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Cytokines
Cytokines
21
Medical
Graduate
10/30/2010

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Cards

Term
IL-1
Definition
Similar to TNF-α; fever, leukocyte adhesion, lymphocyte co-stimulation
Term
IL-2
Definition
Growth factor for T, B, and NK cell proliferation
Term
IL-3
Definition
Proliferation of progenitor cells; growth factor for mast cells
Term
IL-4
Definition
Differentiation of Th2 cells and B cells; Ig class switching to IgE
Term
IL-5
Definition
Differentiation of B cells and eosinophils; Ig class switching to IgA
Term
IL-6
Definition
Hematopoiesis; acute phase response
Term
IL-7
Definition
Progenitor B and T cell growth
Term
IL-8
Definition
Chemotaxis of neutrophils
Term
IL-10
Definition
Inhibits the Th1 pathway
Term
IL-12
Definition
Co-activator of the Th1 pathway; induces IFN-γ production
Term
IL-13
Definition
Ig class switching to IgE
Term
IL-15
Definition
NK cell growth factor
Term
IL -17
Definition
Involved in many autoimmune disorders
Term
IL-18
Definition
Co-activator for IFN-γ production
Term
TGF-B
Definition
Anti-inflammatory; promotes wound healing; chemotaxis; Ig class switching to IgA
Term
TNF-a
Definition
Pro-inflammatory; neutrophil and endothelial cell activation; pro-apoptotic
Term
IFN-alpha, beta
Definition
Inhibits viral replication; primes macrophages
Term
IFN-gamma
Definition
Macrophage activation; inhibition of the Th2 pathway
Term
CSF-M
Definition
Colony simulating factor for cells of monocyte/macrophage lineage
Term
CSF-G
Definition
Colony simulating factor for cells of granulocyte lineage
Term
CSF-GM
Definition
Colony simulating factor for cells of myeloid lineage
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