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D&D Midterm - Pharm
Drugs Drugs Drugs
46
Pharmacology
Graduate
03/31/2011

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Cards

Term
Diphenhydramine (Benadryl)
Definition
1st Generation H1 Antihistamine
Term
Cetirizine (Zyrtec)
Definition
2nd Generation H1 Antihistamines
LESS Sedative/Anti-emetic
Term
Loratadine (Claritin)
Definition
2nd Generation H1 Antihistamines
LESS Sedative/Anti-emetic
Term
Fexofenadine (Allegra)
Definition
2nd Generation H1 Antihistamines
LESS Sedative/Anti-emetic
Term
Cimetidine (Tagamet)
Definition
H2 Antihistamine
INTERFERES with CYP450
Used to decrease acid production
Treat Peptic Ulcers/GERD/etc.
Treat GERD, etc.
Term
Ranitidine (Zantac)
Definition
H2 Antihistamine
Used to decrease acid production
Treat Peptic Ulcers/GERD/etc.
Term
Famotidine (Pepcid)
Definition
H2 Antihistamine
Used to decrease acid production
Treat Peptic Ulcers/GERD/etc.
Term
Nizatidine (Tazac/Axid)
Definition
H2 Antihistamine
Used to decrease acid production
Treat Peptic Ulcers/GERD/etc.
Term
Etanercept (Enbrel)
Definition
Recombinant fusion protein - binds TNFR
Subcutaneous injection
Term
Infliximab (Remicade)
Definition
Chimerical monoclonal Ab
Anti-TNFa
IV infusion
Term
Adalimumab (Humira)
Definition
Recombinant human monoclonal Ab
Anti-TNFa
Subcutaneous injection
Term
Anakinra (Kineret)
Definition
Endogenous protein
Recombinant IL-1R antagonist
Daily subcutaneous injection
Term
Abatacept (Orencia)
Definition
Fusion protein
CTLA4 linked to IgG
Inhibits costimulation
IV
Term
Certolizumab (Cimzia)
Definition
PEGylated Fab of humanized Anti-TNFa Subcutaneous injection Treat Crohn's
Term
Benlysta
Definition
New Lupus drug Monoclonal Ab to BAFF/BLyS
Term
Dinoprostone
Definition
PGE2
Induces Abortion
Term
Alprostadil
Definition
PGE1
Keeps open Ductus Arteriosus
Term
Epoprostenol
Definition
PGI2
Pulmonary Hypertension
Term
Misoprostol
Definition
PGE1
Prevents NSAID-induced ulcers
Term
Hydrocortisone (Cortisol)
Definition
SHORT Acting
Both GC & MC Activity
Term
Cortisone
Definition
SHORT Acting GC
Inactive Topically (Prodrug)
Term
Prednisone
Definition
INTERMEDIATE Acting GC
Inactive Topically (Prodrug)
Term
Prednisolone
Definition
INTERMEDIATE Acting GC
Term
Methylprednisolone
Definition
INTERMEDIATE Acting GC
NO MC Activity
Term
Triamcinolone
Definition
INTERMEDIATE Acting GC
NO MC Activity
Acetonide form is 100x more active topically
Term
Betamethasone
Definition
LONG Acting GC
NO MC Activity
Term
Dexamethasone
Definition
LONG Acting GC
NO MC Activity
Term
Antithymocyte Globulin
Definition
Induction Therapy
Rabbit/horse Antibodies to Human T Cells
Prevent Acute Rejection
Term
Muromonab
Definition
Induction Therapy
Anti-CD3
Term
Daclizumab
Definition
Induction Therapy
Anti-IL-2R
Term
Cyclosporine
Definition
Maintenance Therapy
Calcineurin Inhibitor
Prevents IL-2 transcription
Term
Tacrolimus
Definition
Maintenance Therapy
Calcineurin Inhibitor (100x more potent)
Prevents IL-2 transcription
Term
Sirolimus (Rapamycin)
Definition
Maintenance Therapy
mTOR Inhibitor
Inhibit Lymphocyte Growth/Metabolism
Term
Everolimus
Definition
Maintenance Therapy
mTOR Inhibitor
Inhibit Lymphocyte Growth/Metabolism
Term
Mycophenolate Mofetil
Definition
Cytotoxic Drug
Inhibits IMPD
Blocks de novo Purine Synthesis
Term
Azathioprine
Definition
Cytotoxic Drug
Metabolites inhibit de novo Purine Synthesis and DNA Synthesis
Term
Aspirin (ASA)
Definition
Irreversibly acetylates COX-1/2
Fully blocks COX-1
Partially blocks COX-2 (Anti-inflammatory 15-Epilipoxin formed)
Term
Mesalamine
Definition
NSAID
5-AminoSA
Treat IBS
Useful Topically
Term
Olsalazine
Definition
NSAID
5-AminoSA
Treat IBS
Term
Sulfasalazine
Definition
NSAID
5-AminoSA
Treat IBS
Term
Celecoxib (Celebrex)
Definition
NSAID
Selective COX-2 Inhibitor
Treat arthritis pain/inflammation
Term
Acetaminophen (Tylenol)
Definition
NSAID
NOT Anti-inflammatory
No adverse side effects
Term
Ibuprofen (Motrin/Advil)
Definition
NSAID
Propionic Acid Derivative
Term
Neproxen (Aleve)
Definition
NSAID
Propionic Acid Derivative
Longer half-life than Ibuprofen
Term
Methotrexate
Definition
DMARD
1st line of treatment
Folate Inhibition
Inhibit DNA/Purine Synthesis
Term
Leflunomide
Definition
DMARD
1st line of treatment
Inhibits Pyrimidine Synthesis
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