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oxidative breakdown of glucose; two stages are glycolysis and respiration |
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– breakdown of 1 glucose => 2 pyruvate in CYTOplasm • Glucose => 2Pyruvate + 2ATP + 2NADH + 2H +2H20 • Phosphofructokinase (step 3) – rate determining step; ATP consumed • Step 4 where fructose splits into 2 PGAL molecules |
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anaerobic conditions; NAD+ must be regenerated; produces only 2ATP per glucose |
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– can yield 36-38 ATP; O2 is final acceptor // PDC, CAC, ETC • PDC – mito MATRIX; CO2 is lost; NAD+ reduced to NADH • Citric Acid Cycle – Krebs cycle 2Acetyl-CoA => 4CO2 + 6NADH + 2FADH2 + 2GTP + 4H +2CoA • ETC – also called OXIDATIVE phosphorylation INNER mito MEMbrane; electrons transferred from NADH and FADH2 to oxygen; cytochromes are the carrier molecules with Fe in functional unit |
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Eukaryotic ATP production / glucose |
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glycolysis (6 ATP) 2ATP invested -2 ATP 4ATP generated +4 ATP 2NADH X 2 +4 ATP *PDC (6 ATP) 2NADH X 3 +6 ATP *CAC (24 ATP) 6NADH X 3 +18 ATP 2FADH2 X 2 +4 ATP 2GTP X 1 +2 ATP _________ TOTAL +36 ATP |
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When glucose runs low, body utilizes the following in order: other carbs (glycogen in liver), fats, proteins (only when carbs and fats gone) |
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Fats are stored in adipose tissue as triglyceride / hydrolyzed by lipases to fatty acids / carried by blood to tissues/ must be activated / GREATEST ATP yield / synthesized in cytosol / B-oxidation in mitochondrial matrix |
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converts lactate back to glucose |
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occurs in plants & bacteria. |
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where gas exchange between the circulatory system and the lungs occurs; surfactant reduces the surface tension |
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– diaphragm contracts/ flattens; increase in volume / decrease in pressure in lungs • nasal cavity → trachea → bronchus → bronchiole → alveoli |
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– passive process; decrease in volume/ increase in air pressure; diagphram expands |
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hemoglobin unloads O2 under conditions of low pH (high CO2 & [H+]) *Oxygen diffuses from alveolar air into blood |
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