Term
| What are the steps in neurogenesis? |
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Definition
Neurogenic development
- Determination of neurogenic region
- Selectior of neural precursors
Neuronal development
- Pathway selection
- Target selection
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Term
| Explain the determination of the neurogenic region. |
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Definition
Edges of neural plate raise above surface and forms 2 parallel folds with a depression (the neural groove).
These come together over the dorsal midline and a tube separates it from adjacent ectoderm. |
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Term
| Explain the selection of neural precursors. |
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Definition
| Neuroblasts in ventral pole move inwards. Form 3 longditudinal collumns each side of ventral midline. They divide into proneural clusters and these produce signals to promote their own development. This prevents adjacent cells from following it's fate. |
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Term
| Explain pathway selection. |
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Definition
| Axons spout from immature neurons and elongate through tissues to reach synaptic partners in other areas of the body, guided by the growth cone. |
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Term
| Explain target selection. |
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Definition
| These can have long-range cues (chemoattraction and chemorepulsion) or short range cues (contact attraction and repulsion). |
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