Term
| Cytokines released by ALL T Cells |
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Definition
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Term
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Definition
| Promotes growth of T-Helper, T-Regs and cytotoxic T cells, stimulates NK cells |
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Term
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Definition
| Targets bone marrow progenitors, stem cells; supports growth & differentiation of bone marrow stem cells |
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Term
| Cytokines released by CD4+ Th1 cells |
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Definition
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Term
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Definition
| Activates macrophages (granuloma formation), promotes Ig class switching, stimulates NK cells to kill |
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Term
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Definition
| Targets PMN's & tumour cells (kills tumour cells, activates endothelium) |
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Term
| What type of pathogens do CD4+ Th1 cells target? |
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Definition
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Term
| Cytokines released by CD4+ Th2 cells |
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Definition
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Term
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Definition
| Induces T-Cells to differentiate to Th2, promotes B Cell growth, promotes class switching to IgE & IgG |
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Term
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Definition
| Promotes B cell growth & differentiation, promotes class switching to IgA, stimulates growth & differentiation of eosinophils |
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Term
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Definition
| Decreased expression of MHC Class 2 & Th1, inhibits activated macrophages & dendritic cells |
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Term
| Cytokines released by CD4+ Th17 cells |
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Definition
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Term
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Definition
| Targets epi/endothelium, neutrophils & fibroblasts to promote inflammation; recruits neutrophils |
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Term
| What type of pathogens do Th17 cells target? |
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Definition
| Fungi; promote inflammation |
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Term
| What type of pathogens do Th2 cells target? |
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Definition
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Term
| Cytokines released by CD4+ Treg cells |
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Definition
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Term
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Definition
| Stimulate B cell growth, inhibit Th1/Th17 response |
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Term
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Definition
| Suppress immune response, promote tolerance, promote wound healing |
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Term
| What cell type expresses TCR, CD3 & CD28? |
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Definition
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Term
| What is the funtion of TCR? |
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Definition
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Term
| What is the function of CD3? |
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Definition
| Associated with TCR (signal transduction) |
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Term
| What is the function of CD28? |
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Definition
| Binds B7 (aka B80) on APCs |
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Term
| What cell type expresses CD4, CD40L, CXCR4, CCR5? |
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Definition
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Term
| What cell type expresses CD8? |
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Definition
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Term
| What cell type expresses CD4, CD25? |
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Definition
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Term
| What cell type expresses Ig, CD19, CD20, CD21, CD40, MHC II, B7? |
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Definition
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Term
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Definition
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Term
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Definition
| Pro-B cells through to mature B cells |
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Term
| What is the function of CD21? |
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Definition
| Receptor for EBV, HHV-8; present on B cells & dendritic cells |
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Term
| What is the function of CD40? |
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Definition
| Co-stimulatory molecule on B cells, macrophages |
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Term
| What is the function of MHC II? |
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Definition
| Antigen presentation (found on B cells, macrophages) |
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Term
| What is the function of B7? |
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Definition
| Co-stimulatory molecule on B cells, macrophages; binds to CD28/CTLA4 on T cells |
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Term
| What cell type expresses CD14, CD40, CCR5, MHC II, B7, Fc Receptor, C3b receptor? |
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Definition
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Term
| What is the function of CD14? |
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Definition
| Pattern recognition receptor (PRR), recognises PAMPs (especially LPS) |
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Term
| What is the function of CCR5? |
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Definition
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Term
| What is the function of Fc Recptor? |
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Definition
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Term
| What is the function of C3b Receptor? |
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Definition
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Term
| What cell type expresses CD16, CD56? |
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Definition
| Natural Killer cells (NK cells) |
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Term
| What is the function of CD16? |
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Definition
| Binds Fc portion of IgG; mediates antibody-dependent cytotoxicity |
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Term
| What is the function of CD56? |
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Definition
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Term
| What cell type expresses CD34? |
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Definition
| Haematopoietic stem cells |
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Term
| Which cytokines induce fever & shock? |
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Definition
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Term
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Definition
| Macrophages, dendritic cells, monocytes |
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Term
| What is the main function of IL-1? |
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Definition
| Innate immune response, inflammation, fever |
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Term
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Definition
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Term
| What is the main function of IL-2? |
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Definition
| T-cell activation, proliferation and differentiation |
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Term
| What is the main function of IL-3? |
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Definition
| Haematopoeitic stem cell growth |
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Term
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Definition
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Term
| What is the main function of IL-4? |
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Definition
| B cell activation, IgE production |
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Term
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Definition
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Term
| What is the main function of IL-5? |
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Definition
| IgA production, eosinophil recruitment and activation |
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Term
| What is the main function of IL-6? |
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Definition
| Stimulates secretion of CRP, helps differentiate Thelper cells --> Th17 |
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Term
| What is the main function of IL-7? |
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Definition
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Term
| What is the main function of IL-8? |
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Definition
| Recruits inflammatory cells, neutrophil chemotaxis |
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