SOURCE: macrophages and Th1 cells

TARGETS/EFFECTS:

1. Endothelial cells (increased vascular permeability),

2. Neutrophils (activate microbial activity)

3. Hypothalamus (fever)

4. Liver (acute phase protein synthesis)

5. Muscles and fat (catabolism)

6. Other cells (apoptosis)

SOURCE: macrophages

TARGETS/EFFECTS:

1. Endothelial cells (activation)

2. Hypothalamus (fever)

3. Liver (synthesis of acute phase reaction proteins)

SOURCE: macrophages and dendritic cells;

TARGETS/EFFECTS:

1. Naive CD4 T cells (Th1 differentiation)

2. NK cells (increased cytolytic activity)

3. T cells (IFN-g synthesis)

SOURCE: IFN-a = macrophage, IFN-b = fibroblasts;

TARGETS/EFFECTS:

1. All cells (increase MHC class I, induce antiviral state)

2. NK cells (activation)

SOURCE: macrophages, endothelium, T cells

TARGETS/EFFECTS:

1. Liver (acute-phase proteins)

2. B cells (proliferation)

SOURCE: macrophages, activated Th2 cells

TARGETS/EFFECTS:

1. Macrophages (inhibit IL-12 production)

2. Dendritic cells (inhibit expression of costimulatory B7 and MHC II)

SOURCE: activated CD4 T cells

TARGETS/EFFECTS: Th1 and Th2 cells (proliferation)

SOURCE: activated Th2 cells

TARGETS/EFFECTS: Th1 cells (inhibits proliferation)

SOURCE: monocytes

TARGETS/EFFECTS:

1. Leukocytes (recruitment)

2. CD4 T cells (competes with HIV-1)

3. Naive CD4 T cell (promote Th1 cell immunity)

SOURCE: T cells

TARGETS/EFFECTS: T cells (activation during chronic inflammation)

SOURCE: monocytes and macrophages

TARGETS/EFFECTS:

1. Macrophages (activation)

2. Th2 cells (Th2 cell immunity)

SOURCE: Endothelium, monocytes, T cells

TARGETS/EFFECTS: eosinophils and basophils (recruitment during allergic reaction)

SOURCE: macrophages

TARGETS/EFFECTS:

1. Neutrophils (recruitment)

2. CD4+ and CD8+ T cells (mobilization)