Term
Arterioles (less then 0.5 mm in diameter)
Definition
-narrow lumina
-lined by endothelium
-thin subendothelial layer
-internal elastic lamina in large arteriols only
-thin media (one or two smooth muscle layers)
-NO external elastic lamina
-thin adventitia 
Term
Metarterioles
Definition
-link arterioles with capillaries
-surrounded by discontinuous smooth muscle coat
-helps regulate blood flow into capillary
-maintains pressure gradient b/w arterial and venous      system
-sphincter (ring of smooth muscle) can stop flow into     capillary at the junction 
Term
Musclar Arteries
Definition
-majority of arteries in body
-subendothelial layer thicker than in arteriols
-prominent internal elastic lamina
-thickness of media increased
-in larger arteries, there is an external elastic lamina 
Term
Elastic Arteries
Definition
-large arteries
0aorta and its largest branched
-conducting arteries (convey blood to distributing)
-thick intima
-internal elastic lamina (normal thickness)
-media composed of concentric elastic laminae 
    -->has smooth muscle and reticular fibers
    -->increases with age
-thin adventitia
-NO external elastic lamina 
Term
Veins
Definition
-thin walled vessels
-return blood to the heart
-assisted by smooth muscle and valves
-more than 70% of blood volume is in the venous             system at a given moment 
Term
Venules (type of vein)
Definition
-very thin
-endothelium surrounded by rare smooth muscle,             pericytes, outer adventitia 
-smaller ones resembe capillaries in strucute and             processes but have greater diameter 
Term
Small and Medium Sized Veins
Definition
-endothelium (may be surrounded by thin intima)
-thin media containing smooth muscle, elastc, and             reticular fibers, and thick adventitia 
-internal valves (extensions of intima)
        most commonly found in limbs
-valves function with contraction of adjacent skeletal         muscle 
        -->ensures one-way flow of blood
 
Term
Large Veins
Definition
-well developed intima
-thick media and adventitia
-in large abdominal veins and large veins inferior to     heart:
    -->longitudinal smooth muscle within adventitia  
        -reinforces vein
         -help propel blood back to the heart
Term
Heart
Definition
-drives blood throughout the body
-composed of cardiac muscle and fiberous skeleton
 
Term
Tunics of the Heart (3)
Definition
1. Endocardium
2. Myocardium
3. Epicardium 
   
Term
Endocardium
Definition
-like tunica intima
-contains: 
    endothelial cells on bed of collegen
    elastic fibers
    smooth muscle fibers
-subjacent to subendocardial layer which contains:
    -veins
    -nerves
    -Purkenje cell branches 
Term
Myocardium
Definition
-thickes tunic
-contains:
    cardiac muscle fibers
        (spiral arrangement around heart chambera)
Term
Epicardium
Definition
-layer of esothelial cells
    (simple squamous epithelium)
-subepicardial loose connective tissue contains:
    -veins
    -nerves
    -nerve ganglia 
Term
Heart Valves
Definition
-core = dense fiberous connective tissue
-linning = endothilium
-attached to the fiberous skeleton at annuli fibrosi 
Term
Heartbeat
Definition
SAN (pacemaker) - modified cardiac muscle cells
     - right atrium near opening of superior vena cave
     -most rapid activity
AVN - attached to SAN by branches of conducting cells
     -cardiac muscle cells lie beneath endocardium in         right atrium near septum leads to...
AV Bundle of His - comprised of Purkinje cells
     - enter fiberous skeleton and branch, descend to         heart apex and turn back
     -contact cardiac muscle via gap junctions
     -contraction begins at the apex 
Term
Lymphatic Vascular System
Definition
-thin walled endothelium lined vessels
    (Lymphatic Capillaries) 
    -no fenestratio
    -no zonula occldens
    -incomplete basal lamina
    -contain valves
    -larger ones resembe veins 
-collect lymph and transmit it back to blood
-FLOW IS ALWAYS TOWARDS THE HEART
 
Term
Carotid Body
Definition
-near bifurcation of common carotid arteries
-chemoreceptor
-sensitive to:
    low O2 tension
    high bicarbonat concentration
    low arterial blood pH 
Term
Carotid Sinus
Definition
-dilation of internal carotid artery
-senses changes in blood pressure 
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